BIOLOGICALLY ACTIVE COMPOUNDS BASED ON MODIFIED XANTHAN GUM
Abstract
We carried out chemical modification of the natural biopolymer (xanthan gum) with sodium periodate. By varying the concentration of the oxidizing agent, dialdehydes of xanthan gum were obtained with degree of oxidation 16,0–44,0 mol%. New soluble nitrogen compounds were synthesized by reacting obtained dialdehyde polysaccharide derivatives with guanidine. Structure and composition of the prepared compounds were investigated by IR spectroscopy and elemental analysis for nitrogen content. We calculated amount of guanidine and degree of substitution in the synthesized products, which amounted 31,0–85,0 mol% and 10,5–25,5% respectively.
Biological activity of the compounds in conditions in vitro was studied against pathogenic microorganisms (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella) at a concentration of 50 mg / ml. Research results revealed that the increase in the degree of substitution and the amount of guanidine in the polysaccharide lead to increased antibacterial action of the agents. Obtained water-soluble guanidine derivatives containing xanthan gum may be used as antibacterial agents for oral and external applications.Downloads
Metrics
References
Gensh K.V., Bazarnova N.G. Khimiia rastitel,nogo syr,ia, 2006, no. 2, pp. 25–28. (in Russ.).
Yan J., Abdelgawad A., El-Naggar M., Rojas O. Carbohydrate Polymers, 2016, vol. 147, pp. 500–508.
Virnik A.D., Khomiakov K.P., Skokova I.F. Uspekhi khimii, 1975, vol. XLIV, pp. 1281–1307. (in Russ.).
Khitin i khitozan. Poluchenie, svoistva i primenenie. [Chitin and Chitosan. Preparation, Properties and Applications]. Moscow, 2002, 361 p. (in Russ.).
Garcia-Ochoa F., Santos V., Casas J., Gomez A. Biotechnology Advances, 2000, vol. 18, pp. 549–579.
Guo J., Ge L., Li X., Mu Ch., Li D. Food Hydrocolloids, 2014, vol. 39, pp. 243–250.
Liu K., Xu Y., Lin X., Chen L., Huang L., Cao Sh., Li J. Carbohydrate Polymers, 2014, vol. 110, pp. 382–387.
Ding W., Zhao P., Li R. Carbohydrate Polymers, 2011, vol. 83, pp. 802–807.
Patent 2435785 (RU). 2011. (in Russ.).
Sahraro M., Yeganeh H., Sorayya M. Materials Science and Engineering C, 2016, vol. 59, pp. 1025–1037.
Аfinogenov G.E., Panarin E.F. Аntimikrobnye polimery. [Antimicrobial polymers]. St. Petersburg, 1993, 14 p. (in Russ.).
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.