CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF METABOLITES OF THE GENUS ALHAGI
UDC 547.972:543.42:582.936:615.322:547.913
Abstract
In the review summarized the scientific literature on geographical distribution, the degree of knowledge of the chemical composition and biological activity of extracts and isolated individual compounds of the genus Alhagi Tourn. ex Adans. of the world flora. The structures of the isolated 300 compounds are presented belonging to the alkaloids, terpenoids, carbohydrates, hydrocarbons, lipids, and phenolic compounds. In quantitative terms, the phenolic compounds dominate, among which flavonoids belonging to the group flavone, flavonol, flavanone, isoflavone, isoflavonolignan and flavan-3-ols groups are prevails. Among them, to the chemotoxonomic markers can be include flavonols narcissin and its aglycone isorhamnetin, which are produced in major quantities in practically all species of the genus Alhagi. It was revealed that the qualitative composition of the metabolites of the same species of this genus depends on the ecological-geographical and soil-climatic conditions of their growth place. The data on the biological activity of extracts and isolated individual metabolites are considered. The main biologically active substances of the genus Alhagi are phenolic compounds. The presented information in the review shows that the plants of the genus Alhagi are promising for the creation of new pharmaceuticals. It was noted that in present time are being conducted in-depth preclinical pharmacological studies of the antioxidant preparation "Yantacin", the anti-inflammatory "Alkakhin", the biologically active complex "Alkhidin", and the antioxidant and antibacterial preparation "Zhantharid". Cited in the review information may be used as reference literature by phytochemists, biologists, and pharmacologists.
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Awmack C.S., Lock J.M. Kew Bulletin. 2002. Vol. 57 (2). Pp. 435–443.
Rastitel'nyye resursy SSSR. Tsvetkovyye rasteniya, ikh khimicheskiy sostav, ispol'zovaniye. Semeystva Hydrangeaceae-Haloragaceae. [Plant resources of the USSR. Flowering plants, their chemical composition, use. Hydrangeaceae-Haloragaceae families]. Leningrad, 1987, vol. 3, pp. 103–105. (in Russ.).
The Plant List [Electronic resource]. URL: www.theplantlist.org
Mavlanov Kh. Yantachniki Uzbekistana i puti ikh optimizatsii: avtoref. diss…. dokt. biol. nauk. [Yantachniki of Uz-bekistan and the ways of their optimization: author. diss .... Doct. biol. sciences]. Tashkent, 1998, 36 p. (in Russ.).
Alhagi maurorum Medik. [Electronic resource]. URL: www.legumes-online.net/ildis/aweb/td025/td_05070.htm
Catalogue of Life [Electronic resource]. URL: www.catalogueoflife.org
Flora SSSR. [Flora of the USSR]. Moscow, 1948, vol. 13, pp. 367–373. (in Russ.).
Flora Uzbekistana. [Flora of Uzbekistan]. Tashkent, 1955, vol. 3, pp. 744–749. (in Russ.).
Flora Kazakhstana. [Flora of Kazakhstan]. Alma-Ata, 1961, vol. 5, pp. 446–449. (in Russ.).
Muhammad G., Hussain M.A., Anwar F., Ashraf M., Gilani A-H. Phytotherapy Research, 2015, vol. 29, pр. 1–13. DOI: 10.1002/ptr.5222.
Li N., Zhang G., Xiong Y., Makhabel B., Li X., Jia X. Fitoterapia, 2010,vol. 81 (8), pр. 1058–1061. DOI: 10.1016/j.fitote.2010.06.031.
Mavlanov Kh. Bioraznoobraziye, sokhraneniye i ratsional'noye ispol'zovaniye genofonda rasteniy i zhivotnykh: mate-rialy respublikanskoy konferentsii. [Biodiversity, Conservation and Rational Use of the Plant and Animal Gene Pool: Materials of the Republican Conference]. Tashkent, 2014, pp. 32–33. (in Russ.).
