INVESTIGATION AND OPTIMIZATION OF COMPLEXATION OF MANGANESE (II) IONS WITH DIHY-DROQUERCETIN IN AQUEOUS SOLUTIONS
UDC 543.641:546.712:547.575:543.427.4:543.573
Abstract
The purpose of this work was to study and optimize the complexation reaction of Mn2+ ions with flavonoid dihydroquercetin (DHQ) in aqueous solutions. It was found that the interaction of DHQ (0.015–0.030 M) with manganese (II) salts at molar ratios of DHQ : Mn2+ from 1 : 1 to 1 : 3 at pH 6.9–7.9 leads to the formation of a complex compound (CC) with a stoichiometric ratio of metal : flavonoid ligand (Met : L) 1 : 1.
The conditions for the complexation of Mn2+ ions with dihydroquercetin at laboratory conditions optimized for the yield of the product, are proposed. The maximum yield of the complex (95%) was achieved at the interaction of DHQ with Mn(CH3COO)2∙4H2O under conditions: pH 7.7, 70 °C, the reaction time was 15 min, the molar ratio of the initial reagents DHQ: Mn2+ was 1 : 1.5, the initial concentrations were 0.020 M DHQ and 0.030 M Mn2+.
The most probable composition of the complex with the determination of the amount of bound water [MnL(OH)(H2O)2] and the structure of the complex were established using the data of thermogravimetry (TG), differential scanning calorimetry (DSC), elemental analysis and X-ray fluorescence analysis (XRF), confirmed by the data of total reflection X-ray fluorescence analysis (TXRF), and EPR spectroscopy data.
Downloads
Metrics
References
Korochkina Ye.A. Genetika i razvedeniye zhivotnykh, 2016, no. 3, pp. 69–73. (in Russ.).
Filippova V.A., Lysenkova A.V. Problemy zdorov'ya i ekologii, 2013, no. 4 (38), pp. 72–78. (in Russ.).
Agadzhanyan N.A., Skal'nyy A.V., Detkov V.Yu. Ekologiya cheloveka, 2013, no. 11, pp. 3–12. (in Russ.).
Bakhtina G.G., Len'ko O.A., Sukhanova S.Ye. Patologiya krovoobrashcheniya i kardiokhirurgiya, 2007, no. 4, pp. 82–89. (in Russ.).
Zhang D.W., Cheng Y., Zhang J.Ch., Wang X.L., Wang N.L., Chen Y., Yang M.S., Yao X.Sh. Chinese Science Bulle-tin, 2008, vol. 53, no. 3, pp. 347–356. DOI: 10.1007/s11434-007-0485-5.
Nazari M., Zarinkamar F., Niknam V. Environmental Science and Pollution Research, 2018, vol. 25, pp. 7575–7588. DOI: 10.1007/s11356-017-0889-y.
Satterfield M., Brodbelt J.S. Analytical Chemistry, 2000, vol. 72, no. 24, pp. 5898–5906.
Bravo A., Anacona J.R. Transition Metal Chemistry, 2001, vol. 26, pp. 20–23.
Chen X., Tang L.-J., Sun Y.-N., Qiu P.-H., Liang G. Journal of Inorganic Biochemistry, 2010, vol. 104, pp. 379–384.
Qian J.-Z., Wang B.-C., Fan Y., Tan J., Yang X. Journal of Structural Chemistry, 2015, vol. 56, no. 2, pp. 338–345. DOI: 10.1134/S0022476615020195.
Patent 2158598 (RU). 2000. (in Russ.).
Gosudarstvennaya farmakopeya Rossiyskoy Federatsii, XIII izd. [State Pharmacopoeia of the Russian Federation, XIII ed.]. Moscow, 2015, vol. 1, pp. 531–534. (in Russ.).
Poole C.P. Electron Spin Resonance: A Comprehensive Treatise on Experimental Techniques, 2nd ed. Dover Publica-tions, Dover, 1997, 810 р.
Babkin V.A., Ostroukhova L.A., Trofimova N.N. Biomassa listvennitsy: ot khimicheskogo sostava do innovatsi-onnykh produktov. [Larch biomass: from chemical composition to innovative products]. Novosibirsk, 2011, 236 p. (in Russ.).
Trofimova N.N., Stolpovskaya E.V., Babkin V.A., Fedorov S.V., Kalabin G.A., Goryainov S.V., Zolotarev E.E., Saf-ronov A.Yu., Kashevskii A.V., Zhitov R.G. Russian Journal of Bioorganic Chemistry, 2015, vol. 41, no. 7, pp. 745–752. DOI: 10.1134/S1068162015070146.
