DETERMINATION OF ANTIFUNGAL ACTIVITY OF POPLAR BUDS AND PROPOLIS AGAINST COVID-19 STRAINS OF POSTCOID INFECTIONS
UDC 615.322:615.076.7:615.017
Abstract
The new coronavirus infection is currently still an important problem for humanity as well as the global medical community. The COVID-19 virus is dangerous because it causes direct damage to the epithelium of the respiratory tract, thereby contributing to the penetration of bacteria and fungi into the tissues of the body. Invasive mycoses are a serious complication and cause a high percentage of deaths in hospitalized patients. The main strains of coinfections in COVID-19 are: Aspergillus, Mucorales and Candida. The issue of treatment and the possibility of prevention of secondary fungal infections in coronavirus infection is particularly acute. The aim of the work was to determine the antifungal activity of poplar (Populus L.) buds and propolis with antimicrobial activity against fungal strains isolated from patients with a new coronavirus infection. The paper reflects the results of the study of antifungal activity of the investigated samples of extracts of Populus nigra L. and Populus rubrinervis Hort. Alb. buds (70 and 96% ethyl alcohol) against clinical strains of Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Scopulariopsis brevicaulis, Mucor spp. Propolis tincture and alcoholic solution of the reference sample (RS) of pinostrobin were the comparison preparations. The greatest activity of extracts from Populus rubrinervis Hort. Alb. buds against Aspergillus fumigatus (the content of active substances in 96% ethyl alcohol extraction – 0.0022%), Aspergillus flavus (70% ethyl alcohol extraction – 0.0019%), Aspergillus niger (70% ethyl alcohol extraction – 0.0019%), Scopulariopsis brevicaulis (70% ethyl alcohol extraction – 0.0009%). Propolis tincture showed the lowest fungicidal activity, has activity against A. niger and Scopulariopsis brevicaulis strains. The comparison preparation – alcoholic solution of RS pinostrobin showed antifungal activity against A. niger strain. Against Mucor spp. the tested extracts of poplar buds and comparison preparations did not show any pronounced fungicidal activity. The presence of fungicidal activity against strains of postcoid fungi of extracts of poplar bud extracts is presumably associated with the presence of the sum of phenolic compounds: flavonoids and phenylpropanoids.
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