Alimova D.F., Kuliev Z.A., Vdovin A.D. Chem. Nat. Comp., 2007, vol. 43, pp. 326–327. DOI:10.1007/s10600-007-0121-2.
Guo D., Xue W.J., Zou G.A., Aisa H.A. Chem. Nat. Comp., 2016, vol. 52 (6), pp. 1095–1097. DOI:10.1007/s10600-016-1871-5.
Okhundedayev B.S., Bobakulov Kh.M., Nishanbayev S.Z., Abdullayev N.D. Farmatsevticheskiy zhurnal, 2018, no. 1, pp. 37–40. (in Russ.).
Ahmad S., Ahmad I., Saleem M., Jabbar A., Nisar-Ur-Rehman. J. Chem. Soc. Pak., 2009, vol. 31 (6), pp. 960–963.
Marabel B., Xiong Y.J., Jia X.G. Xingiang J. Trad. Chin. Med., 2010, vol. 28 (2), pp. 53–55.
Zhang G.J., Li N., Xiong Y.J., Li X., Li Y., Jia X.G. Zhongguo Yaoxue Zazhi, 2009, vol. 44, pp. 897–899.
Atta-ur-Rahman, Iqbal Choudhary M., Saifullah Bullo. Monograph medicinal plants of Sindh indigenous knowledge and scientific facts. Pakistan, 2011, pр. 49–50.
Sultan A., Moohammadnor M., Eshbakova K.A. Chem. Nat. Comp., 2011, vol. 47 (1),pр. 140–141. DOI: 10.1007/s10600-011-9860-1.
Awad Amani A.S., Maitland D.J., Soliman G.A. Pharm. Biology., 2006, vol. 44 (4),pр. 292–296. DOI: 10.1080/13880200600714160.
Behzad S., Pirani A., Mosaddegh M. Iranian J. Pharm. Res., 2014, vol. 13, pр. 199–205.
Laghari A.H., Memon Sh., Nelofar A., Khan Kh.M., Yasmin A., Syed M.N., Aman A. J. Molec. Struc., 2010, vol. 965, pp. 65–67. DOI: 10.1016/j.molstruc/2009.11.039.
Nishanbayev S.Z., Bobakulov Kh.M., Beshko N.Yu., Sham'yanov I.D., Abdullayev N.D. Khimiya rastitel'nogo syr'ya, 2017, no. 1, pp. 77–83. DOI: 10.14258/jcprm.2017011386. (in Russ.).
Novruzov E.N., Abdullaeva G.A., Shamsizade L.A., Mustafaev N.Sh. Chem. Nat. Comp., 2009, vol. 45 (2), pр. 249–250. DOI: 10.1007/s10600-009-9287-0.
Hui Q.Zh., Thai X. Jilin J. Trad. Chin. Med., 2009, vol. 29 (8), pp. 711–712.
Novruzov E.N., Abdullayeva G.A., Mustafayev N.Sh., Rasulov F.A. Rastitel'nyye resursy, 2010, vol. 46, no. 4, pp. 91–97. (in Russ.).
Sapko О.А., Kunaeva R.M. Chem. Nat. Comp., 1999, vol. 35 (2), pр. 162–164. DOI: 10.1007/bf02234924.
Eskalieva B.K., Burasheva G.Sh. Chem. Nat. Comp., 2002, vol. 38, pр. 102–103. DOI: 10.1023/A:1015710621895.
Ibrahim M.T. J. Americ. Sci., 2015,vol. 11 (5), pр. 1–7.
Xiuwei Y., Yumei J., Junshan L. Chin. Trad. and Herb. Drugs, 1996, vol. 27 (12), pp. 707–711.
Guijie Zh., Ning L., Yuanjun X., Makhabel B., Jinhui W., Xian L., Xiaoguang J. Modern Chin. Med., 2010,vol. 12(5), pp. 16–19.
