THE STUDY OF ANTIMICROBIAL AND ANALGESIC ACTIVITY OF CERTAIN CYTIZINE ALKALOID COMBINED DERIVATIVES

UDC 547.973: 615.1

  • Gulim Kenesbekovna Mukusheva Karagandy University of the name of Academician E.A. Buketov Email: mukusheva1977@list.ru
  • Roza Battalovna Seidakhmetova Karagandy University of the name of Academician E.A. Buketov Email: rozabat@mail.ru
  • Aigerim Rysbekovna Zhassymbekova Karagandy University of the name of Academician E.A. Buketov Email: aigera-93-93@mail.ru
  • Oralgazy Aktaevich Nurkenov Institute of Organic Synthesis and Coal Chemistry Email: nurkenov_oral@mail.ru
  • Zhangeldy Seitovich Nurmaganbetov Institute of Organic Synthesis and Coal Chemistry Email: nzhangeldy@yandex.ru
  • Tulegen Muratovich Seilkhanov Sh.Ualikhanov Kokshetau university
  • Aizhan Maratovna Tazhybay Karagandy University of the name of Academician E.A. Buketov Email: aika_93_16@mail.ru
  • Alisher Sabyrovich Mazhytov Karagandy University of the name of Academician E.A. Buketov Email: kazakh-2015@inbox.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20220411247
Keywords: alkaloids, cytisine, quinine, lupinine, combined derivatives, pharmacological activity

Abstract

The modern vegetable matter studies in the republic and abroad are devoted to a multi-faceted and comprehensive research of plant raw materials, including desorbing and structure of plant component chemical properties, the study of their biological activity, as well as the development of effective and environmentally friendly methods for соmprehensive mineral processing of plant raw materials.

The 1,2,3-triazoles attraction is due to their reactivity versatility, as well as practical application of 1,2,3-triazole derivatives as medicines. Modification of natural compound molecules by introducing such a substituent is one of promising directions in the search for new biologically active compounds.

According to the data obtained, the antimicrobial activity of sample (5) is higher than that of sample (3). Thus, sample (5) showed a moderate antibacterial activity against Escherichia coli, whereas sample (3) showed a weak antimicrobial activity against this test strain.

The analysis of test results concerning the analgesic activity assessment showed that samples (5) and (3) can reduce the rats ‘specific nociceptive responses severity when testing abdominal constriction. It is important to emphasize that when injecting a 1% acetic acid solution abdominally, all test animals developed “acetic writhing’s” (characteristic animal movements, including the abdominal muscles contraction, alternating with their relaxation, hind limbs stretching and back arching).

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Author Biographies

Gulim Kenesbekovna Mukusheva, Karagandy University of the name of Academician E.A. Buketov

кандидат химических наук, ассоциированный профессор кафедры неорганической и технической химии

Roza Battalovna Seidakhmetova, Karagandy University of the name of Academician E.A. Buketov

кандидат медицинских наук

Aigerim Rysbekovna Zhassymbekova, Karagandy University of the name of Academician E.A. Buketov

PhD докторант

Oralgazy Aktaevich Nurkenov, Institute of Organic Synthesis and Coal Chemistry

доктор химических наук, профессор

Zhangeldy Seitovich Nurmaganbetov, Institute of Organic Synthesis and Coal Chemistry

кандидат химических наук, ассоциированный профессор института органического синтеза и углехимии

Tulegen Muratovich Seilkhanov, Sh.Ualikhanov Kokshetau university

кандидат химических наук, профессор

Aizhan Maratovna Tazhybay, Karagandy University of the name of Academician E.A. Buketov

преподаватель кафедры органической химии и полимеров

Alisher Sabyrovich Mazhytov, Karagandy University of the name of Academician E.A. Buketov

студент

References

Prakash B. Kujur A., Yadav A. Synthesis of Medicinal Agents from Plant. Elsevier Ltd., 2018, pp. 25–46. DOI: 10.1016/b978-0-08-102071-5.00002-7.

Thomford N.E., Senthebane D.A., Rowe A., Munro D., Seele P., Maroyi A., Dzobo K. Int. J. Mol. Sci., 2018, vol. 19, no. 6, p. 1578. DOI: 10.3390/ijms19061578.

Heinrich M., Mah J., Amirkia V. Molecules, 2021, vol. 26, no. 7, p. 1836. DOI: 10.3390/molecules26071836.

Ng Y.P., Or T.C.T., Ip N.Y. Neurochemistry International, 2015, vol. 89, pp. 260–270. DOI: 10.1016/j.neuint.2015.07.018.

Bondarenko S.P., Frasinyuk M.S., Vinogradova V.I., Khilya V.P. Khimiya prirodnykh soyedineniy, 2011, no. 4, pp. 536–538. (in Russ.).

