EFFECT OF 1,5-BIS(3,5-DIMETHYLPYRAZOL-1-YL)-3-OXAPENTANE DIACETATOCOPPER ON THE STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF THE LIVER AND PANCREAS IN RATS UNDER EXPERIMENTAL CONDITIONS
Abstract
Various factors including chemical substances affecting on the human and animal organisms, causing a series of changes in the structural and metabolic processes. Chemical compounds cause a violation in the homeostatic regulatory systems, liver function and also influences the metabolism of hormones produced by the gonads in experimental animals. These studies suggest that, the intraperitoneal administration rats by 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper (dose 12 mg per kg of body weight for 6 weeks) led to disturbance of the normal structure of the liver and pancreas. This drug caused intensively neutrophilic infiltration around venous vessels with bleeding, endoplasmic vacuolation of most cells, karyopyknosis, karyorrhexis, and karyolysis, as well as, increasing the amount of binucleated cells. This treatment led to a reduction in the total protein content in the tissue of liver and pancreas, as well as activation of the apoptotic process in liver cells.
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Lu, Y., Cederbaum, A.I. (2006). Enhancement by pyrazole of lipopolysaccharide–induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Hepatol., 44(1), 263–274.
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Pearse, A.G.E. (1972). Histochemistry, Theoretical and Applied. London: Churchill Livingstone.
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Potapov, A.S., Nudnova, E.A., Domina G.A., Kirpotina, L.N., Quinn, M.T., Khlebnikov, A.I., Schepetkin, I.A. (2009). Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)-2,2-bipyridyl mixed ligand copper(II) complexes. Dalton Trans., 23, 4488–4498.
Sakr, S.A., El-Mesady, F.A., El-Desouki, N.I. (2002). Pyrethriod inhalation induced histochemical changes in the liver of Albino rats. The Sciences, 2(1), 24–28.
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Składziński, J., Beskid, M. (1978). Combined action of pyrazole and ethanol on a rat liver: histochemical and ultrastructural study. Fol. Histochem. and Cytochem., 16(1), 13–18.
Talman, P. (1979). Measurement of peripheral nerve regeneration in the rat and the effects of pyronin or hypothyroidism. Exp. Neurol., 65, 535–541.
Yamada, M., Murawaki, Y., Hirayama, C. (1987). Effects of ethanol feeding on collagen synthesizing and degrading enzymes in rat pancreas. Biochem. Pharmacol., 36(20), 3361–3364.
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