Su X.C, Chen L., Aisa H.A.Chem. Nat. Comp., 2008,vol. 44 (3), p. 365. DOI: 10.1007/s10600-008-9064-5.
Burasheva G.Sh., Mukhamed'yarova M.M., Chumbalov T.K. Chem. Nat. Comp., 1976, vol. 5, p. 596. DOI: 10.1007/bf00565206.
Ahmad S., Riaz N., Saleem M., Jabbar A., Nisar-Ur-Rehman, Ashraf M. J. Asian Nat. Prod. Res., 2010, vol. 12 (2),pp. 138–143. DOI: 10.1080/10286020903451724.
Alimova D.F., Eshbakova K.A., Bobakulov Kh.M., AbdullaevN.D.Chem. Nat. Comp., 2013,vol. 49 (3), pp. 437–439. DOI: 10.1007/s10600-013-0632-y.
El-SayedN.H., Ishak M.S., Kandil F.I., Mabry T.J. Pharmazie, 1993,vol. 48,pp. 68–69.
Burasheva G.Sh, Mukhamed'yarova M.M., Tchumbalov T.K. Chem. Nat. Comp., 1977, vol. 2, p. 242. DOI: 10.1007/bf00563963.
Burasheva G.Sh, Mukhamed'yarova M.M., Tchumbalov T.K. Chem. Nat. Comp., 1975, vol. 3, p. 441. DOI: 10.1007/bf00571238.
Burasheva G.Sh, Mukhamed'yarova M.M., Tchumbalov T.K. Chem. Nat. Comp., 1975, vol. 2, p. 261. DOI: 10.1007/bf00570690.
Singh V.P., Yadav B., Pandey V.B. Phytochemistry, 1999, vol. 51, pp. 587–590. DOI: 10.1016/S0031-9422(99)00010-2.
Nishanbayev S.Z., Bobakulov Kh.M., Sasmakov S.A., Aripova S.F. Farmatsevticheskiy zhurnal, 2018, no. 1, pp. 26–29. (in Russ.).
Srivastava B., Sharma H., Nandan Dey Y., Wanjari M.M., Jadhav A.D. Inter. J. Herbal Medic., 2014,vol. 2 (2),pр. 47–51.
Islambekov Sh.Yu., Mirzakhidov Kh.A., Karimdzhanov A.K., Ishbaev A.I. Chem. Nat. Comp., 1982,vol. 5,pp. 620–621. DOI: 10.1007/bf00575060.
Malik A., Kuliev Z.A., Akhmedov U.A., Vdovin A.D., Abdullaev N.D. Chem. Nat. Comp., 1997, vol. 33 (2), pp. 174–178. DOI: 10.1007/bf02291536.
Alimova D.F., Nishanbaev S.Z., Kuliev Z.A., Vdovin A.D., Abdullaev N.D., Aripova S.F. Chem. Nat. Comp., 2010, vol. 46 (3), pp. 352–356. DOI: 10.1007/s10600-010-9615-4.
Wagay N.A., Mohiuddin Y.G., Khan N.A. Inter. J. Adv. Res. in Sci. and Engin., 2018, vol. 7 (4), pp. 300–311.
Ghosal S., Srivastava R.S. J. Pharm. Sci., 1973,vol. 62 (9),pp. 1555–1556. DOI: 10.1002/jps.2600620942.
Zou G.A., Mansur S., Hu S.C., Aisa H.A., Shakhidoyatov Kh.M. Chem. Nat. Comp., 2012, vol. 48 (4), pp. 635–637. DOI: 10.1007/s10600-012-0330-1.
Nishanbaev S.Z., Bobakulov Kh.M., Okhundedaev B.S., Sasmakov S.A., Yusupova E., Azimova Sh.S., Abdul-laev N.D. Nat. Prod. Res., 2019, vol. 33(23), pp. 3417–3420. DOI: 10.1080/14786419.2018.1475384.
