THE STUDY OF NETTLE HERB (URTICA DIOICA L.) GROWING IN SOME AREAS OF THE EUROPEAN RUSSIA AND SIBERIA

UDC 582.635.5:543.54:547.56:628.926.7

  • Nadezdha Valentinovna Isaykina Siberian State Medical University Email: isaikina74@mail.ru
  • Natal'ya Eduardovna Kolomiyets Siberian State Medical University; Kemerovo State Medical University https://orcid.org/0000-0003-0520-921X Email: borkol47@mail.ru
  • Natal'ya Yur'yevna Abramets Siberian State Medical University Email: abrameznu@mail.ru
  • Andrey Aleksandrovich Marin Kemerovo State Medical University Email: mfandr@mail.ru
Keywords: Urtica dioica L., nettle herb, sustainable development, rational use, chlorogenic acid, baicalein, chrysoeriol, scutellarin, HPLC

Abstract

The report presents the results of the study of the chemical composition of nettle herb, 40%, 70% extracts, and extracts of polyphenolic complexes (PPC). Nettle herb were collected by the authors in June-July 2007–2020 in the territories of Tomsk, Kemerovo, Kursk, Novosibirsk, Moscow, Kirov, Tver regions, Altai and Krasnoyarsk Krai; Altai Republic. Extracts, polyphenolic and polysaccharide complexes were obtained from the herb. The studies was conducted using PC, TLC, UV-spectroscopy, HPLC, titrimetry, neutron activation. Reverse-phase HPLC were carried out on a chromatograph «Dionex Ultimate 3000» with UV-detector in the wave length range from 254 to 330 nm. Separation was performed by a column with reversed-phase sorbent «Restek Pinnacle IIC18» (150×4.6 mm, particle size 5 µm), flow rate of mobile phase is 1 ml/min; temperature is 20 °C, mobile phase (50 ml of acetonitrile, 50 ml of 0.1% trifluoroacetic acid) were carried out on. The study showed that nettle herb, 40%, 70% extracts and PPC contain phenolic compounds: phenolcarbonic acids, flavonoids, catechins, tannins; vitamin C and pigments. Baicalein, chrysoeriol, scutellarin identified for the first time. One of the dominant groups is hydroxycinnamic acids. The composition of flavonoids, phenolic carboxylic acids, catechins, hydroxycinnamic acids, including chlorogenic acid, chlorophyll, the sum of phenolic compounds, catechins are similar in 70% extract and its PPC. Additional information was obtained on the elements contained in nettle herb and its extracts.

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Author Biographies

Nadezdha Valentinovna Isaykina, Siberian State Medical University

кандидат фармацевтических наук, доцент кафедры фармацевтического анализа

Natal'ya Eduardovna Kolomiyets, Siberian State Medical University; Kemerovo State Medical University

доктор фармацевтических наук, профессор кафедры фармацевтического анализа, профессор кафедры фармации

Natal'ya Yur'yevna Abramets, Siberian State Medical University

доцент кафедры фарматического анализа

Andrey Aleksandrovich Marin, Kemerovo State Medical University

кандидат фармацевтических наук, доцент кафедры фармации

References

Gosudarstvennyy reyestr lekarstvennykh sredstv [State register of medicines]. URL: https://www.grls.rosminzdrav.ru. (in Russ.).

Gosudarstvennaya farmakopeya Rossiyskoy Federatsii XIV izdaniya. [State Pharmacopoeia of the Russian Federation XIV edition]. Moscow, 2018. URL: http://resource.rucml.ru/feml/pharmacopia/14_4/HTML/index.html. (in Russ.).

Japanese Pharmacopoeia 15 ed., 2006, 1802 p.

Pharmacopee Francaise. 10 edition, 6 supplement: Monographies de souches pour preparations homeopathiques. Paris, 1989, 686 p.

European Pharmacopoeia 8th Edition. Council of Europe European-European Directorate for the Quality of Medi-cines, 2013, vol. 1, 1380 p.

