PHENOLIC COMPOUNDS FROM AERIAL PARTS OF GERANIUM CHARLESII (AITCH. HEMSL.) VVED.
Abstract
The phenolic compounds from the aerial part (stems, leaves and flowers) of Geranium charlesii (Aitch. & Hemsl.) Vved. (Geranium of Charles from family Geraniaceae) growing in Uzbekistan were studied. For the first time from this type of geranium by column chromatography from ethyl acetate and n-butanol fraction of 70% ethanol extract sequentially isolated phenolic compounds. At the separation of the ethylacetate fraction by column chromatography identified five individual compounds, including gallic acid (1) methyl gallate (2), kaempferol (3), quercetin (4) and isorhamnetin (5) and from n-butanol fractions - isorhamnetin 3-O-β-D-glucopyranoside (6) isoquercitrin (7), isorhamnetin-3-O-vicianoside (8).
According to our phytochemical studies first time showed that aerial part of the plant G. charlesii is a source of biologically active phenolic compounds 1-8. It should be noted that compounds 1-4 and 7 have been previously isolated from Geranium saxatile and Geranium tuberosum L. subsp. tuberosum, and 5, 6, 8, were first time isolated from Geranium charlesii in whole plants from the genus Geranium. The predominant by content of this species Geranium are gallic acid (1) and isorhamnetin-3-O-vicianoside (8). The compounds were identified on the basis of the physical and chemical methods, IR, UV, NMR spectroscopy and mass-spectrometry.Downloads
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