EFFECT OF MICROWAVE IRRADIATION ON ARABINOGALACTAN AND ITS INTERACTION WITH BETULIN DIACETATE
Abstract
Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this work, influence of microwave (MW) irradiation on the properties of AG and BDA and their interaction in the aqueous suspension with formation of a water-soluble supramolecular complex was studied. It is shown that the MW heating of AG under hard conditions can lead to degradation of the biopolymer. The use of MW heating allowed significantly reducing the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under MW irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under MW irradiation similar to that formed by conventional heating. BDA-AG complex was isolated from a MW heated solution as a thin film, which may be a promising material for pharmaceutical applications.
Downloads
Metrics
References
Kappe C.O. Angewandte Chemie International Edition, 2004, vol. 43, no. 46, pp. 6250–6284.
Alexandre F.-R., Domon L., Frère S., Testard A., Thièry V., Besson T. Molecular Diversity, 2003, vol. 7, no. 2, pp. 273–280.
Doehler D., Peterlik H., Binder W.H. Polymer, 2015, vol. 69, pp. 264–273.
De la Hoz A., Loupy A. Microwaves in Organic Synthesis: Third Edition. Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2013, vol. 2, 1251 p.
Shakhtshneider T.P., Kuznetsova S.A., Mikhailenko M.A., Zamai A.S., Malyar Yu.N., Zamai T.N., Boldyrev V.V. Chemistry of Natural Compounds, 2013, vol. 49, pp. 470–474.
Patent 2013117137 (WO). 15.08.2013.
Shakhtshneider T.P., Mikhailenko M.A., Kuznetsova S.A., Malyar Yu.N., Zamai A.S. Boldyrev V.V. Natural Product Research, 2016, vol. 30, no. 12, pp. 1382–1387.
Patent 2324700 (RU). 20.05.2008 (in Russ.).
Patent 2273646 (RU). 10.04.2006 (in Russ.).
Dushkin A.V., Meteleva E.S., Tolstikova T.G., Tolstikov G.A., Polyakov N.E., Neverova N.A., Medvedeva E.N., Babkin V.A. Russian Chemical Bulletin, 2008, vol. 57, no. 6, pp. 1299–1307.
Grassie N., Scott G. Polymer Degradation and Stabilisation. Cambridge University Press, 1985, 222 p.
Butyagin P. Journal of Materials Synthesis and Processing, 2000, vol. 8, no. 3, pp. 205–211.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.
