THE STUDY OF PHYSICO-TECHNOLOGICAL FACTORS’ INFLUENCE ON THE OUTPUT OF LIPOPHILIC SUB-STANCES FROM MEDICINAL PLANT MATERIALS

  • Ekaterina Aleksandrovna Degtyareva National University of Pharmacy Email: kate.deg.88@gmail.com
  • Liliya Ivanovna Vyshnevska National University of Pharmacy Email: liliiavyshnevska@gmail.com
  • Svetlana Vasil'yevna Garnaya National University of Pharmacy Email: garnaya57@gmail.com
  • Ekaterina Aleksandrovna Kalko National University of Pharmacy Email: ketrin27kalko@gmail.com
Keywords: medicinal plant materials, pumpkin, lipophilic substances, extraction

Abstract

Currently, the lipophilic fractions of well-known medicinal plants are still understudied despite of contains of unique groups of BAS (chlorophylls, carotenoids, tocopherols, sterols, unsaturated fatty acids, phospholipids, etc.), what is the actual task of modern pharmaceutical science.

The aim of our work was to perform experimental studies for the choice of optimal conditions of the extraction of lipophilic compounds from the meal of pumpkin pulp.

Extraction of lipophilic substances from the meal of pumpkin pulp was carried out in laboratory conditions in the Soxhlet apparatus by the method of circulation extraction. The weight loss on drying, the content of extractive lipophilic substances and the amount of carotenoids (in terms of β-carotene) were determined by compendial procedures.

According to the results of the experimental work, the optimum humidity (not more than 7%) and drying temperature (+ 60 °C) of pumpkin pulp meal containing carotenoids were established. The obtained data are necessary for the development of technology of lipophilic pumpkin extract.

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Author Biographies

Ekaterina Aleksandrovna Degtyareva, National University of Pharmacy

старший преподаватель, кандидат фармацевтических наук

Liliya Ivanovna Vyshnevska, National University of Pharmacy

профессор кафедры аптечной технологии лекарств, доктор фармацевтических наук

Svetlana Vasil'yevna Garnaya, National University of Pharmacy

профессор кафедры качества, стандартизации и сертификации лекарств, доктор фармацевтических наук

Ekaterina Aleksandrovna Kalko, National University of Pharmacy

ассистент кафедры клинической фармации, кандидат фармацевтических наук

References

Manal K. Abdel-Rahman, World Journal of Chemistry, 2006, vol. 1, no. 1, pр. 33–40.

Malgwi I.S., Olorunshola K.V., Hamman W.O., Eze E.D., Onaadepo O. Annals of Experimental Biology, 2014, vol. 2, no. 1, pр. 11–16.

John C., Leffingwell , Alford E. D., Leffingwel D. Leffingwell Reports.Georgia, 2015, vol. 7, no. 1, pр. 1–14.

Adnan M., Gul S., Batool S., Fatima B., Rehman Ali, Yaqoob S., Shabir H., Yousaf T., Mussarat S., Nawab A., Niaz Khan S., Rahman H., Abdul Aziz M. The Journal of Phytopharmacology, 2017, vol. 6, no. 2, pр. 133–139.

Demeshko O.V., Kovalʹov S.V., Myhalʹ A.V. Farmatsevtychnyy chasopy, 2012, no. 3, pp. 35–38. DOI: https://doi.org/10.11603/2312-0967.2012.3.2630. (in Ukrainian).

Karagulov KH.G., Stepanova E.F., Yevseyeva S.B. Farmatsiya i farmakologiya, 2013, no. 1, pp. 56–58. (in Russ.).

Kuregyan A.G., Pechinskiy S.V., Zilfikarov I.N. Razrabotka i registratsiya lekarstvennykh sredstv, 2014, no. 1(6), pp. 54–63. (in Russ.).

Bakan E., Akbulut Z. T., İnanç A.L. Academic Food Journal, 2014, vol. 12, no. 2, pp. 61–68.

Omayma A. Eldahshan, Abdel Nasser B. Singab. Journal of Pharmacognosy and Phytochemistry, 2013, vol. 2, no. 1, pp. 225–233.

Andrew J.Y., Gordon L.L. Antioxidants, 2018, vol. 7, pp. 1–4. DOI: 10.3390/antiox7020028.

Nawirska-Olszańska A., Kita A., Biesiada A., Sokół-Łętowska A., Kucharska A.Z. Food Chem., 2013, vol. 139, no. 1. pр. 155–161. DOI: 10.1016/j.foodchem.2013.02.009.