Dhouibi R., Affes H., Ben M., Serria S., Zouheir H., Khaled S., Zeghal M., Ksouda K. Progress in Biophysics and Molecular Biology, 2020, vol. 150, pp. 67–77. DOI: 10.1016/j.pbiomolbio.2019.05.008.

Borsuk O.S., Masnaya N.V., Sherstoboyev Ye.Yu., Isaykina N.V., Kalinkina G.I. Sbornik trudov X mezhdunarodnogo kongressa «Sovremennyye problemy allergologii, immunologii i immunofarmakologii». [Proceed-ings of the X International Congress "Modern problems of allergology, immunology and immunopharmacology"]. Tomsk, 2009, vol. 3, pp. 230–231. (in Russ.).

Borsuk O.S., Masnaya N.V., Sherstoboyev Ye.Yu., Isaykina N.V., Kalinkina G.I. Materialy Mezhdunarodnoy konferentsii «Aktual'nyye voprosy farmatsevticheskoy nauki i obrazovaniya». [Proceedings of the international confer-ence "Actual issues of pharmaceutical science and education"]. Tomsk, 2011, pp. 36–40. (in Russ.).

Patent 2385732 (RU). 2010. (in Russ.).

Feng X.-R., Ju P.-J., Chen Y., Li X.-B., Wang M.-Y. Chinese Herbal Medicines, 2021, pp. 1–5. DOI: 10.1016/j.chmed.2021.09.008.

Wang M.-Y., Zhang Y., Zhang H., Feng X.-R., Li X.-B. Journal of Asian Natural Products Research, 2019, vol. 21, no. 6, pp. 516–521. DOI: 10.1080/10286020.2018.1457652.

Zhang H., Zhang Y., Wang M.-Y., Chen S., Li X.-B. Journal of Asian Natural Products Research, 2019, vol. 21, no. 11, pp. 1068–1074. DOI: 10.1080/10286020.2018.1563074.

Zhang Y., Liu J., Guo Z., Li X., Wang M. Nat. Prod. Res., 2021, vol. 35, no. 18, pp. 3011–3017. DOI: 10.1080/14786419.2019.1684279.

Wang M., Wu L., Zhang H., Ren D.Z.C., Liu T., Li X. Chemistry of Natural Compounds, 2019, vol. 55, no. 5, pp. 839–842. DOI: 10.1007/s10600-019-02827-z.

Ushanova V.M., Lebedeva O.I., Repyakh S.M. Khimiya rastitel'nogo syr'ya, 2001, no. 3, pp. 97–104. (in Russ.).

Yatsyuk V.Ya., Chalyy G.A., Soshnikova O.V. Rossiyskiy mediko-biologicheskiy vestnik imeni akademika I.P. Pavlova, 2006, vol. 14, no. 1, pp. 25–29. DOI: 10.17816/PAVLOVJ2017130-41. (in Russ.).

Taïbi K., Abderrahim L.A., Ferhat K., Betta S., Taïbi F., Bouraada F., Boussaid M. Saudi Pharmaceutical Journal, 2020, vol. 28, no. 11, pр. 1451–1465. DOI: 10.1016/j.jsps.2020.09.011.

Yener Z., Celik I., Ilhan F., Bal R. Food Chem. Toxicol., 2009, vol. 47, no. 2, pp. 418–424. DOI: 10.1016/j.fct.2008.11.031.

Konrad A., Mähler M., Arni S., Flogerzi B., Klingelhöfer S., Seibold F. Int. J. Colorectal Dis., 2005, vol. 20, pp. 9–17. DOI: 10.1007/s00384-004-0619-z.

Uyar A., Yener Z., Dogan A. Br. Poult. Sci., 2016, vol. 57, no. 2, pp. 235–245. DOI: 10.1080/00071668.2015.1129664.

Tita B., Faccendini P., Bello U., Martinoli L., Bolle P. Pharmacol. Res., 1993, vol. 27, no. 1, pp. 21–22. DOI: 10.1006/phrs.1993.1141.

Dhouibi R., Moalla D., Ksouda K., Ben Salem M., Hammami S., Sahnoun Z., Zeghal K.M., Affes H. Arch. Physiol. Biochem., 2017, pp. 1–9. DOI: 10.1080/13813455.2017.1402352.

