INVESTIGATION OF INCLUSION COMPLEXES OF SOME ANTHOCYANINS WITH HYDROXYPROPYL-Β-CYCLODEXTRIN
Abstract
In the present paper spectrophotometric (including electronic spectra differences) method has been used for investigation of complex formation between anthocyanins with hydroxypropyl-β-cyclodextrin (HPbCD). For the system analysis also molecular mechanics method (ММ+) has been explored. It enables to theoretically predict as well as to prove experimentally the possibility of complex formation of flavylium form by inserting of B ring into cyclodextrin cavity. Stability of complexes was shown to depend upon steric factors – the volume of glycosyl moiety in 3 position of the anthocyanin backbone; the change of hybridization type of carbon atom 2 (sp2 →sp3) decrease steric hindrance; the latter is the reason of the most stable complexes for hemiacetal form leading to solution bleaching. The slow anthocyanin forms equilibration is a property of hemiacetal – chalkone transitions depending not upon HPbCD addition, the participation of the latter in complexation is negligible.
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