Hidalgo F.J., León M.M., Zamora R. J. Agr Food Chem., 2007, vol. 55, pp. 4436–4442. DOI: 10.1021/jf070119s.

Doert M., Jaworska K., Moersel J.-T., Kroh L. Eur Food Res Technol., 2012, vol. 235, pp. 915–928. DOI: https://doi.org/10.1007/s00217-012-1815-7.

Kaanan KH.M., Kryvoruchko E.V., Khalaf H., Murtada M., Yassyn A. Zhurnal orhanichnoyi ta farmatsevtychnoyi khimiyi, 2008, vol. 6, issue 2, pp. 71–75. (in Russ.).

Mogensen K.M. Practical Gastroenterology, 2017, vol. 164, pp. 37–44.

Calder P.C. JPEN J Parenter Enteral Nutr., 2015, vol. 39, pp. 18–39. DOI: 10.1177/0148607115595980.

Contarini G., Povolo M. International Journal of Molecular Sciences, 2013, vol. 14, pp. 2808–2831. DOI: 10.3390%2Fijms14022808.

Martinson Ye.A., Kropachev D.A., Zlobin A.A., Zhukov N.A. Biotekhnologiya: sostoyaniye i perspektivy razvitiya : ma-terialy 4-go moskovskogo mezhdunarodnogo kongressa. [Biotechnology: state and development prospects: materials of the 4th Moscow International Congress]. Moscow, 2007, pp. 219. (in Russ.).

Budayeva V.V., Yakimov D.Y. Polzunovskiy vestnik, 2007, no. 3, pp. 15–24. (in Russ.).

Hladukh YE.V., Sayko I.V., Lyapunova O.A., Mansʹkyy O.A. Promyslove vyrobnytstvo ekstraktsiynykh likarsʹkykh form. Metodychni rekomendatsiyi do laboratornykh zanyat. [Industrial production of extraction dosage forms. Methodical recommendations for laboratory work]. Kharkiv, 2014, 71 p. (in Ukrainian).

Simsek M., Sumnu G., Sahin S. Separ. Sci. Technol., 2012, vol. 47, no. 8, pр. 1248–1254. DOI: 10.1080/01496395.2011.644616.

Harna S.V., Vyetrov P.P., Heorhiyants V.A. Aktualʹni pytannya farmatsevtychnoyi i medychnoyi nauky ta praktyky. [Topical issues in pharmaceutical and medical science and practice]. 2012, no. 1, pp. 54–57. (in Ukrainian).

Rodr´ıguez-Rojo S., Visentin A., Maestri D., Cocero M. J. Food. Eng., 2012, vol. 109, no. 1, pр. 98–103. DOI: 10.1016/j.jfoodeng.2011.09.029

Dehtyarʹova K.O., Horlacheva V.I. Zbirnyk naukovykh pratsʹ spivrobitnykiv NMAPO im. P. L. Shupyka. [Collection of scientific works of NMAPE employees P.L. Shupik]. Kiev, 2016, issue 26, pp. 333–338. (in Ukrainian).

Harna S.V., Vyetrov P.P., Rusynov O.I., Heorhiyants V.A., Vershkova I.V. Zaporozhskyy medytsynskyy zhurnal, 2010, no. 4, pp. 71–73. (in Ukrainian).

Gosudarstvennaya farmakopeya Ukrainy. [The State Pharmacopoeia of Ukraine]. 2nd ed., Kharkiv, 2015, vol. 1, 1128 p. (in Russ.).

Degtyareva Ye.A., Grud'ko V.O., Vishnevskaya L.I., Bisaga Ye.I. Aktual'nyye voprosy farmatsevticheskoy i medi-tsinskoy nauki i praktiki, 2015, no. 2, pp. 45–48. (in Russ.).

Published
2019-04-07
How to Cite
1. Degtyareva E. A., Vyshnevska L. I., Garnaya S. V., Kalko E. A. THE STUDY OF PHYSICO-TECHNOLOGICAL FACTORS’ INFLUENCE ON THE OUTPUT OF LIPOPHILIC SUB-STANCES FROM MEDICINAL PLANT MATERIALS // chemistry of plant raw material, 2019. № 3. P. 299-305. URL: http://journal.asu.ru/cw/article/view/5098.
Section
Technology