Kalinkina O.V., Sychev I.A. Rossiyskiy mediko-biologicheskiy vestnik im. akad. I.P. Pavlova, 2014, vol. 22, no. 1, pp. 153–158. DOI: 10.17816/PAVLOVJ20141153-158. (in Russ.).

Burmistrova O.M., Burmistrov Ye.A. Materialy Mezhdunarodnoy nauchno-prakticheskoy konferentsii Stav-ropol'skogo gosudarstvennogo agrarnogo universiteta «Prioritetnyye i innovatsionnyye tekhnologii v zhivotnovodstve – osnova modernizatsii agropromyshlennogo kompleksa Rossii». [Proceedings of the International Scientific and Prac-tical Conference of the Stavropol State Agrarian University "Priority and innovative technologies in animal husbandry - the basis for the modernization of the agro-industrial complex of Russia"]. Stavropol', 2016, pp. 26–31. (in Russ.).

Lapkina Ye.Z., Makarskaya G.V., Tirranen L.S. Vestnik KrasGAU, 2016, no. 12, pp. 44–50. (in Russ.).

Georgiyevskiy V.P., Komisarenko N.F., Dmitruk S.Ye. Biologicheski aktivnyye veshchestva lekarstvennykh ras-teniy. [Biologically active substances of medicinal plants]. Novosibirsk, 1990, 336 p. (in Russ.).

Fedoseyeva L.M. Khimiya rastitel'nogo syr'ya, 2005, no. 3, pp. 45–50. (in Russ.).

Trineyeva O.V., Voropayeva S.V., Slivkin A.I. Sorbtsionnyye i khromatograficheskiye protsessy, 2013, vol. 13, no. 2, pp. 213–219. (in Russ.).

Bobina Ye.A., Shishorina L.A., D'yakova N.A. Smolenskiy meditsinskiy al'manakh, 2021, no. 1, pp. 48–51. (in Russ.).

Ligostayeva Yu.V., Kachkin K.V. Naukosfera, 2021, no. 6-1, pp. 36–39. DOI: 10.5281/zenodo.495433. (in Russ.).

Kolomiyets N.E., Kalinkina G.I., Sapronova N.N. Farmatsiya, 2011, no. 6, pp. 22–24. (in Russ.).

Trineyeva O.V., Slivkin A.I., Safonova Ye.F. Khimiya rastitel'nogo syr'ya, 2015, no. 3, pp. 105–110. DOI: 10.14258/jcprm.201503522. (in Russ.).

Trineyeva O.V., Slivkin A.I. Razrabotka i registratsiya lekarstvennykh sredstv, 2016, no. 1, pp. 142–148. DOI: 10.14258/jcprm.201503522. (in Russ.).

Skalozubova T.A. Izucheniye metaboloma syr'ya i lekarstvennykh form krapivy dvudomnoy: avtoref. diss. … kand. farm. nauk. [The study of the metabolome of raw materials and dosage forms of stinging nettle: abstract of the thesis diss. … cand. farm. Sciences]. Moscow, 2013, 24 p. (in Russ.).

Trineyeva O.V., Slivkin A.I. Nauchnyye vedomosti. Seriya Meditsina. Farmatsiya, 2015, no. 22 (219), pp. 169–174. (in Russ.).

Balagozyan E.A., Kurkin V.A., Pravdivtseva O.Ye. Farmatsiya i farmakologiya, 2016, vol. 4, no. 2 (15), pp. 71–78. DOI: 10.19163/2307-9266-2016-4-2(15)-71-78. (in Russ.).

Published
2022-03-07
How to Cite
1. Isaykina N. V., Kolomiyets N. E., Abramets N. Y., Marin A. A. THE STUDY OF NETTLE HERB (URTICA DIOICA L.) GROWING IN SOME AREAS OF THE EUROPEAN RUSSIA AND SIBERIA // chemistry of plant raw material, 2022. № 3. P. 127-138. URL: http://journal.asu.ru/cw/article/view/10873.
Section
Low-molecular weight compounds