Keywords
biologically active substances
biotransformation
plant monoterpenoids
(-)-isopulegol
(-)-trans-carveol
(-)-cis-carveol
(-)-L-carvone
Rhodococcus spp
How to Cite
Abstract
The ability of actinomycete strains of the genus Rhodococcus sencu stricto from the Regional Profiled Collection of Alkanotrophic Microorganisms (official acronym IEGM; UNU/CCP 73559/480868, number 285 in the World Federation of Culture Collections, http://www. iegmcol.ru) to biotransformation of the plant monoterpenoids (-)-isopulegol, (-)-trans-carveol, (-)-cis-carveol, and (-)-L-carvone. The R. rhodochrous strain IEGM 1362, which has the highest targeted catalytic activity, was selected. The conversion of monoterpenoids was accompanied by hydroxylation, carboxylation and dehydration reactions to form carvone, dihydrocarvone, 10-hydroxy- and 10-carboxy-derivatives of (-)-isopulegol and a number of unidentified compounds. In silico analysis of the derivatives obtained showed that the obtained metabolites are highly likely to exhibit antihelminthic, anti-eczemic, vetrogonic, antitumor and immunosuppressive activities, as well as to be used as respiratory analeptic and genitourinary cancer prophylactic agents. Studies aimed at identification of monoterpenoid transformation pathways and determination of functional genes and enzymes encoded by them have been initiated. The data obtained indicate that Rhodococcus rhodococcus is promising for the transformation of monoterpenoids to obtain new biologically active compounds.
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