ANTIRADICAL ACTIVITY OF WATER-ALCOHOL EXTRACTS OF RHODODENDRON ADAMSII R., GROWING IN YAKUTIA
UDC 547.19
Abstract
Classes of extractive substances of rhododendron Adams, growing in the Republic of Sakha (Yakutia), contained in an aqueous extract and extracts based on 20, 40, 70 and 95% ethyl alcohol were studied. It is shown that these are mainly phenolic compounds, tannins and flavonoids. Moreover, the maximum amount of them is contained in an extract based on 40% ethyl alcohol.
The HPLC method revealed the presence of chlorogenic, caffeic, gallic acids, rutin, quercetin and dihydroquercitin in extracts.
In model reactions with a free stable 2,2-diphenyl-1-picrylhydrazyl radical, the antiradical properties of water-alcohol solutions of Adams rhododendron were studied. The results of the DPPH test showed that the antiradical activity (ARA) is minimal for an extract based on 95% alcohol and increases from 46.7% in the case of an aqueous extract to 60.2% for a 40% aqueous alcohol extract, which is due to the peculiarity of their chemical composition. It is shown that the antiradical activity of extracts correlates well with the content of phenolic compounds in their composition (correlation coefficient 0.98).
According to the size of the ARA, water-alcohol extracts can be arranged in the following row: 40% extract > 20% extract > 70% water-alcohol extract > water extract > 95% alcohol extract.
Downloads
Metrics
References
Skurikhin I.M., Tutel'yan V.A. Khimicheskiy sostav rossiyskikh produktov pitaniya: Spravochnik. [Chemical composi-tion of Russian food products: Directory]. Moscow, 2002, 236 p. (in Russ.).
Olennikov D.N., Nikolaev M.V., Chirkova N.K. Antioxidants, 2021, vol. 10, no. 6, p. 863. DOI: 10.3390/antiox10060863.
Usov L.A., Mirovich V.M., Leventa A.I., Kichigina Ye.L. Sibirskiy meditsinskiy zhurnal, 1995, no. 3, pp. 37–40. (in Russ.).
Usov L.A., Leventa A.I., Odinets A.D. Sibirskiy meditsinskiy zhurnal, 2010, no. 5, pp. 125–128. (in Russ.).
Makarov V.Ye., Mirovich V.M., Fedoseyev A.P., Fedoseyeva G.M. Chetvertyy mezhdunarodnyy kongress molodykh uchenykh i spetsialistov «Nauki o cheloveke». [The Fourth International Congress of Young Scientists and Specialists “Human Sciences”]. Tomsk, 2003, pp. 209–210. (in Russ.).
Paisova O.I., Mirovich V.M., Fedoseyeva G.M., Makarenko S.P., Petrova I.G. Sibirskiy meditsinskiy zhurnal, 2006, no. 9, pp. 98–99. (in Russ.).
Belousov M.V., Saratikov A.S., Akhmedzhanov R.R., Berezovskaya T.P., Yusubov M.S., Dmitruk S.Ye., Ba-sova Ye.V. Rastitel'nyye resursy, 2006, vol. 42, no. 2, pp. 90–101. (in Russ.).
Belousov M.V., Basova Ye.V., Yusubov M.S., Berezovskaya T.P., Pokrovskiy L.M., Tkachev A.V. Khimiya Ras-titel'nogo Syr'ya, 2000, no. 3, pp. 45–64. (in Russ.).
Mirovich V.M., Konenkina T.A., Fedoseyeva G.M. Sibirskiy meditsinskiy zhurnal, 2008, no. 1, pp. 79–82. (in Russ.).
Rogachev A.D., Fomenko V.V., Sal’nikova O.I., Pokrovskii L.M., Salakhutdinov N.F. Chemistry of Natural Com-pounds, 2006, vol. 42, pр. 426–430.
Mirovich V.M., Fedoseyev A.P., Fedoseyeva G.M., Kibort R.V., Makarov V.Ye., Noskova L.K. Sibirskiy meditsinskiy zhurnal, 2003, vol. 40, no. 5, pp. 69–71. (in Russ.).
Morozova Yu.A., Subotyalov M.A. Rastitel'nyye resursy, 2018, no. 3(54), pp. 347–360. (in Russ.).
Karpova Ye.A., Karakulov A.V. Khimiya Rastitel'nogo Syr'ya, 2013, no. 2, pp. 119–126. DOI: 10.14258/jcprm.1302119. (in Russ.).
Kukina T.P., Yelshin I.A., Sal'nikova O.I., Kolosov P.V., Sandag TS., Karakay D.A., Bondareva M.A., Nefedov A.A., Chirkova V.Yu., Sharlayeva Ye.A., Belen'kaya S.V., Shcherbakov D.N. Khimiya Rastitel'nogo Syr'ya, 2022, no. 4, pp.153–162. DOI: 10.14258/jcprm.20220411584. (in Russ.).
Zhavoronkova M.Ye., Aleksandrova M.S., Fursa N.S. Vestnik Permskoy gos. farmats. akademii, 2010, no. 7, pp. 72–73. (in Russ.).
Strusovskaya O.G. Nauchnyye vedomosti. Seriya meditsina. Farmatsiya, 2012, vol. 16 (135), no. 19, pp. 128–131. (in Russ.).
Razaronova K.N., Zhokhova Ye.V. Khimiya Rastitel'nogo Syr'ya, 2011, no. 4, pp. 187–192. (in Russ.).
Kuznetsova I.V. Khimiya Rastitel'nogo Syr'ya, 2015, no. 4, pp. 57–61. (in Russ.).
Zaprometov M.N. Osnovy biokhimii fenol'nykh soyedineniy. [Fundamentals of biochemistry of phenolic compounds]. Moscow, 1974, 214 p. (in Russ.).
Molyneux P. Songklanakarin J. Sci.Technol., 2004, vol. 26, no. 2, pp. 211–219.
Zhavoronkova M.Ye., Belousov M.V., Fursa N.S. Vestnik Ural'skoy meditsinskoy akademicheskoy nauki, 2011, no. 3/1, p. 58. (in Russ.).
Copyright (c) 2023 chemistry of plant raw material
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.
