COMPARATIVE STUDY OF FLAVONOIDS AND COUMARINS IN MEDICINAL PREPARATIONS OF CHAMOMILLA RECUTITA (L.) RAUSCHERT
Abstract
Flowers of Chamomilla recutita (L.) Rauschert are used in medicine as anti-inflammatory, spasmolytic and antiseptic drug. Main pharmacological effects are associated with flavonoids and coumarins. Development of new preparations from Chamomilla is possible on the base of lypophylic extra gents application such as plant oils..
Flavonoids and coumarins composition of oil extract of Chamomilla flowers, infusion and tincture was analyzed by UV-spectroscopy and UV-HPLC. Umbelliferone, herniarin, apigenin and quercetin were founded in all preparations, while quercetin was not found in oil extract only. Two hydrophobic compounds identified as en-yn-dicycloethers also were determined in all preparations.
It was established that total flavonoids content in oil extract is less than in other preparations because of low solubility of flavonoid glycosides and aglycones in plant oil. Total coumarins quantity in oil extract is higher than in Rotokan, water extract and tincture and less only than in Romazulan.
It was established that ethanol was the most suitable extragent for flavonoids while more hydrophobic compound (coumarins and en-yn-dicycloethers) were abundant in oil extract.
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