DEVELOPMENT OF METHODS OF QUALITY CONTROL OF GINSENG TINCTURA
Abstract
There were developed the techniques of qualitative and quantitative analysis of ginseng tinctures (Panax ginseng C.A. Meyer).
Thin-layer chromatography (in the solvent system chloroform – methanol – water, 26 : 14 : 3; detection in the visible range after reaction with phosphowolframic acid) and UV/Visible spectroscopy of native tincture (maximum of absorption at 268±2 nm) and total saponins, purified on polyamide and reacted with 70% sulphuriс acid (maximum of absorption at 280±2 nm, 400±2 nm and 526±2 nm).
The method of quantitative determination of total saponins in tinctura of ginseng by means of direct spectrophotometry (analytical wave-length at 526 nm) was developed. The contents of the total saponins are varied with 0,42% to 0,61% (calculated on ginsenoside Rg1)Downloads
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References
Государственный реестр лекарственных средств [Электронный ресурс]. 2011. URL: http://grls.rosminzdrav.ru/grls.aspx.
Куркин В.А. Фармакогнозия: учебник для студентов фармацевтических вузов (факультетов.). 2-е изд., перераб. и доп. Самара, 2007. 1239 с.
Куркин В.А. Основы фитотерапии: учеб. пособие для студентов фармацевтических вузов. Самара, 2009. 963 с.
Машковский М.Д. Лекарственные средства: в 2 т. М., 2008. 1206 с.
Справочник Видаль. Лекарственные препараты в России: справочник. М., 2011. 1728 с.
Государственная фармакопея СССР. Вып. 2: Общие методы анализа. Лекарственное растительное сырье / МЗ СССР. 11-е изд., доп. М., 1990. 400 с.
European Pharmacopoeia. 6-th Ed. Rockville: United States Pharmacopoeial Convention. Inc., 2008. Pp. 738–739.
Фармакопея США: USP 29. Национальный формуляр: NF 24: в 2 т. [пер. с англ.]. М., 2009. Т. 2. С. 2226.
ФС 42-10675-00. Настойка женьшеня / Фармакопейный государственный комитет. Введ. 19.01.2000. М., 2000. 5 с.
Глебко Л.И., Красовская Н.П., Покушалова Т.В., Ильченко Г.Я., Будина Т.А. Стандартизация качества женьшеня корней и настойки по содержанию суммы гинзенозидов // Химико-фармацевтический журнал. 2004. №4. С. 20–23.
Japanese Pharmocopoeia. JP XIV. 2001. Pp. 927–930.
German Homoeopathic Pharmacopoeia. Stuttgart, 1993. Pp. 303–306.
Wagner H., Blads S. Plant Drug Analysis. A Thin Layer Chromatography Atlas. Berlin; Heidelberg; New York, 1996. 348 p.
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