Trofimova N.N., Babkin V.A., Kiselev O.I. Izvestiya Akademii nauk. Seriya khimicheskaya, 2015, no. 6, pp. 1430–1436. (in Russ.).
Stolpovskaya E.V., Trofimova N.N., Babkin V.A. Russian Journal of Bioorganic Chemistry, 2017, vol. 43, no. 7, pp. 52–56. DOI: 10.1134/S1068162017070160.
Patent 2637440 (RU). 2017. (in Russ.).
Stolpovskaya Ye.V., Trofimova N.N., Babkin V.A., Zhitov R.G. Khimiya rastitel'nogo syr'ya, 2019, no. 1, pp. 95–104. DOI: 10.14258/jcprm.2019014257. (in Russ.).
Zenkevich I.G., Yeshchenko Yu.A., Makarov V.G., Kolesnik Yu.A., Shmatkov D.A., Tikhonov V.P., Tashlitskiy V.M. Aktual'nyye problemy sozdaniya novykh lekarstvennykh preparatov prirodnogo prois-khozhdeniya. Fitofarm-2006: materialy X mezhdunarodnogo s"yezda. [Actual problems of creating new medicinal preparations of natural origin. Fitofarm-2006: materials of the X international congress]. St. Petersburg, 2006, pp. 93–109. (in Russ.).
Chervyakovskiy Ye.M., Kurchenko V.P., Kostyuk V.A. Trudy BGU, 2009, vol. 4, pp. 9–26. (in Russ.).
Heim K.E., Tagliaferro A.R., Bobilya D.J. Journal of Nutritional Biochemistry, 2002, vol. 13, pp. 572–584.
De Souza R.F.V., De Giovani W.F. Spectrochimica Acta Part A, 2005, vol. 61, pp. 1985–1990.
Cornard J.P., Merlin J.C. Journal of Inorganic Biochemistry, 2002, vol. 92, pp. 19–27.
Zheltoukhova Ye.P., Koval'chukova O.V., Zaytsev B.Ye., Strashnova S.B. Novyye dostizheniya v khimii i khimicheskoy tekhnologii rastitel'nogo syr'ya: materialy IV Vserossiyskoy konferentsii. [New achievements in the chemistry and chemical technology of plant raw materials: materials of the IV All-Russian conference]. Barnaul, 2009, vol. 2, pp. 217–218. (in Russ.).
Torreggiani A., Tamba M., Trinchero A., Bonora S. Journal of Molecular structure, 2005, vol. 744–747, pp. 759–766.
Cornard J.P., Boudet A.C., Merlin J.C. Spectrochimica Acta Part A, 2001, vol. 57, no. 3, pp. 591–602.
Vyaznikova M.Yu., Nikolayeva S.S., Smirnova L.P., Bykov V.A. Khimiko-farmatsevticheskiy zhurnal, 1997, vol. 31, no. 2, pp. 39–41. (in Russ.).
Selifonova Ye.I., Chernova R.K., Koblova O.Ye. Izvestiya Saratovskogo universiteta. Novaya seriya. Seriya: Khimiya. Biologiya. Ekologiya, 2008, vol. 8, no. 2, pp. 23–28. (in Russ.).
Galyametdinov Yu.G., Sagdeev D.O., Sukhanov A.A., Voronkova V.K., Shamilov R.R. Photonics, 2019, vol. 6, no. 107, pp. 1–8. DOI: 10.1117/12.2530906.
Manzan R.S., Donoso J.P., Magon C.J., Silva I.A.A., Rüssel C., Nalin M. J. Braz. Chem. Soc., 2015, vol. 26, no. 12, pp. 2607–2614. DOI: 10.5935/0103-5053.20150289.
Möncke D., Ehrta D., Kamitsosb E.I. Phys. Chem. Glasses: Eur. J. Glass Sci. Technol. B, 2013, vol. 54, no. 1, pp. 42–51.
Slinkin A.A., Kucherov A.V., Aleshin E.G. Kinetika i kataliz, 1997, vol. 38, pp. 774–779. (in Russ.).
Rabinovich V.A., Khavin Z.Ya. Kratkiy khimicheskiy spravochnik. [A short chemical reference book]. Leningrad, 1978, 392 p. (in Russ.).
Roshal' A.D., Sakhno T.V. Vestnik Khar'kovskogo natsional'nogo universiteta. Khimiya, 2001, vol. 532, no. 7(30), pp. 123–129. (in Russ.).
![](http://journal.asu.ru/public/journals/1/article_7369_cover_ru_RU.png)
Copyright (c) 2020 chemistry of plant raw material
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.