SYNERGY OF TRADITIONAL AND MODERN APPROACHES TO THE SEARCH AND STUDY OF PROMISING NATURAL-ORIGIN DRUG CANDIDATES (HISTORY, CHALLENGES, SOLUTIONS):

Vladimir Gennadievich  Luzhanin; Natalia Eduardovna  Kolomiets; Yaroslav Evgenievich  Reshetov; Andrey Kenneth Waillie; Anastasia Olegovna Weilly; Roman Sergeevich Boev; Mikhail Valerievich  Belousov

doi:10.14258/jcprm.20250114852

Vladimir Gennadievich Luzhanin Perm State Pharmaceutical Academy Email: vladimir.luzhanin_@pharminnotech.com
Natalia Eduardovna Kolomiets Kemerovo State Medical University, Siberian State Medical University Email: borkol47@mail.ru
Yaroslav Evgenievich Reshetov Siberian State Medical University Email: ferroplex_2013@yandex.ru
Andrey Kenneth Waillie St. Petersburg State Chemical and Pharmaceutical University https://orcid.org/0000-0002-4847-5924 Email: 9968639_@gmail.com
Anastasia Olegovna Weilly St. Petersburg State Chemical and Pharmaceutical University, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences https://orcid.org/0000-0003-4879-9336 Email: anastasiya.ponkratova_@yandex.ru
Roman Sergeevich Boev Visterra LLC Email: brs-0_@mail.ru
Mikhail Valerievich Belousov Siberian State Medical University, National Research Tomsk Polytechnic University Email: mvb63_@mail.ru

https://doi.org/10.14258/jcprm.20250114852

Ключевые слова: drug candidates, traditional and modern methods, in silico

Аннотация

Until the beginning of the 21st century researchers spent decades searching for new natural sources of medicines using so-called 'traditional classical' chemical, physical-chemical, in vitro and in vivo methods. The use of this method has allowed the discovery of numerous plants that have become a source of valuable medicinal preparations. However, all of them require significant financial and time investments. Therefore, scientists faced the challenge of rationalizing the process of searching for promising candidates, reducing the time and financial costs of preclinical and clinical research phases, and increasing the efficiency of the final outcome.

Increasingly popular modern method of searching for prospective plant-origin drug candidates is in silico, using on-line services and platforms, each of which individually has disadvantages. The most effective is the integration of several service databases.

This allow researchers to identify possible directions for studying the combined effects of isolated substances, thereby reducing the volume of necessary experimental studies in vitro and in vivo.

The combination of traditional methods of isolation and structure determination with modern in silico methods for determining biological activity is confirmed by literature data and our research, in which the combination identified species that are promising for further study.

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Биографии авторов

Vladimir Gennadievich Luzhanin , Perm State Pharmaceutical Academy

Candidate of Biological Sciences, Associate Professor, Rector, Head of the Department of Botany and Pharmaceutical Biology

Natalia Eduardovna Kolomiets, Kemerovo State Medical University, Siberian State Medical University

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmacy, Professor of the Department of Pharmaceutical Analysis

Yaroslav Evgenievich Reshetov, Siberian State Medical University

Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Pharmaceutical Analysis

Andrey Kenneth Waillie, St. Petersburg State Chemical and Pharmaceutical University

Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Pharmacognosy

Anastasia Olegovna Weilly , St. Petersburg State Chemical and Pharmaceutical University, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Candidate of Pharmaceutical Sciences, Junior Researcher of the Department of Pharmacognosy, Senior Researcher of the Laboratory of Cellular Mechanisms of Blood Homeostasis

Roman Sergeevich Boev , Visterra LLC

Candidate of Pharmaceutical Sciences, Director of Science

Mikhail Valerievich Belousov , Siberian State Medical University, National Research Tomsk Polytechnic University

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmaceutical Analysis

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