OLIGOSACCHARIDE ESTERS AND XANTHONES FROM ROOTS OF POLYGALA HYBRIDA AND POLYGALA SIBIRICA (POLYGALACEAE)

UDC 582.755.2+547.586.5+547.815.1

  • Daniil Nikolaevich Olennikov Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Science http://orcid.org/0000-0001-8194-1061 Email: olennikovdn@mail.ru
  • Nina Igorevna Kashchenko Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Science Email: ninkk@mail.ru
  • Nadezhda Konstantinovna Chirikova North-Eastern Federal University Email: hofnung@mail.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20240314210
Keywords: Polygala hybrida, Polygala sibirica, Polygalaceae, oligosaccharide esters, xanthones, HPLC

Abstract

Genus Polygala Tourn. ex L. is represented in Siberia by three species including two poorly understood species, P. hybrida DC. (syn. P. comosa subsp. comosa, P. comosa var. hybrida (DC.) Petelin) and P. sibirica L. which roots are used in Eastern medicine. Chromatographic separation of P. hydrida roots components led to isolation of 21 substances identified by UV, NMR spectroscopy and mass spectrometry as xanthone glycosides (lancerin, polygalaxanthones III, VII, XI, sibiricaxanthone B, 7-methoxymangiferin) and aglycone (6-hydroxy-1,2,3,7-tetramethoxyxanthone) and oligosaccharide esters (sibericose A4, A5, A6, 6,3′-di-O-sinapoyl sucrose, 6-O-sinapoyl-3′-O-feruloyl sucrose, tenuifoliside C, tenuifolioses A, B, D, H, I, J). Two new natural compounds were isolated ana described as disubstituted hydroxycinnamoyl esters of sucrose, 4-O-sinapoyl-3′-O-3,4,5-trimethoxycinnamoyl sucrose (isotenuifoliside C1) and 4-O-3,4,5-trimethoxycinnamoyl-3′-O-sinapoyl sucrose (isotenuifoliside C2). Application of the liquid chromatography-mass spectrometry revealed the presence of 24 components in P. sibirica roots and 17 of them for the first time for the species. Quantitative analysis indicated a high content of oligosaccharide esters and xanthones in the roots of P. hydrida (56.19 and 11.64 mg/g, respectively) and P. sibirica (64.82 and 9.72 mg/g, respectively) indicating the prospects for the further reseach of two studied Polygala species.

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Author Biographies

Daniil Nikolaevich Olennikov , Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Science

Doctor of Pharmaceutical Sciences, Head of the Laboratory of Medical and Biological Research

Nina Igorevna Kashchenko , Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Science

Candidate of Pharmaceutical Sciences, Senior Researcher of the Laboratory of Medical and Biological Research

Nadezhda Konstantinovna Chirikova , North-Eastern Federal University

Doctor of Pharmaceutical Sciences, Professor of the Biological Department of the Institute of Natural Sciences

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Published
2024-09-28
How to Cite
1. Olennikov D. N., Kashchenko N. I., Chirikova N. K. OLIGOSACCHARIDE ESTERS AND XANTHONES FROM ROOTS OF POLYGALA HYBRIDA AND POLYGALA SIBIRICA (POLYGALACEAE) // chemistry of plant raw material, 2024. № 3. P. 150-160. URL: http://journal.asu.ru/cw/article/view/14210.
Issue
No 3 (2024)
Section
Low-molecular weight compounds

Copyright (c) 2024 chemistry of plant raw material

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