Nishanbaev S.Z., Bobakulov Kh.M., Nigmatullaev A.M., Shamyanov I.D., Ohundedaev B.S., Abdullayev N.D. Chem. Nat. Comp., 2016, vol. 52 (1), pp. 167–170. DOI: 10.1007/s10600-016-1582-y.
Samejo M.Q., Memon S., Bhanger M.I., Khan K.M. Chem. Nat. Comp., 2012, vol. 48 (5), pp. 898–900. DOI: 10.1007/s10600-012-0417-8.
Mamatkulova N.M., Alimova D.F., Nishanbaev S.Z., Mukarramov N.I., Khidyrova N.K. Chem. Nat. Comp., 2012, vol. 48, pp. 908–909. DOI: 10.1007/s10600-012-0421-z.
Aypesheva R.S. Issledovaniye kompleksa biologicheski aktivnykh komponentov iz ekstrakta semyan verblyuzh'-yey kolyuchki (Alhagi pseudalhagi (Bieb) Fisch): nauchno-issledovatel'skaya rabota. [Study of a complex of biologically active components from an extract of seeds of a camel thorn (Alhagi pseudalhagi (Bieb) Fisch): research work]. As-trakhan', 2009, 30 p. (in Russ.).
Hamed A., Perrone A., Mahalel U., Oleszek W., Stochmal A., Piacente S. Phytochemistry Let., 2012, vol. 5, pp. 782–787. DOI: 10.1016/j.phytol.2012.09.002.
Laghari A.H., Memon S., Nelofar A., Khan K.M. Indus. Crops and Prod., 2011, vol. 34 (1), pp. 1141–1145. DOI: 10.1016/j.indcrop.2011.03.031.
Behari M., GuplaS.C.Curr. Sci. (India), 1981,vol. 50 (11),pp. 485–486.
Marashdah M.S.Arabian J. Chem., 2014, vol. 7, pр. 381–383. DOI: 10.1016/j.arabjc.2013.11.041.
Rakhimov D.R., Dzhumamuratova A. Chem. Nat. Comp., 1993,vol. 29 (5),pp. 674–675. DOI: 10.1007/bf00630223.
Besset C., Chambert S., Queneau Y., Kerverdo S., Rolland H., Guilbot J. Carbohyd. Res., 2008, vol. 343, pр. 929–935. DOI: 10.1016/j.carres.2008.01.041.
Abdel Azeiz A.Z., Shehata M.S. Curr. Bioac. Comp., 2018, vol. 14 (2), pp. 205–208. DOI: 10.2174/1573407213666170221160337.
Laghari A.H., Memon A.A., Memon Sh., Nelofar A., Khan Kh.M., Yasmin A. Nat. Prod. Res., 2012, vol. 26 (2), pp. 173–176. DOI: 10.1080/14786419.2010.538846.
Demir E., Laghari A.H., Sokmen M., Memon Sh. Separ. Sci. and Technol., 2015, vol. 50 (4), pp. 529–535. DOI: 10.1080/01496395.2014.956763.
Gudvin T., Merser E. Vvedeniye v biokhimiyu rasteniy. V 2-kh t. [Introduction to plant biochemistry. In 2 vols.]. Mos-cow, 1986, vol. 1, 393 p. (in Russ.).
Semenov A.A., Kartsev V.G. Osnovy khimii prirodnykh soyedineniy. [Fundamentals of the chemistry of natural com-pounds]. Moscow, 2009, vol. 1, 624 p. (in Russ.).
Kholmatov Kh.Kh. Rastitel'nyye resursy, 1973, vol. 9, no. 2, pp. 161–167. (in Russ.).
Al-Snafi A.E. Inter. J. Pharm. Rev. & Res., 2015,vol. 5 (2), pр. 130–136.
Varshochi F., Asadollahi Kh. J. Nephropharmacology, 2017, vol. 6 (1), pр. 15–16.
