QUANTITATIVE DETERMINATION OF HYPERFORIN DERIVATIVES IN THE HERB OF HYPERICUM PER-FORATUM
Abstract
The way of determination of spectrophotometric method of hyperforin derivatives in the herb of Hypericum perforatum was developed. The relative error of determination doesn´t exceed 1,5%. It is shown that hyperforin derivatives are practically absent in the herb of Hypericum maculatum (this is different kind of Hypericum allowed for use), which causes its lower antimicrobial activity in comparison with Hypericum perforatum. Hyperforin derivatives are localized predominatly in the flowers of Hypericum perforatum.Downloads
Metrics
References
Государственная фармакопея СССР: Вып. 2. Общие методы анализа. Лекарственное растительное сырье. 11-е изд., доп. М., 1989. 400 с.
Государственная Фармакопея СССР. 10-е изд., М., 1968. 1080 с.
European Pharmacopoeia. 5th ed. Sup. 5.6. Strasbourg, 2005.
Гуревич А.И., Добрынин М.Н., Колосов С.А., Поправко И.Д., Айзенман В.Е., Гарагуля А.Д. Гиперфорин – антибиотик из Hypericum perforatum L. // Антибиотики. 1971. №16. С. 510–513.
ФС 42-1348-91. Раствор хлорофиллипта спиртовый 1%. Фармакопейный государственный комитет. Введ. 10.10.91. М., 1991. 4 с.
Adam P., Arigoni D., Bacher A., Eisenreich W. Biosynthesis of Hyperforin Hypericum perforatum // J. Med. Chem. 2002. Vol. 45. Pp. 4786-4793.
Быстров, Н.С., Добрынин В.Н., Колосов М.Н., Чернов Б.К. Химия гиперфорина. VI. Общая химическая ха-рактеристика // Биоорганическая химия. 1978. Т. 4, №6. С. 791–797.

This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.







