MASS SPECTROMETRY SUPRAMOLECULAR COMPLEXES GLYCYRRHIZIC ACID, AND STREPTOMYCIN
Abstract
Glycyrrhizic acid (HA) isolated from the roots of licorice Glycyrrhiza glabra L. and Gl. uralensis F. has unique complexing properties, which are widely used in the synthesis of new dosage forms on the basis of molecular complexes with Pharmakon. In such heterogeneous complexes HA molecules act as ligands polidentantnyh forming a supramolecular Pharmakon com-plexes with different stoichiometry. The aim of this work is to study the complexation of plant glycosides with antimicrobials streptomycin to create new low-dose pharmaceutical substances on the basis of glycyrrhizic acid. In this study first synthesized and studied by UV-spectroscopy and mass spectrometry with electrospray ionization heterogeneous supramolecular complexes HA antibiotic streptomycin (ST) obtained at different concentrations of "host" and "guest" in the ratio 1 : 1 and 4 : 1. registered changes in the absorption spectrum of CT in the presence of HA by UV spectroscopy proves the formation of heterogeneous ST HA-complexes in the liquid phase. Using mass spectrometry registered effective interaction of HA and PT various heterogeneous form supramolecular structures with an aspect ratio "host : guest" 1 : 1, 2 : 1, 3 : 1, 3 : 2. By increasing HA concentration was observed as an increase in the degree of self-association of HA (up to 4) and complex formation with a ratio 4 : 1. The results of studies show a high potential for the use of glycyrrhizic acid synthesis of new antibiotic streptomycin forms a noncovalent molecular complexes.Downloads
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