ANALYSIS OF THE COMPOSITION AND PROPERTIES OF RAW BIRCH MUSHROOM, INONOTUS OBLIQUUS (PERS.) PILAT, COLLECTED IN THE TOMSK REGION
Abstract
Triterpenoid content and antioxidant activity of raw birch mushroom, Inonotus obliquus (Pers.) Pilat, collected in the Tomsk region were studied. Lanostane and ergostane tetracyclic triterpenoids were identified in raw material by GC-MS. Some of these compounds are biologically active. For instance, inotodiol was reported to exhibit antitumor activity. The antioxidant activity of aqueous extract was measured and expressed in equivalents of gallic acid. The antioxidant activity showed no dependence on the degree of raw material grinding in the studied particle size range from <0,1 to 4–6 mm.
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Shikov A.N., Pozharitskaya O.N., Makarov V.G., Wagner H., Verpoorte R., Heinrich M. Medicinal Plants of the Russian Pharmacopoeia; their history and applications // Journal of Ethnopharmacology, 2014, vol. 154, №3, pp. 481–536.
Song F.Q., Liu Y., Kong X.S., Chang W., Song G. Progress on understanding the anticancer mechanisms of medicinal mushroom: Inonotus obliquus // Asian Pacific Journal of Cancer Prevention, 2013, vol. 14, №3, pp. 1571–1578.
Zheng W.F., Liu T., Xiang X.Y., Gu Q. Sterol composition in field-grown and cultured mycelia of Inonotus obliquus // Acta pharmaceutica Sinica, 2007, vol. 42, №7, pp. 750–756.
Liu C., Zhao C., Pan H.H., Kang J., Yu X.T., Wang H.Q., Li B.M., Xie Y.Z., Chen R.Y. Chemical constituents from Inonotus obliquus and their biological activities // Journal of Natural Products, 2014, vol. 77, №1, 35–41.
Сысоева М.А., Кузнецова О.Ю., Гамаюрова В.С., Суханов П.П., Зиятдинова Г.К., Будников Г.К. Исследование золя водных извлечений чаги. IV. Антиоксидантная активность. Влияние способа извлечения и применение комплексонов, гидрооксида натрия // Химия растительного сырья, 2005, №1, с. 41–47.
Государственная фармакопея СССР: Выпуск 2. Общие методы анализа. Лекарственное растительное сырье / МЗ СССР. − 11-е изд., доп. − М.: Медицина, 1989.
Хасанов В.В., Рыжова Г.Л., Мальцева Е.В. Исследование антиокислительных свойств соединений с использованием реакции окисления сульфита натрия // Химия растительного сырья, 2004, №3, с. 77–85.
Nomura M., Takahashi T., Uesugi A., Tanaka R., Kobayashi S. Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis // Anticancer Research, 2008, vol. 28, №5A, pp. 2691–2696.
Zhong X.H., Wang L.B., Sun D.Z. Effects of inotodiol extracts from Inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549 // Chinese journal of integrative medicine, 2011, vol. 17, №3, pp. 218–223.
Zhao L.W., Zhong X.H., Yang S.Y., Zhang Y.Z., Yang N.J. Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells // Asian Pacific Journal of Cancer Prevention, 2014, vol. 15, №7, pp. 3195–3199.
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