BIOLOGICAL ACTIVE COMPONENTS OF SILENE TOMENTELLA AND THEIR PHARMACOLOGICAL PROPERTIES

UDC 547.913:543.062

  • Ugiloy Yusufovna Yusupova Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences
  • Nurmurod Sheralievich Ramazonov Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences
  • Khairulla Mamadievich Bobakulov Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences
  • Feruza Rustamovna Egamova Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences
  • Vladimir Nikolaevich Syrov Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences
  • Durbek Abdikhoshimovich Usmanov Институт химии природных соединений. Узбекистан. Ташкент

Аннотация

In thepresent investigation isolation of chemical compounds was carried out from the aerial part of Silene tomentella, an evergreen member of the family Caryophyllaceae, using column chromatography. Identification of chemical compounds was done by various MP, TLC, IR, NMR techniques. The presence of the bioactive compound D-pinitol in this plant is being reported for the first time. Under the influence of D-pinitol, a clear tendency towards normalization of the glycogen content in the liver was also noted (it was only 10.4% lower than in intact animals). In the liver of animals, a rather sharp decrease in the content of glycogen was noted – by 63.5%, and a decrease in the activity of enzymes of the antioxidant defense of the body, characteristic of developing diabetes: SOD – by 35.1, and catalase – by 32.4%. Prophylactically – therapeutic administration of D- pinitol, which exhibits a pronounced ability to inhibit free radical oxidation processes.

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Биографии авторов

Ugiloy Yusufovna Yusupova, Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences

junior researcher

Nurmurod Sheralievich Ramazonov, Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences

doctor of chemical sciences, professor, head of the laboratory of glycoside Chemistry

Khairulla Mamadievich Bobakulov, Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences

senior researcher

Feruza Rustamovna Egamova, Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences

junior researcher

Vladimir Nikolaevich Syrov, Acad. S.Yu.Yunusov Institute of the Chemistry of Plant Substances Uzbek Academy of Sciences

professor, chief researcher

Durbek Abdikhoshimovich Usmanov, Институт химии природных соединений. Узбекистан. Ташкент

junior researcher

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Опубликован
2021-03-16
Как цитировать
1. Yusupova U. Y., Ramazonov N. S., Bobakulov K. M., Egamova F. R., Syrov V. N., Usmanov D. A. BIOLOGICAL ACTIVE COMPONENTS OF SILENE TOMENTELLA AND THEIR PHARMACOLOGICAL PROPERTIES // Химия растительного сырья, 2021. № 1. С. 197-202. URL: http://journal.asu.ru/cw/article/view/8323.
Выпуск
Раздел
Низкомолекулярные соединения