Rastitel'nyye resursy. Rossii i sopredel'nykh gosudarstv. Chast' 2. Dopolneniya k 1-7 tomam. [Plant resources. Russia and neighboring states. Part 2. Additions to 1-7 volumes]. St. Petersburg, 1996, vol. 9, pp. 213–214. (in Russ.).
Suthar P., Mathur K., Goyal M., Yadav S.K. World J. Pharm. and Pharmacy. Sci., 2016, vol. 5 (4), pp. 682–692.
Irgasheva Sh.B. Rastitel'nyye lekarstvennyye sredstva. [Herbal medicines]. Tashkent, 2003, pp. 291–292. (in Russ.).
Abdul Khafiz Abdelati Issam Yosef. Issledovaniya razvitiya i vydeleniye ekstraktov i efirnykh masel aira bolotnogo i verblyuzh'yey kolyuchki, proizrastayushchikh v Astrakhanskoy oblasti: avtoref. dis. ... kand. biol. nauk. [Studies of the development and isolation of extracts and essential oils of calamus swamp and camel spines, growing in the Astrakhan region: author. dis. ... cand. biol. sciences]. Astrakhan', 2011, 22 p. (in Russ.).
Makhlayuk V.P. Lekarstvennyye rasteniya v narodnoy meditsine.[Medicinal plants in traditional medicine]. [Electronic resource]. URL: http://bibliotekar.ru/lekarstvennye/2/6.htm (in Russ.).
Gammerman A.F., Kadayev G.N., Yatsenko-Khmelevskiy A.A. Lekarstvennyye rasteniya (Rasteniya-tseliteli). [Me-dicinal Plants (Healing Plants)]. Moscow, 1990, 544 p. (in Russ.).
Ahmad N., Bibi Y., Saboon, Raza I., Zahara K., Idrees S., Khalid N., Bashir T., Tabassum Sh., Mudrikah. Asian Pac. J. Trop. Dis., 2015, vol. 5 (11), pр. 856–861. DOI: 10.1016/S2222-1808(15)60945-8.
Asghari M.H., Fallah M., Moloudizargari M., Mehdikhani F., Sepehrnia P., Moradi B. Ancient Sci. of Life, 2016, vol. 36 (2), pp. 65–71. DOI: 10.4103/asl.ASL_37_16.
Marashdah M.S., Farraj A.I. J. Saudi Chem. Soc., 2010, vol. 14, pр. 247–250. DOI: 10.1016/j.jscs.2010.02.015.
Bhavana Srivastava, Himanshu Sharma, Yadu Nandan Dey, Manish M Wanjari, Ankush D Jadhav. // International Journal of Herbal Medicine. 2014. vol. 2 (2). pp. 47–51.
Ali-Shtayeh M.S., Yaniv Z., Mahajna J. J. Ethnopharmacol., 2000, vol. 73 (1), pр. 221–232. DOI: 10.1016/s0378-8741(00)00316-0.
Bahmani M., Baharvand-Ahmadi B., Tajeddini P., Rafieian-Kopaei M., Naghdi N. J. Renal Inj. Prev., 2016, vol. 5(3), pр. 129–133.
Neamah N.F. Global J. Pharmacol., 2012, vol. 6 (1), pр. 41–46.
Michnik L.A., Osman M., Michnik O.V. Issledovaniye biologicheskoy aktivnosti travy verblyuzh'yey kolyuchki (Alhagi pseudalhagi). Novyye lekarstvennyye preparaty iz rasteniy Sibiri i Dal'nego Vostoka. [A study of the biological activity of camelle grass (Alhagi pseudalhagi). New drugs from plants in Siberia and the Far East]. Tomsk, 1989, 113 p. (in Russ.).
Gharib Naseri M.K., Ali Mard S. Pakistan J. Med. Sci., 2007, vol. 23 (4), pр. 570–573.
