BIOLOGICALLY ACTIVE COMPOUNDS BASED ON MODIFIED XANTHAN GUM

  • Olij Ravshanovich Akhmedov Institute of Bioorganic Chemistry of the Uzbek Academy of Sciences Email: oliy86@bk.ru
  • Honsuluv Abduvohidovna Sohibnazarova Institute of microbiology of the Uzbek Academy of Scie Email: sumbul_nazar@mail.ru
  • Shavkat Abduganievich Shomurotov Institute of Bioorganic Chemistry of the Uzbek Academy of Sciences Email: shsha@mail.ru
Keywords: xanthan gum, periodate oxidation, dialdehyde derivatives, guanidine, microbiological examination, antibacterial effect

Abstract

We carried out chemical modification of the natural biopolymer (xanthan gum) with sodium periodate. By varying the concentration of the oxidizing agent, dialdehydes of xanthan gum were obtained with degree of oxidation 16,0–44,0 mol%. New soluble nitrogen compounds were synthesized by reacting obtained dialdehyde polysaccharide derivatives with guanidine. Structure and composition of the prepared compounds were investigated by IR spectroscopy and elemental analysis for nitrogen content. We calculated amount of guanidine and degree of substitution in the synthesized products, which amounted 31,0–85,0 mol%  and 10,5–25,5% respectively.

Biological activity of the compounds in conditions in vitro was studied against pathogenic microorganisms (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella) at a concentration of 50 mg / ml. Research results revealed that the increase in the degree of substitution and the amount of guanidine in the polysaccharide lead to increased antibacterial action of the agents. Obtained water-soluble guanidine derivatives containing xanthan gum may be used as antibacterial agents for oral and external applications.

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Author Biographies

Олий (Olij) Равшанович (Ravshanovich) Ахмедов (Akhmedov), Institute of Bioorganic Chemistry of the Uzbek Academy of Sciences
младший научный сотрудник лаборатории «Химия полисахаридов»
Хонсулув (Honsuluv) Абдувохидовна (Abduvohidovna) Сохибназарова (Sohibnazarova), Institute of microbiology of the Uzbek Academy of Scie
младший научный сотрудник лаборатории «Генетика молочнокислых бактерий»
Шавкат (Shavkat) Абдуганиевич (Abduganievich) Шомуротов (Shomurotov), Institute of Bioorganic Chemistry of the Uzbek Academy of Sciences
старший научный сотрудник лаборатории «Химия полисахаридов», кандидат химических наук

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Published
2017-01-31
How to Cite
1. Ахмедов (Akhmedov)О. (Olij) Р. (Ravshanovich), Сохибназарова (Sohibnazarova)Х. (Honsuluv) А. (Abduvohidovna), Шомуротов (Shomurotov)Ш. (Shavkat) А. (Abduganievich) BIOLOGICALLY ACTIVE COMPOUNDS BASED ON MODIFIED XANTHAN GUM // chemistry of plant raw material, 2017. № 3. P. 227-231. URL: http://journal.asu.ru/cw/article/view/1729.
Section
Short reports