COMPARATIVE PHARMACOGNOSTIC STUDY OF DIFFERENT ORIGIN LOW WOODY-GRASS TYPES PEATS FOR SUBSTANTIATION OF THEIR USE AS PROSPECTIVE SOURCES OF BIOLOGICALLY ACTIVE HUMIC ACIDS

UDC 631.41:631.417

  • Lyudmila Anatol'yevna Logvinova Siberian State Medical University Email: ludmila_logvinova@mail.ru
  • Mariya Vladimirovna Zykova Siberian State Medical University Email: gmv2@rambler.ru
  • Sergey Vladimirovich Krivoshchekov Siberian State Medical University Email: ksv_tsu@mail.ru
  • Larisa Aleksandrovna Drygunova Siberian State Medical University Email: l_drygunova@mail.ru
  • Irina Aleksandrovna Perederina Siberian State Medical University Email: perederina.irina@yandex.ru
  • Ol'ga Aleksandrovna Golubina Siberian State Medical University Email: mtgolubin@yandex.ru
  • Irina Vasil'yevna Perminova Moscow State University named after M.V. Lomonosov Email: iperminova@gmail.com
  • Andrey Ivanovich Konstantinov Moscow State University named after M.V. Lomonosov Email: konstant@med.chem.msu.ru
  • Mikhail Valer'yevich Belousov Siberian State Medical University Email: mvb63@mail.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20220110663
Keywords: peat, humic acids, elemental analysis, spectroscopy, chromatography

Abstract

The comparative pharmacognostic study of two different origin low woody-grass types peat from the Tomsk region peatlands and the physicochemical parameters of the structure of humic acids (HA) isolated from them was carried out to justify the interchangeability of peat raw materials within the same peat species and to select a promising source of HA with biological activity for development new drug candidates with non-specific biological activity. As a result of the study, it was established that two different origin low woody-grass types peat from the Tomsk region peatlands ("Klyukvennoye" and "Tagan") have similar botanical composition and pharmacognostic parameters. Humic acids were alkaline extraction isolated from the studied peats, according to the physicochemical methods combination (UV and IR spectroscopy, elemental CHNS analysis, 13C-NMR spectroscopy, titrimetry) have common structural features due to the presence of the aromatic structures with the aliphatic radicals replaced, the the polyconjugated system presence, the aromaticity same degrees, the hydrophilic structures predominance over hydrophobic, polydispersity, pronounced reducing properties, this indicates the interchangeability of peat raw materials, provided that the technology for extracting HA from peat is observed. Difference features between HA samples, associated mainly with the nitrogen content, as well as phenolic and quinoid fragments, the condensation aromatic structures degrees, the lignin nature methoxyl-groups and carbohydrate fragments, were made it possible to conclude about that HA extracted from peat of «Tagan» peatland are more promising for the development to safe naturals medicines for the prevention and treatment of a wide range of pathologies.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Lyudmila Anatol'yevna Logvinova, Siberian State Medical University

кандидат фармацевтических наук, ассистент кафедры химии

Mariya Vladimirovna Zykova, Siberian State Medical University

доктор фармацевтических наук, доцент, заведующий кафедрой химии, профессор кафедры фармацевтического анализа

Sergey Vladimirovich Krivoshchekov, Siberian State Medical University

кандидат химических наук, доцент кафедры фармацевтического анализа

Larisa Aleksandrovna Drygunova, Siberian State Medical University

кандидат химических наук, доцент кафедры фармацевтического анализа

Irina Aleksandrovna Perederina, Siberian State Medical University

кандидат химических наук, доцент кафедры химии

Ol'ga Aleksandrovna Golubina, Siberian State Medical University

кандидат химических наук, доцент кафедры химии

Irina Vasil'yevna Perminova, Moscow State University named after M.V. Lomonosov

доктор химических наук, профессор, заведующий научно-исследовательской лабораторией природных гуминовых систем кафедры медицинской химии и тонкого органического синтеза

Andrey Ivanovich Konstantinov, Moscow State University named after M.V. Lomonosov

кандидат химических наук, старший научный сотрудник научно-исследовательской лабораторией природных гуминовых систем кафедры медицинской химии и тонкого органического синтеза

Mikhail Valer'yevich Belousov, Siberian State Medical University

доктор фармацевтических наук, заведующий кафедрой фармацевтического анализа

References

Orlov D.S. Gumusovyye kisloty pochv i obshchaya teoriya gumifikatsii. [Soil humic acids and the general theory of humification]. Moscow, 1990, 325 p. (in Russ.).

Zykova M.V., Logvinova L.A., Belousov M.V. Traditsionnaya meditsina, 2018, no. 2 (53), pp. 27–38. (in Russ.).

van Rensburg C.E. Phytotherapy Research, 2015, vol. 29, pр. 791–795. DOI: 10.1002/ptr.5319.

