STANDARDIZATION OF DRY EXTRACT OF ZIZIPHUS JUJUBA MILL. FRUITS
UDC 615.072
Abstract
Ziziphus jujuba Mill. (jujube) fruits have been used in folk medicine for a long time as a drug to treat arterial hypertension. Scientists in A. Sultanov Uzbek Research Institute for Chemistry and Pharmaceutics have developed a technology that permits to obtain dry extract named «Unabin» with hypotensive effect.
The aim of research: to develop quality control and standardization methods for dry extract of jujube fruits.
Jujube dry extract was described as a brown powder with sweet taste and specific odor. Water content in samples was 3.1–4.8% (measured according to State Pharmacopoeia of Russian Federation XI).
We studied 5 series of dry extract. It was revealed that 1 g of dry extract contains 106 of aerobic bacteria, 103 of yeasts and mold fungi altogether, 102 of enterobacteria and other gram-negative bacteria in average. Esherichia coli, Salmonella, Pseudomоnаs aeruginosa и Staphylococcus aureus were not detected. Therefore, the studied pharmaceutical meets the standard of microbiological cleanliness.
The optimal content of the following substances was determined: flavonoids (in rutin equivalent; no less than 0.2%), polysaccharides (no less than 1.8%), organic acids (in malic acid equivalent; no less than 1.5%), tanning agents (in tannin equivalent; no less than 5.0%). The proposed permissible content of heavy metals (Pb, Cd) is 0.01% or less.
The shelf life of jujube dry extract is 2 years and more (assessed in natural conditions according to Branch Standard 42-2-70). The project of Pharmacopoeia article was prepared on the basis of conducted reseach.
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