SYNTHESIS OF NEW STARCH DERIVATIVES CONTAINING 2-AMINOETHYL HYDROGEN SULFATE

UDC 541.6.69:615.01

  • Jamoliddin Abdugulomovich Abdurakhmanov Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: jamoliddinaa23@gmail.com
  • Shavkat Abduganievich Shomurotov Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: shsha@mail.ru
  • Oliy Ravshanovich Akhmedov Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan, Tashkent Institute of Chemical Technology Email: Oliy86@bk.ru
  • Zhakhongir Asatullaevich Khabibullaev Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: h901804@gmail.com
  • Abbaskhan Sabirkhanovich Turaev Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: abbaskhan@mail.ru
  • Arslon Shernazarovich Khusenov Tashkent Institute of Chemical Technology Email: khusenov_82@mail.ru
  • Umid Davronovich Mukhitdinov Tashkent Institute of Chemical Technology Email: muxitdinovu@mail.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20250115174
Keywords: polysaccharide, starch, sodium periodate, 2-aminoethyl sulfate, azomethine linkage, heparin, anticoagulant activity

Abstract

The article is devoted to the synthesis of new starch derivatives containing 2-aminoethyl sulfate. The study examined the influence of various parameters on the process of modification of polysaccharides, including reaction time, pH of the medium, temperature and concentration of reagents. Optimal reaction conditions were determined. The structure of the resulting product was analyzed using spectroscopy methods, including infrared spectroscopy. Additionally, the nitrogen content in the macromolecule was determined in order to assess the degree of modification, since nitrogen is often introduced into the molecule through amino groups, changing its properties and functionality. The influence of the amount of nitrogen on the formation of azomethine bonds and their distribution in the macromolecule was studied. It has been established that an increase in the number of sulfate groups in a macromolecule leads to an increase in its acidity, which can be an important factor when considering its biological activity. The results obtained represent an important contribution to the understanding of polysaccharide modification processes and their application in various fields of science and industry.

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Author Biographies

Jamoliddin Abdugulomovich Abdurakhmanov , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

PhD student, junior research fellow

Shavkat Abduganievich Shomurotov , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

Doctor of Chemical Sciences, leading research fellow

Oliy Ravshanovich Akhmedov , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan, Tashkent Institute of Chemical Technology

PhD, senior research fellow

Zhakhongir Asatullaevich Khabibullaev , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

junior research fellow

Abbaskhan Sabirkhanovich Turaev , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

Doctor of Chemical Sciences, academician, chief research fellow

Arslon Shernazarovich Khusenov , Tashkent Institute of Chemical Technology

Doctor of Chemical Sciences, professor

Umid Davronovich Mukhitdinov , Tashkent Institute of Chemical Technology

PhD, senior research fellow

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Published
2025-03-07
How to Cite
1. Abdurakhmanov J. A., Shomurotov S. A., Akhmedov O. R., Khabibullaev Z. A., Turaev A. S., Khusenov A. S., Mukhitdinov U. D. SYNTHESIS OF NEW STARCH DERIVATIVES CONTAINING 2-AMINOETHYL HYDROGEN SULFATE // Chemistry of plant raw material, 2025. № 1. P. 68-77. URL: https://journal.asu.ru/cw/article/view/15174.
Issue
No 1 (2025)
Section
Biopolymers of plants

Copyright (c) 2025 chemistry of plant raw material

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