Zykova M.V., Schepetkin I.A., Belousov M.V., Krivoshchekov S.V., Logvinova L.A., Bratishko K.A., Romanen-ko S.V., Yusubov M.S., Quinn M.T. Molecules, 2018, vol. 23, no. 4, p. 753. DOI: 10.3390/molecules23040753.

Zykova M.V., Logvinova L.A., Krivoshchekov S.V., Voronova O.A., Lasukova T.V., Bratishko K.A., Zholobova G.A., Golubina O.A., Perederina I.A., Drygunova L.A., Tveryakova Ye.N., Belousov M.V. Khimiya rastitel'nogo syr'ya, 2018, no. 3, pp. 239–250. DOI: 10.14258/jcprm.2018033925. (in Russ.).

Zykova M.V., Belousov M.V., Logvinova L.A., Lasukova T.V., Gorbunov A.S., Dygai A.M. Bulletin of Experimental Biology and Medicine, 2017, vol. 163, no. 2, pp. 206 209. DOI: 10.1007/s10517-017-3767-1.

Lasukova T.V., Zykova M.V., Belousov M.V., Gorbunov A.S., Logvinova L.A., Dygai A.M. Bulletin of Experimental Biology and Medicine, 2019, vol. 166, no. 5, pp. 598–601. DOI: 10.1007/s10517-019-04399-y.

Bratishko K.A., Zykova M.V., Ivanov V.V., Buyko Ye.Ye., Drygunova L.A., Perminova I.V., Belousov M.V. Khimiya rastitel'nogo syr'ya, 2021, no. 1, pp. 287–298. DOI: 10.14258/jcprm.2021018784. (in Russ.).

Buyko Ye.Ye., Zykova M.V., Ivanov V.V., Bratishko K.A., Ufandeyev A.A., Grigor'yeva I.O., Tsupko A.V., Mikhalov D.A., Perminova I.V., Belousov M.V. Razrabotka i registratsiya lekarstvennykh sredstv, 2021, vol. 10, no. 4, pp. 46–53. DOI: 10.33380/2305-2066-2021-10-4-46-53. (in Russ.).

Belousov M.V., Akhmedzhanov R.R., Zykova M.V., Gur’ev A.M., Yusubov M.S. Pharmaceutical Chemistry Jour-nal, 2014, vol. 48, no. 4, pp. 249–252. DOI: 10.1007/s11094-014-1088-5.

Zamoshchina T.A., Gostyukhina A.A., Zaitsev K.V., Abdulkina N.G., Zykova M.V., Logvinova L.A., Svetlik M.V., Kurtsevich E.A., Belousov M.V., Lasukova T.V., Dygai A.M. Bulletin of experimental biology and medicine, 2020, vol. 169, no. 6, pp. 734–737. DOI: 10.1007/s10517-020-04967-7.

Trofimova E.S., Zykova M.V., Ligacheva A.A., Sherstoboev E.Yu., Zhdanov V.V., Belousov M.V., Yusubov M.S., Krivoshchekov S.V., Danilets M.G., Dygai A.M. Bulletin of Experimental Biology and Medicine, 2016, vol. 161, no. 5, pp. 687–692. DOI: 10.1007/s10517-016-3486-z.

Trofimova E.S., Zykova M.V., Ligacheva A.A., Sherstoboev E.Yu., Zhdanov V.V., Belousov M.V., Yusubov M.S., Krivoshchekov S.V., Danilets M.G., Dyga A.M. Bulletin of Experimental Biology and Medicine, 2016, vol. 162, no. 6, pp. 741–745. DOI: 10.1007/s10517-017-3702-5.

Trofimova Ye.S., Zykova M.V., Ligacheva A.A., Danilets M.G., Sherstoboyev Ye.Yu., Logvinova L.A., Belousov M.V. Byulleten' eksperimental'noy biologii i meditsiny, 2021, vol. 172, no. 9, pp. 313–317. DOI: 10.47056/0365-9615-2021-172-9-313-317. (in Russ.).

Zykova M.V., Veretennikova E.E., Logvinova L.A., Romanenko S.V., Bratishko K.A., Belousov M.V., Brazov-sky K.S., Yusubov M.S., Lyapkov A.A., Danilets M.G., Trofimova E.S., Ligacheva A.A. Environmental research. 2020, vol. 191, p. 109999. DOI: 10.1016/j.envres.2020.109999.

Gostishcheva M.V., Belousov M.V., Ismatova R.R., Vasil'yev K.Yu., Dmitruk S.Ye., Yusubov M.S. Bashkirskiy khimicheskiy zhurnal, 2009, vol. 15, no. 2, pp. 67–71. (in Russ.).

Arkhipov V.S., Maslov V.G. Khimiya rastitel'nogo syr'ya, 1998, no. 4, pp. 9 16. (in Russ.).