Sidibe A. Farmakologicheskoye izucheniye izvlecheniy iz nadzemnoy chasti verblyuzh'yey kolyuchki Alhagi pseudalhagi (Bieb.) Desv.: avtoref. diss. … kand. farm. nauk. [Pharmacological study of extracts from the aerial part of the camel spine Alhagi pseudalhagi (Bieb.) Desv .: abstract. diss. ... cand. farm. sciences]. St. Petersburg, 2003, 24 p. (in Russ.).
Sivak K.V., Kovalenko A.L. Klinicheskiye i eksperimental'nyye issledovaniya, 2007, no. 1 (8), pp. 105–108. (in Russ.).
Amirkulova M.K., Ustenova G.O., Pichkhadze G.M. Mezhdunarodnaya nauchno-prakticheskaya konferentsiya «Innovatsiya v farmakologii – dostizheniya i perspektivy». [International scientific-practical conference "Innovation in pharmacology - achievements and prospects"]. Alma-Ata, 2013, pp. 17–18. (in Russ.).
Sulaiman G.M. African J. Microb. Res., 2013,vol. 7 (16), pp. 1548–1557.
Kumarova A.K., Bevz N.Yu., Strelets O.P. Retsept, 2016, no. 4, pp. 19–25. (in Russ.).
Olas B., Hamed A.I., Oleszek W., Stochmal A. Platelets, 2015,vol. 26 (8), pp. 788–794. DOI: 10.3109/09537104.2015.1031650.
Abdul-Hafeez E.Y., Mahmoud A.F., Ibrahim O.H.M. Assiut J. Agric. Sci., 2015, vol. 46 (5), pp. 33–47. DOI: 10.21608/AJAS.2016.530.
Al-Massarani Sh., El Dib R. Pakistan J. Pharm. Sci., 2015, vol. 28 (3), pp. 1079–1096.
Korystova A.F., Kublik L.N., Levitman M.Kh., Shaposhnikova V.V., Appazov N.O., Narmanova R.A., Ibadullaye-va S.Zh., Korystov Yu.N. Byulleten' eksperimental'noy biologii i meditsiny, 2014, no. 8, pp. 55–58. (in Russ.).
Shaker E., Mahmoud H., Mnaa S. Food and Chem. Tox., 2010, vol. 48 (10), pp. 2785–2790. DOI: 10.1016/j.fct.2010.07.007.
Al-Snafi A.E. Indian J. Pharm. Sci. & Res., 2015, vol. 5 (4), pр. 220–232.
Chakrapani B., Abdul Ahad H., Ravichandran D., Swaroop D., Babu M. Inter. J. Pharm. and Nat. Med., 2013, vol. 1(1), pр. 44–51.
Gargoum H.M., Muftah S.S., Al Shalmani S., Mohammed H.A., Alzoki A.N., Debani A.H., Al Fituri O., El Shari F., El Barassi I., Meghil S.E., Awad G.A. J. Sci. and Innov. Res., 2013, vol. 2 (6), pр.1023–1033.
Muhammad G., Asghar M.N., Ahmad M., Kashmiri M.A., ZiaI.Asian. J. Chem., 2011, vol. 23 (3), pр. 971–976.
Bashirova N.S., Khushbaktova Z.A., Paleoluga A.K., Shadiyeva Z.Kh., Ol'khovaya V.N., Syrov V.N. Meditsinskiy zhurnal Uzbekistana, 1987, no. 5, pp. 60–63. (in Russ.).
Bashirova N.S., Khushbaktova Z.A., Shadiyeva Z.Kh., Usmankhodzhayeva A.I., Ol'khovaya V.N., Syrov V.N. Me-ditsinskiy zhurnal Uzbekistana, 1989, no. 4, pp. 57–58. (in Russ.).
Khushbaktova Z.A., Syrov V.N., Khalikov T.R., Vaysbrot V.V., Tadzhiyev B.A. Meditsinskiy zhurnal Uzbekistana, 1988, no. 6, pp. 66–69. (in Russ.).
Patent 2402345 (RU). 27.10.2010.(in Russ.).