Bondarenko S.P., Frasinyuk M.S., Vinogradova V.I., Khilya V.P. Khimiya prirodnykh soyedineniy, 2010, no. 5, pp. 649–651. (in Russ.).

Frasinyuk M.S., Turov A.V., Vinogradova V.I., Khilya V.P. Khimiya prirodnykh soyedineniy, 2007, no. 3, pp. 237–241. (in Russ.).

Frasinyuk M.S., Turov A.V., Vinogradova V.I., Khilya V.P. Khimiya prirodnykh soyedineniy. 2007, no. 2, pp. 145–148. (in Russ.).

Tlegenov R.T., Aytmagambetov A. Bioorganicheskaya khimiya, 2005, pp. 549–552. (in Russ.).

Yadav P.P., Gupta P., Chaturvedi A.K., Shukla P.K., Maurya R. Bioorganic & Medicinal Chemistry, 2005, vol. 13, no. 5, pp. 1497–1505.

Rouden J., Lasne M.-C., Blanchet J., Baudoux J. Chemical Reviews, 2013, vol. 114, no. 1, pp. 712–778. DOI: 10.1021/cr400307e.

Makara N.S., Gabdrakhmanova S.F., Sapozhnikova T.A., Khisamutdinova R.Y., Koval’skaya A.V., Tsypysheva I.P., Zarudii F.S. Pharmaceutical Chemistry Journal, 2015, vol. 49, no. 5, pp. 301–303. DOI: 10.1007/s11094-015-1283-z.

Tasso B., CanuBoido C., Terranova E., Gotti C., Riganti L., Clementi F., Artali R., Bombieri G., Meneghetti F., Spara-tore F. Journal of Medicinal Chemistry, 2009, vol. 52, no. 14, pp. 4345–4357. DOI: 10.1021/jm900225j.

Marrière E., Rouden J., Tadino V., Lasne M.-C. Organic Letters, 2000, vol. 2, no. 8, pp. 1121–1124. DOI: 10.1021/ol005685m.

Taly A., Corringer P.-J., Guedin D., Lestage P., Changeux, J.-P. Nature Reviews Drug Discovery, 2009, vol. 8, no. 9, pp. 733–750. DOI: 10.1038/nrd2927.

Molyneux R.J., Panter K.E. The Alkaloids: Chemistry and Biology. Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Sydney, Tokyo, Academic Press, 2009, pp. 143–216. DOI: 10.1016/s1099-4831(09)06703-0.

Kamarul Zaman M.A., Azzeme A.M. GSC Biological and Pharmaceutical Sciences, 2019, vol. 06, no. 2, pp. 21–29. DOI: 10.30574/gscbps.2019.6.2.0003.

Golobokova T.V., Proydakov A.G., Kizhnyayev V.N. Zhurnnal organicheskoy khimii, 2020, pp. 442–450. DOI: 10.31857/S0514749220030143. (in Russ.).

Nurkenov O.A., Baykenova G.G., Turdybekov D.M., Ibrayev M.K., Gazaliyev A.M., Turdybekov K.M. Zhurnal ob-shchey khimii, 2006, vol. 76, no. 1, pp. 132–134. (in Russ.).

Brel V.K. Russian Journal Organic Chemistry, 2016, vol. 52, no. 1, pp. 54–60.

Artyushin O.I., Moiseeva A.A., Zarubaev V.V., Slita A.V., Galochkina A.V., Muryleva A.A., Borisevich S.S., Ya-rovaya O.I. Chemistry Biodiversity, 2019, vol. 16, no. 11, e1900340. DOI: 10.1002/cbdv.201900340.

Khabriyev R.U. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh vesh-chestv. [Guidelines for the experimental (preclinical) study of new pharmacological substances]. Moscow, 2005, 832 p. (in Russ.).

Gosudarstvennaya farmakopeya Respubliki Kazakhstan. [State Pharmacopoeia of the Republic of Kazakhstan]. Al-maty, 2008, vol. 1, 592 p. (in Russ.).

Published
2022-12-15
How to Cite
1. Mukusheva G. K., Seidakhmetova R. B., Zhassymbekova A. R., Nurkenov O. A., Nurmaganbetov Z. S., Seilkhanov T. M., Tazhybay A. M., Mazhytov A. S. THE STUDY OF ANTIMICROBIAL AND ANALGESIC ACTIVITY OF CERTAIN CYTIZINE ALKALOID COMBINED DERIVATIVES // chemistry of plant raw material, 2022. № 4. P. 259-267. URL: http://journal.asu.ru/cw/article/view/11247.
Issue
No 4 (2022)
Section
Low-molecular weight compounds

Copyright (c) 2022 chemistry of plant raw material

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