STRESS-PROTECTIVE EFFECT OF AQUEOUS INFUSION OF FERMENTED LEAVES CHAMAENERION AN-GUSTIFOLIUM (L.) SCOP.
UDC 615
Abstract
The stress-protective effect of an aqueous infusion of fermented leaves of flowering plants of Сhamaenerion angustifolium (L.) Scop., (Onagraceae) collected in the middle taiga zone of the European North-East of Russia (near Syktyvkar), in experiments on white laboratory mice under acute stress has been studied. As a model of acute stress, the hanging of animals by the neck fold for 19 hours was used. Water infusion (1 : 20) was administered to each animal 0.5 and 1.0 ml for five days per os. It was found that the prophylactic administration of water infusion of fermented leaves in doses of 0.5 and 1.0 ml lead to normalizing effect on the mass of internal organs and peripheral blood parameters that have sharp pathological deviations under stress. The content of ascorbic acid and cholesterol in the adrenal glands and malonic dialdehyde in the liver of animals receiving infusion, approached the corresponding values in intact animals, which indicates the protective and antioxidant effects. With the introduction of sodium nitroprusside (25 mg/kg) and ethanol (25% solution, 9g/kg) a pronounced antihypoxic and antitoxic effects were found, which are typical for such well-known adaptogenic plants as ginseng and eleutherococcus. Due to data obtained, the raw material of fermented leaves of Сhamaenerion angustifolium could be considered as adaptogenic remedy that increases the overall non-specific resistance of the body and recommended not only as a tonic tea drink, but also for wider use in functional nutrition and medicine for the prevention and treatment of stress-induced and age-dependent diseases.
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