COMPONENT COMPOSITION AND BIOLOGICAL ACTIVITY OF ESSENTIAL OILS OF GENUS DRACOCEPHALUM L.

Yerlan Melsuly Suleimen, Anar Bazarovna Myrzagaliyeva, Zharkyn Аbykenovich Ibatayev, Zhanar Baktybaevna Iskakova, Talant Nurzhakypovich Samarkhanov, Balzhan Zaruetovna Medeubayeva

Аннотация


This article presents data on the study of the chemical composition, antiradical and cytotoxic activity of three species of the genus Dracocephalum L., which grow in East Kazakstan. Essential oils are obtained from aerial parts of plants D. nutans, D. ruyschiana, D. thymiflorum and the average yield of oil was 0,2%. The chemical composition of essential oils were determined by the GC/MS.

Cytotoxic activity of essential oils was determined by the survival of Artemia salinaaquatic crustaceans. Essential oils of D. nutans, D. ruyschiana and D. thymiflorum in all concentrations (1–10 mg/mL) tested exhibit acute lethal toxicity – all larvae were died. Antiradical activity was determined by the method based on colorimetry of free radicals (DPPH). The experimental results showed that essential oils from D. nutans, D. ruyschiana and D. thymiflorum at all tested concentrations (0,1–1,0 mg/mL) exhibited low antiradical activity compared with the standard drug – butylhydroxyanisole.

 


Ключевые слова


Dracocephalum L.; essential oils; chemical composition; GC/MS; cytotoxic activity; antiradical activity

Полный текст:

PDF (English)

Литература


Egorina A.V., Zinchenko Yu.K., Zinchenko E.S. Physical geography of the Eastern Kazakstan. Oskemen, 2002, 182 p. (in Russ.).

Budantsev A.L. Species of the genus Dracocephalum L. flora of the USSR: systematics, geography, possibilities of use. PhD Thesis. St. Petersburg, 1987, 23 p. (in Russ.).

Recipes of traditional medicine [Internet]. URL: http://nmedic.info/story/zmeegolovnik. (in Russ.).

Pavlov N.V. Flora of Kazakstan. Almaty, 1964, vol. 7, 515 p. (in Russ.).

Misra L.N., Shawl A.S., Raina V.K. Planta Med., 1988, vol. 54, pp. 165–166.

Baiseitova A.M., Aisa H., Jenis J. International Journal of Biology and Chemistry, 2015, vol. 8, pp. 90–97.

Kakasy A.Z. New phytochemical data on Dracocephalum species. Ph.D Thesis. Budapest, 2006, 14 p.

Lemberkovics E., Kakasy A.Z., Héthelyi B.E., Simándi B., Böszörményi A., Balázs A., Szoke E. Acta Pharm Hung, 2007, vol. 77, pp.19–27.

Dr. Duke's Phytochemical and Ethnobotanical Databases [Internet]. U.S. Department of Agriculture, Agricultural Re-search Service. http://phytochem.nal.usda.gov.

State Pharmacopoeia of the USSR, no. 1, General Analytical Methods. Medicinal Plant Raw Material. 11th ed., MH USSR, Moscow, 1990. pp. 290–295. (in Russ.).

Suleimen E.M. Chem. Nat. Compd., 2009, vol. 45, p. 710.

Sawant O., Kadam V.J., Ghosh R. Journal of Herbal Medicine and Toxicology, 2009, vol. 3, pp.39–44.

Sisengalieva G.G., Suleimen E.M., Ishmuratova M.Yu., Iskakova Zh.B., Van Hecke K. Chem. Nat. Compd., 2015, vol. 51, pp. 544–547.




DOI: http://dx.doi.org/10.14258/jcprm.2016041340

Ссылки

  • На текущий момент ссылки отсутствуют.





Контакты: 656049, Барнаул, пр. Ленина, 61, АлтГУ,
редакция журнала "Химия растительного сырья".
Тел./факс: (3852) 29-81-36, e-mail: journal@chemwood.asu.ru.

Контент доступен под лицензией Creative Commons Attribution 3.0 License

Старая версия сайта:http://www.chem.asu.ru/chemwood_old/