Gaybullaev А., Kariev S. Medical and Health Sci. J., 2012, vol. 10, pp. 74–80.
Atta A.H., Mouneir S.M. J. Ethnopharm., 2004, vol. 92 (2), pр. 303–309. DOI: 10.1016/j.jep.2004.03.017.
Sulaiman G.M. African J. Microb. Res., 2013, vol. 7(16), pp. 1548–1557. DOI: 10.5897/AJMR12.1795.
Laghari A.H., Shahabuddin M., Aisha N., Khan Kh.M. Anal. Let., 2014, vol. 47, pр. 413–421. DOI: 10.1080/00032719.2013.841178.
Loizzo M.R., Khaled R., Ataa S., Marco B., Francesco M., Rosa T. Industrial Crops and Products, 2014, vol. 53, pp. 289–295. DOI: 10.1016/j.indcrop.2013.12.049.
Dolotkazin D.R. Materialy dokladov V Mezhdunarodnoy nauchnoy konferentsii. [Materials of reports of the V Inter-national scientific conference]. Moscow, 2013. pp. 154–155. (in Russ.).
Nishanbayev S.Z., Sham'yanov I.D., Khushbaktova Z.A., Syrov V.N. Infektsiya, immunitet i farmakologiya, 2017, no. 3, pp. 152–159. (inRuss.).
Rakhimov K.D., Burasheva G.Sh., Gulyayev A.Ye. Doklady Natsional'noy akademii nauk Respubliki Kazakhstan, 2015, no. 1, pp. 93–100. (inRuss.).
BurashevaG.Sh., RakhimovK.D., AbilovZh.A. Biologicheskiyaktivnyykompleks – alkhidiniyegofarmakologi-cheskayaaktivnost'. [The biological active complex is alchidine and its pharmacological activity]. Almaty, 2001, 180 p. (in Russ.).
Rakhimov K.D., Burasheva G.Sh., Gulyayev A.Ye., Nurgozhin T.S. Vestnik Natsional'noy akademii nauk Respubliki Kazakhstan, 2012, no. 4, pp. 26–33. (in Russ.).
Sokolik V.I., Shestakov F.V. News of the Nat. Acad. of Sci. of the republic of Kazakhstan series of boil. and medical, 2015, vol. 65 (312), pp. 146–153.
Rakhimov K.D. Izvestiya NAN RK. Seriya biologicheskaya i meditsinskaya, 2016, no. 4, pp. 67–71. (in Russ.).
Muslimova D.N., Burasheva G.Sh., Rakhimov K.D., Abilov Zh.A. Izvestiya nauchno-tekhnicheskogo obshchestva «Kakhak», 2013, no. 3 (42), pp. 31–34. (in Russ.).
Tarakhovskiy Yu.S., Kim Yu.A., Abdrasilov B.S., Muzafarov Ye.N. Flavonoidy: biokhimiya, biofizika, meditsina. [Flavonoids: biochemistry, biophysics, medicine]. Pushchino, 2013, 310 p. (in Russ.).
Korul'kin D.Yu., Abilov Zh.A., Muzychkina R.A., Tolstikov G.A. Prirodnyye flavonoidy. [Natural flavonoids]. No-vosibirsk, 2007, 232 p. (in Russ.).
Semenov A.A., Kartsev V.G. Biologicheskaya aktivnost' prirodnykh soyedineniy. [The biological activity of natural compounds]. Moscow, 2012, 520 p. (in Russ.).
Kul'zhanov Z.A., Amanzhulova K.S. Vliyaniye flavonoidnykh fitopreparatov na regionarnuyu gemodinamiku. Rat-sional'noye ispol'zovaniye rastitel'nykh resursov Kazakhstana. [The effect of flavonoid phytopreparations on regional hemodynamics. Rational use of plant resources of Kazakhstan]. Alma-Ata, 1986, pp. 339–341. (in Russ.).
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