COMPONENT COMPOSITION, ANTIRADICAL AND ANTIMICROBIAL ACTIVITY OF EXTRACTS OF ST. JOHN'S WORT OF THE KRASNOYARSK TERRITORY
ГВС 543.544: 615.322
Abstract
The component composition of aqueous-alcoholic extracts of the above-ground part of St. John's wort grown in the Krasnoyarsk Territory was studied using high-performance liquid chromatography. The highest amount of all compounds was determined in the extract on 40% ethyl alcohol. In combination with the thin-layer chromatography method, the presence of one compound from the group of condensed anthraquinone derivatives, hypericin, was established. The total content of phenolic compounds, the content of flavonoids and tannins in the extracts were determined. The antiradical and antimicrobial activity of the extracts was studied. The maximum value of antiradical activity (100%) was registered for the extract on 40% ethyl alcohol. Extracts prepared in the ratio of raw material : extractant 1 : 100 did not show antimicrobial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. Extracts prepared in a raw material : extractant ratio of 1 : 1 showed some antimicrobial activity only against Staphylococcus aureus (MSSA) and (MRSA).
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