EVALUATION OF ANTIOXIDANT ACTIVITY OF COMPLEXES OF DIHYDROQUERCETIN WITH BIOGENIC METALS IONS

  • Елена (Elena) Владимировна (Vladimirovna) Столповская (Stolpovskaia) Federal Research Budget Institution, A.E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Favorsky St., 1, Irkutsk, 664033 (Russia) Email: stel@irioch.irk.ru
  • Наталья (Natal'ia) Николаевна (Nikolaevna) Трофимова (Trofimova) Federal Research Budget Institution, A.E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Favorsky St., 1, Irkutsk, 664033 (Russia) Email: natrof@irioch.irk.ru
  • Василий (Vasilii) Анатольевич (Anatol'evich) Бабкин (Babkin) Federal Research Budget Institution, A.E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Favorsky St., 1, Irkutsk, 664033 (Russia) Email: babkin@irioch.irk.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.2016041402
Keywords: dihydroquercetin, complex compounds, antioxidant activity, malondialdehyde, diene and triene conjugates, catalase

Abstract

The antioxidant activity of complexes of dihydroquercetin (DHQ) with ions Zn2+, Cu2+ and Ca2+ have been investigated in experiments in vitro with blood plasma of healthy donors. The state of the lipid peroxidation (LPO) in blood plasma have been evaluated on the content of malondialdehyde (MDA), diene (DC) and triene (TC) conjugates. The impact of the complexes and DHQ on the enzyme catalase activity in blood plasma have been determined. It is found that complex of DHQ with zinc ion reduces the content of MDA in blood plasma of 14,9% compared with the control. This exceeds twice the significant for DHQ (7,5%). The corresponding figures for complexes of DHQ with ions of copper (II) and calcium are amount to 11,2 and 3,7%. Effect of complexes to decrease of DC and TC in blood plasma compared with control is comparable with the corresponding values for DHQ. Complex of DHQ with zinc ion increases catalase activity by 1,5% compared to DHQ. Complexes of DHQ with ions copper (II) and calcium increases catalase activity by no more than DHQ.

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Author Biographies

Елена (Elena) Владимировна (Vladimirovna) Столповская (Stolpovskaia), Federal Research Budget Institution, A.E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Favorsky St., 1, Irkutsk, 664033 (Russia)
candidate of chemical science, Associate Researcher, Laboratory of Wood Chemistry
Наталья (Natal'ia) Николаевна (Nikolaevna) Трофимова (Trofimova), Federal Research Budget Institution, A.E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Favorsky St., 1, Irkutsk, 664033 (Russia)
candidate of chemical science, senior researcher, Laboratory of Wood Chemistry
Василий (Vasilii) Анатольевич (Anatol'evich) Бабкин (Babkin), Federal Research Budget Institution, A.E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Favorsky St., 1, Irkutsk, 664033 (Russia)
Doctor of Chemistry, Professor, Head of the Laboratory of Wood Chemistry

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Published
2016-10-19
How to Cite
1. Столповская (Stolpovskaia)Е. (Elena) В. (Vladimirovna), Трофимова (Trofimova)Н. (Natal’ia) Н. (Nikolaevna), Бабкин (Babkin)В. (Vasilii) А. (Anatol’evich) EVALUATION OF ANTIOXIDANT ACTIVITY OF COMPLEXES OF DIHYDROQUERCETIN WITH BIOGENIC METALS IONS // chemistry of plant raw material, 2016. № 4. P. 65-70. URL: http://journal.asu.ru/cw/article/view/1402.
Issue
No 4 (2016)
Section
Low-molecular weight compounds

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