Patent 2610446 (RU). 2017. (in Russ.).

GOST 28245-89. Torf. Metody opredeleniya botanicheskogo sostava i stepeni razlozheniya. [GOST 28245-89. Peat. Methods for determining the botanical composition and degree of decomposition]. Moscow, 2006, 7 p. (in Russ.).

Gosudarstvennaya Farmakopeya Rossiyskoy Federatsii. XIV izdaniye. [State Pharmacopoeia of the Russian Federa-tion. XIV edition]. Moscow, 2018. URL: http://www.femb.ru/feml. (in Russ.).

Kosuke I., Akira W. Analytical and Bioanalytical Chemistry, 2015, vol. 402 (2), pp. 651 655. DOI: 10.1007/s00216-015-9127-y.

Orlov D.S. Guminovyye veshchestva v biosfere. [Humic substances in the biosphere]. Moscow, 1993, 238 p. (in Russ.).

Shiping W., Meng W., Guilong L., Ming L., Chunyu J., Zhongpei L. J. Agric. Food Chem., 2018, vol. 66, no. 28, pp. 7514–7521. DOI: 10.1021/acs.jafc.8b01931.

Maryganova V.V., Bambalov N.N., Strigutskiy V.P., Parmon S.V. Khimiya tverdogo topliva, 2013, no. 3, pp. 19 30. DOI: 10.7868/S0023117713030055. (in Russ.).

Lishtvan I.I., Kaputskiy F.N., Yanuta Yu.G., Abramets A.M., Monich G.S., Navosha Yu.Yu., Strigutskiy V.P., Glukhova N.S., Aleynikova V.N. Vestnik BGU. Seriya 2: Khimiya. Biologiya. Geografiya, 2012, no. 1, pp. 18–23. (in Russ.).

Nesterova O.V., Semal' V.A. Vestnik KrasGAU, 2009, no. 10, pp. 29–35. (in Russ.).

Lishtvan I.I., Yanuta Yu.G., Abramets A.M., Navosha Yu.Yu., Strigutskiy V.P., Kaputskiy F.N. Khimiya tverdogo topliva, 2006, no. 4, pp. 3–11. (in Russ.).

Zaccone C., Miano T.M., Shotyk W. Organic Geochemistry, 2007, vol. 38, no. 1, pp. 151 160. DOI: 10.1016/j.orggeochem.2006.06.023.

Zherebker A., Kostyukevich Y., Kononikhin A., Kharybin O., Konstantinov A.I. Anal. Bioanal. Chem., 2017, vol. 409, no. 9, pp. 2477–2488. DOI: 10.1007/s00216-017-0197-x.

Shin H.S., Monsallier J.-M., Choppin G.R. Talanta, 1999, vol. 50, no. 3, pp. 641–647. DOI: 10.1016/S0039-9140(99)00161-7.

Kholodov V.A., Konstantinov A.I., Kudryavtsev A.V., Perminova I.V. Pochvovedeniye, 2011, no. 9, pp. 1064–1073. (in Russ.).

Hertkorn N., Permin A.B., Perminova I.V., Kovalevskii D.V., Yudov M.V., Kettrup A. Journal Environmental Quali-ty, 2002, vol. 31, no. 2, pр. 375–387. DOI: 10.2134/jeq2002.3750.

Tadini A.M., Pantano G., Toffoli A.L., Fontaine B., Spaccini R., Piccolo A., Moreira A.B., Bisinoti M.C. Science of the total environment, 2015, vol. 506–507, pp. 234–240. DOI: 10.1016/j.scitotenv.2014.11.012.

Amir S., Jouraiphy A., Meddich A., Meddich A., El Gharous M., Winterton P., Hafid M. Journal of Hazardous Ma-terials, 2010, vol. 177, no. 1–3, pp. 524–529. DOI: 10.1016/j.jhazmat.2009.12.064.

Published
2022-03-10
How to Cite
1. Logvinova L. A., Zykova M. V., Krivoshchekov S. V., Drygunova L. A., Perederina I. A., Golubina O. A., Perminova I. V., Konstantinov A. I., Belousov M. V. COMPARATIVE PHARMACOGNOSTIC STUDY OF DIFFERENT ORIGIN LOW WOODY-GRASS TYPES PEATS FOR SUBSTANTIATION OF THEIR USE AS PROSPECTIVE SOURCES OF BIOLOGICALLY ACTIVE HUMIC ACIDS // chemistry of plant raw material, 2022. № 1. P. 277-288. URL: http://journal.asu.ru/cw/article/view/10663.
Issue
No 1 (2022)
Section
Peat and products of its processing

Copyright (c) 2022 chemistry of plant raw material

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors, which are published in this journal, agree to the following conditions:

1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .

2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.

3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.