OPTIMAL CONDITIONS FOR CLEANING AND DRYING FUROSTANOL SAPONINS FROM TRIBULUS TERRESTRIS
UDС 615.322:542.06
Abstract
Furostanol saponins from Tribulus terrestris may be separated from ballast substances by liquid-liquid extraction with changing polarity of the extractant, depending on the dynamics of the process. Treatment with chloroform removed the maximum number of lipid-like compounds and showed minimal losses of furostanol saponins, and subsequent treatment with ethyl acetate retrieved low-polarity substances. Fourfold extraction with butanol was used to extract furostanol saponins from an aqueous solution. Optimal conditions were developed for spray drying of furostanol saponins. The greatest yield of “Dry extract Tribulus” was obtained with a solution feed rate of 80 l/h, a spray head rotation speed of 8000 rpm, and a heat carrier velocity of 2000 kg/h. Technology was developed for obtaining “Dry extract Tribulus” from Tribulus terrestris that contained at least 45% furostanol saponins. The reproducibility of the developed technology was shown with the obtaining of 5 series of substances that meet the requirements of regulatory and technical documentation on the lines of the Scientific and Technological Center for GMP Requirements the Institute of Chemistry of Plant Substances.
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Grigorova S., Kashamov B., Sredkova V., Surdjiiska S., Zlatev H. Biotechnology in Animal Husbandry, 2008, vol. 24(3-4), pp. 139–146. DOI: 10.2298/BAH0804139G.
Hammoda H., Ghazy N., Harraz F., Radwan M., El Sohly M., Abdallah I. Planta Medica, 2013, vol. 79(05), pp. 153–159. DOI: 10.1055/s-0033-1336498.
Sharifi A. M., Darabi R., Akbarloo N. Life Sciences, 2003, vol. 73(23), pp. 2963–2971. DOI: 10.1016/j.lfs.2003.04.002.
Chhatre S., Nesari T., Somani G., Kanchan D., Sathaye S. Pharmacognosy Reviews, 2014, vol. 8, pp. 45–51. DOI: 10.4103/0973-7847.125530.
Murthy A.R., Dubey S.D., Tripathi K. Ancient Science of Life, 2000, vol. 3(4), pp. 139–145.
Amin A., Lotfy M., Shafiullah M., Adeghate E. Annals of the New York Academy of Sciences, 2006. vol. 1084, pp. 391–401. DOI: 10.1196/annals.1372.005.
Yakovlev G.P., Belodubrovskaya G.A., Blinova K.F., Alekseeva G.M. Farmakognoziya. Lekarstvennoye syr'ye rastitel'nogo i zhivotnogo proiskhozhdeniya: uchebnoye posobiye. [Pharmacognosy. Medicinal raw materials of plant and animal origin: a tutorial]. St. Petersburg, 2013. 847p. (in Russ.).
Heidari M.R., Mehrabani M., Pardakhty A, Khazaeli P., Zahedi M.J., Yakhchali M. et al. Annals of the New York Academy of Sciences, 2007, vol. 1095, pp. 418–427. DOI: 10.1196/annals.1397.045.
Ojha S.K., Nandave M., Arora S., Narang N., Dinda A.K., Arya D.S. International Journal of Pharmacology, 2008, vol. 4(1), pp. 1–10.
Khristich T.N., Moseichuk Yu.Yu., Sivous O.V., Gusak V.V., Gontsaryuk D.A. Bukovinskiy meditsinskiy vesnik, 2011, vol. 15, pp. 126–129. (in Russ.).
Protich M., Tsvetkov D. et al. Akusherstvo i ginekologiya, 1983, vol. 4(12), pp. 326–329. (in Russ.).
Gorpinchenko I.I., Gurzhenko A.Yu. Zdorov'ye muzhchiny, 2008, vol. 3, pp. 89–94. (in Russ.).
Liu T., Lu X., Wu B., Chen G., Hua H.-M., Pei Y.-H. Journal of Asian Natural Products Research, 2010, vol. 12(1), pp. 30–35. DOI: 10.1080/10286020903405449.
Simeonov E., Yaneva Z., Chilev C. Rev. Chim., 2020, vol. 71(12), pp. 56–66. DOI: 10.37358/Rev.Chim.1949.
Huang J.W., Tan C.H., Jiang S.H., Zhu D.Y. Journal of Asian Natural Products Research, 2003, vol. 5(4), pp. 285–290. DOI: 10.1080/1028602031000111996.
Khaleghi S., Bakhtiari M., Asadmobini A., Esmaeili F. Journal of Evidence-Based Complementary and Alternative Medicine, 2017, vol. 22(3), pp. 407–412. DOI: 10.1177/2156587216668110.
Neychev V., Mitev V. Journal of Ethnopharmacology, 2016, vol. 179, pp. 345–355. DOI: 10.1016/j.jep.2015.12.055.
Capece M., Romeo G., Ruffo A., Romis L., Mordente S., Di Lauro G. Urologia Journal, 2017, vol. 84(2), pp. 79–82. DOI: 10.5301/uro.5000210.
Wang Y., Ohtani K., Kasai R., Yamasaki K. Phytochemistry, 1997, vol. 45(4), pp. 811–817.
Kam S.C., Do J.M., Choi J.H., Jeon B.T., Roh G.S., Hyun J.S. Journal of Sexual Medicine, 2012, vol. 9(10), pp. 2544–2551. DOI: 10.1111/j.1743-6109.2012.02889.x.
Xu Y.J., Xu T.H., Zhou H.O., Li B., Xie S.X., Si Y.S., Liu Y., Liu T.H., Xu D.M. Journal of Asian Natural Products Research, 2010, vol. 12(5), pp. 349–354. DOI: 10.1080/10286021003747458.
Wang Z.F., Wang B.B., Zhao Y., Wang F.X., Sun Y., Guo R.J., Song X.B., Xin H.L., Sun X.G. Molecules, 2016, vol. 21(4), 429. DOI: 10.3390/molecules21040429.
De Combarieu E., Fuzzati N., Lovati M., Mercalli E. Fitoterapia, 2003, vol. 74(6), pp. 583–591. DOI: 10.1016/S0367-326X(03)00152-7.
Khudenko P.E., Morokhina S.L., Popov D.M., Tereshina N.S. Farmatsiya i farmakologiya, 2015, vol. 2(9), pp. 18–23. DOI: 10.19163/2307-9266-2015-3-2(9)-18-23. (in Russ.).
Khudenko P.E., Tereshina N.S., Morokhina S.L. Farmatsiya, 2016, vol. 65(5), pp. 19–22. (in Russ.).
Wu T.S., Shi L.S., Kuo S.C. Phytochemistry, 1999, vol. 50(8), pp. 1411–1415.
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