EFFECT OF DIHYDROQUERCETIN ON HYPERCHOLESTERINEMIA

UDC 577.19

  • Nikolay Petrovich Sudakov Irkutsk Scientific Centre of Surgery and Traumatology; Limnological Institute SB RAS Email: npsudakov@gmail.com
  • Tatiana Pavlovna Popkova Irkutsk Scientific Centre of Surgery and Traumatology Email: ptanp@mail.ru
  • Evgeniya Aleksandrovna Lozovskaya Irkutsk Scientific Centre of Surgery and Traumatology Email: molodegny31@mail.ru
  • Sergey Borisovich Nikiforov Irkutsk Scientific Centre of Surgery and Traumatology Email: telomer@mail.ru
  • Igor Viktorovich Klimenkov Irkutsk Scientific Centre of Surgery and Traumatology; Limnological Institute SB RAS Email: iklimen@mail.ru
  • Svetlana Dmitriyevna Yezhikeyeva Irkutsk State Regionary Hospital Email: ezhikeev@mail.ru
  • Marina Nikolayevna Ten Irkutsk State Regionary Hospital Email: ezhikeev@mail.ru
  • Aleksey Aleksandrovich Levchuk A.E. Favorsky Irkutsk Institute of Chemistry SB RAS Email: on_sam@mail.ru
  • Vasiliy Anatol'yevich Babkin A.E. Favorsky Irkutsk Institute of Chemistry SB RAS Email: babkin@irioch.irk.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.2020047767
Keywords: cholesterol, atherosclerosis, experimental hypercholesterolemia, dihydroquercetin, bioflavonoids

Abstract

The article is devoted to the study of the natural flavonoid dihydroquercetin (0.0125 g per 1 kg of animal weight in daily diet) effect on the development of experimental hypercholesterolemia in rabbits “Chinchilla”. Dihydroquercetin was obtained by extraction with ethyl acetate from crushed Siberian larch (Larix sibirica Ledeb., 1833) wood chips with several cycles of subsequent recrystallization from water (purity 90–92%). Hypercholesterolemia was induced by an atherogenic diet: 0.35 g of cholesterol in the diet per 1 kg of animal weight. The duration of the experiment was two months. It was shown that the introduction of dihydroquercetin into the daily diet of rabbits with alimentary hypercholesterolemia does not significantly affect the level of total cholesterol, as well as the concentration of its atherogenic fractions of LDL and VLDL in the blood. Nevertheless, it was found that, in comparison with the model of hypercholesterolemia, this natural compound contributes to the maintenance of an increased concentration of HDL cholesterol, which has an antiatherogenic effect. Accordingly, this reduces the value of the blood atherogenic coefficient, which reflects the degree of risk of atherosclerosis. In general, the data obtained predetermines the need for further research using various approaches to modeling hypercholesterolemia and atherosclerosis in experimental animals.

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Author Biographies

Nikolay Petrovich Sudakov, Irkutsk Scientific Centre of Surgery and Traumatology; Limnological Institute SB RAS

кандидат биологических наук, доцент, старший научный сотрудник

Tatiana Pavlovna Popkova, Irkutsk Scientific Centre of Surgery and Traumatology

младший научный сотрудник

Evgeniya Aleksandrovna Lozovskaya, Irkutsk Scientific Centre of Surgery and Traumatology

кандидат ветеринарных наук, научный сотрудник

Sergey Borisovich Nikiforov, Irkutsk Scientific Centre of Surgery and Traumatology

доктор медицинских наук, заведующий научным отделом экспериментальной хирургии с виварием

Igor Viktorovich Klimenkov, Irkutsk Scientific Centre of Surgery and Traumatology; Limnological Institute SB RAS

доктор биологических наук, доцент, ведущий научный сотрудник

Svetlana Dmitriyevna Yezhikeyeva, Irkutsk State Regionary Hospital

врач КДЛ

Marina Nikolayevna Ten, Irkutsk State Regionary Hospital

врач КДЛ

Aleksey Aleksandrovich Levchuk, A.E. Favorsky Irkutsk Institute of Chemistry SB RAS

кандидат технических наук, научный сотрудник

Vasiliy Anatol'yevich Babkin, A.E. Favorsky Irkutsk Institute of Chemistry SB RAS

доктор химических наук, заведующий лабораторией химии древесины

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Published
2020-12-21
How to Cite
1. Sudakov N. P., Popkova T. P., Lozovskaya E. A., Nikiforov S. B., Klimenkov I. V., Yezhikeyeva S. D., Ten M. N., Levchuk A. A., Babkin V. A. EFFECT OF DIHYDROQUERCETIN ON HYPERCHOLESTERINEMIA // chemistry of plant raw material, 2020. № 4. P. 281-288. URL: http://journal.asu.ru/cw/article/view/7767.
Issue
No 4 (2020)
Section
Application

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