SYNTHESIS AND STUDY OF PROPERTIES OF POLYMER COMPLEXES OF ETHACYZIN WITH CARBOX-YMETHYLCELLULOSE
Abstract
Last years intensive researches on creation of new prolonged preparations on the basis of natural polymeric carriers with the improved physical and chemical and pharmacological properties have been conducted.
One of approaches to the decision of the given problem is inclusion in a matrix of the polymeric carrier known medicinal preparations that will allow purposefully change their properties and activity. Natural polymers, in particular, polysaccharides, unlike synthetic polymers, are biocompatible and do not show collateral toxic effects in a contact with alive organism, and at the same time can improve bioavailability and prolonged action.
Carboxymethylcellulose macromolecule (CMC) as the carrier for physiologically active substance has great value, thanking its properties such as non-toxicity, biodegradability and etc.
With the purpose of obtaining of the prolonged preparation possessing anti-arrhythmic action, an interaction of Na-CMC with well known anti-arrhythmic preparation of ethacyzin hydrochloride (ETH) is investigated.
Na-CMC having various molecular weight, received by hydrolysis of industrial Na-CMC was used as a polymeric carrier. It is shown, that by the variation of time and molar ratio of mineral acid of system during the process of hydrolysis creates possibility of regulation by the molecular characteristics of polymeric matrix of Na-CMC.
For the first time, a process of synthesis of with the various contents of medicinal components is investigated at a variation of molecular structure of polymer of carrier Na-CMC.
Pharmaco-toxicological studies showed that the polymeric complexes CMC with ETH possess low toxicity in a comparison with ethacyzin, and that, it shows expressed anti-arrhythmic action. An anti-arrhythmic activity of polymeric complex of CMC with ETH is equal to the activity of ETH, but considerably exceeds it on pharmacological properties that prove perspectives of the further researches on it as a prolonged anti-arrhythmic means.Downloads
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Chueshov I. Promyshlennaia tekhnologiia lekarstv: uchebnik. [Industrial technology of medicines: a textbook]. Khar'kov, 2002, 715 p. (in Russ.).
Milovanova L.N. Tekhnologiia izgotovleniia lekarstvennykh form. [Technology of manufacturing dosage forms]. Rostov-na-Donu, 2002, 448 p. (in Russ.).
Muratova S.A., Burkhanova N.D., Iugai S.M., Nikonovich G.V., Pulatova Kh.P., Rashidova S.Sh. Khimiko-farmatsevticheskii zhurnal, 2002, vol. 36, no. 11, pp. 41–43. (in Russ.).
Tentsova A.I., Aliushina M.T. Polimery v farmatsii. [Polymers in pharmacy]. Moscow, 1985, 256 p. (in Russ.).
Krasniuk I.N. Farmatsevticheskaia tekhnologiia: Tekhnologiia lekarstvennykh form. [Pharmaceutical technology: Tech-nology of medicinal forms]. Moscow, 2004, 464 p. (in Russ.).
Boisseau P., Kiparissides C., Pavesio A., Saxl O. et al. European Technology Platform in Nanomedicine – Nanotech-nology for Health, Luxembourg, 2005, 37 p.
Khlusov I.A., Chuchalin V.S., Khoruzhaia T.G. Printsipy sozdaniia i funktsionirovaniia sistem dostavki lekar-stvennykh sredstv. Uchebnoe posobie. [Principles of creation and functioning of drug delivery systems. Tutorial]. Tomsk, 2008, 81 p. (in Russ.).
Khoruzhaia T.G. Transportnye terapevticheskie sistemy dostavki lekarstvennykh veshchestv. [Transport therapeutic drug delivery systems]. Tomsk, 2000, 48 p. (in Russ.).
Petropavlovskii G.A. Gidrofil'nye i chastichno zameshchennye efiry tselliulozy i ikh modifikatsiia putem khi-micheskogo sshivaniia. [Hydrophilic and partially substituted cellulose ethers and their modification by chemical cross-linking]. Len-ingrad, 1988, 298 p. (in Russ.).
Gal'braikh L.S. Sorosovskii obrazovatel'nyi zhurnal, 1996, no. 11, pp. 47–53. (in Russ.).
Bytenskii V.Ia., Kuznetsova E.P. Proizvodstvo efirov tselliulozy. [Production of cellulose ethers]. Leningrad, 1974, 207 p. (in Russ.).
Bolotnikova L.S., Danilov S.N., Samsonova T.I. Zhurnal prikladnoi khimii, 1966, vol. 39, no. 1, pp. 179–180. (in Russ.).
Dusniiazov B.Z. Osobennosti sinteza, prevrashcheniia karboksimetiltselliulozy i rassasyvaiushchiesia gemostatiche-skie materialy na ee osnove : avtoref. diss. … kand. khim. nauk. [Features of synthesis, transformation of carbox-ymethylcellulose and absorbable hemostatic materials on its basis : the author's abstract. diss. ... cand. chem. sciences.]. Tashkent, 1993, 23 p. (in Russ.).
Khaitmetova S.B., Shomurotov Sh.A., Mukhamedzhanova M.Iu., Turaev A.S. Aktual'nye voprosy obrazovaniia, nauki i proizvodstva v farmatsii : tezisy dokladov nauchno-prakticheskaia konferentsiia. [Actual issues of education, science and production in pharmacy : theses of the reports scientific and practical conference]. Tashkent, 2008, pp. 120–121. (in Russ.).
Khaitmetova S.B., Shomurotov Sh.A., Mukhamedzhanova M.Iu., Turaev A.S. Aktual'nye problemy khimii prirodnikh soedinenii : tezisy dokladov mezhdunarodnoi konferentsii. [Actual problems of the chemistry of natural compounds : theses of the reports of the international conference]. Tashkent, 2009, p. 165. (in Russ.).
Khaitmetova S.B., Turaev A.S. Uzbekskii khimicheskii zhurnal, 2011, special issue, pp. 12–15. (in Russ.).
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