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TY - JOUR AU - Дмитрий Семенович Круглов AU - Виктория Владимировна Величко AU - Айдана Талайбековна Юсупбаева PY - 2023/03/13 Y2 - 2024/11/25 TI - СОДЕРЖАНИЕ АЛКАЛОИДОВ В РАЗЛИЧНЫХ ОРГАНАХ PEGANUM GARMALA L. В ОНТОГЕНЕЗЕ JF - Химия растительного сырья JA - JCPRM VL - 0 IS - 1 SE - Низкомолекулярные соединения DO - 10.14258/jcprm.20230111525 UR - http://journal.asu.ru/cw/article/view/11525 AB - Гармала обыкновенная содержит в своем составе хиназолиновые (L-пеганин (вазицин), пегамин, пеганол, дезоксипеганин, пеганидин др.) и β-карболиновые (гармин, гарман, гармалин, гармалол и др.) алкалоиды, которые обусловливают и различную фармакологическую активность препаратов гармалы. Накопление алкалоидов зависит от стадии онтогенеза и отличается в надземных и подземных частях растения. Цель работы – определить возможность использования различных органов растения для выделения индивидуального алкалоидов.Исследование проводилось на подземных и надземных органах растения, собранного на территории и Республики Кыргызстан в фазах вегетации, цветения и плодоношения.Методами тонкослойной хроматографии и спектрофотометрии было установлено, что в надземной части растения преобладает алкалоид пеганин. В корнях в фазах вегетации и цветения преобладает гармин, а в фазе плодоношения он отсутствует и фиксируется наличие только пеганина. Количественное определение содержания обоих алкалоидов проводилось путем измерения оптической плотности на длинах волн характерных для экстемумов пеганина (266 нм) и гармина (315 нм). В результате было установлено, что содержание пеганина в надземных органах гармалы обыкновенной не зависит от стадии онтогенеза. В то же время содержание алкалоидов в корнях гармалы снижается в онтогенезе с одновременным изменением соотношения гармина и пеганина – в стадиях вегетации и цветения преобладает гармин, а в стадии плодоношения его содержание снижается до следового с одновременным увеличением содержания пеганина. ER -