SUBCRITICAL WATER AS A TOOL FOR OBTAINING EXTRACTS OF SECONDARY PLANT METABOLITES WITH HIGH ANTIOXIDANT ACTIVITY FROM GINKGO BILOBA L. LEAVES

UDC 542.06.542.93.547.918.615.322.634.572

  • Salima Salimovna Khizrieva Research Institute of Physical and Organic Chemistry, Southern Federal University https://orcid.org/0000-0001-7064-2402 Email: hizrieva@sfedu.ru
  • Sergey Nikolaevich Borisenko Research Institute of Physical and Organic Chemistry, Southern Federal University https://orcid.org/0000-0001-9966-9529 Email: snborisenko@sfedu.ru
  • Yelena Vladimirovna Maksimenko Research Institute of Physical and Organic Chemistry, Southern Federal University https://orcid.org/0000-0002-8715-4517 Email: maksimenkoev52@mail.ru
  • Galina Vladimirovna Zharkova Research Institute of Physical and Organic Chemistry, Southern Federal University Email: galya.zharkova.1999@mail.ru
  • Nikolay Ivanovich Borisenko Research Institute of Physical and Organic Chemistry, Southern Federal University https://orcid.org/0000-0003-4733-1985 Email: niborisenko@sfedu.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20230211437
Keywords: subcritical water, antioxidant activity, ginkgo biloba (Ginkgo biloba), polyphenols, flavonoids, Folin-Chocalteu method, 2,2-diphenyl-1-picrylhydrazyl (DPPH)

Abstract

Extracts of secondary plant metabolites (SPM) with high antioxidant activity (AOA) are gaining more and more attention as biologically active additives. To obtain them, methods of "green chemistry" are increasingly being considered. In the present work, to obtain extracts with high antioxidant activity enriched of polyphenols from the leaves of Ginkgo biloba (GB), medium of a subcritical water (SCW) was used in the temperature range from 100 to 220 °C. The use medium of the SCW for extraction processes allows not only to increase the extraction of SPM from the plant matrix, but also to achieve a change in the phytochemical profile of the obtained extracts.

The polyphenol profile of extracts leaf’s GB was studied by UV/Vis spectrophotometry, as well as the dependence of the content of SPM, in the form of the sum of polyphenolic compounds (including flavonoids) and AOA of extracts, on the extraction method: in medium of SCW or water-alcohol (traditional) extraction. It has been shown that the content of polyphenolic compounds and the AOA of extracts depend on the extraction conditions (temperature of SCW). It was demonstrated that the extract obtained from leaves of GB in SCW at 220 °C contains the highest amount of polyphenolic compounds and demonstrates the maximum AOA (EC50=34.7 μg/ml) among the obtained extracts. The presented results demonstrate the promise of using SCW to obtain extracts from leaves of GB with a high content of polyphenols for the development of pharmaceuticals and food supplements with high AOA.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Salima Salimovna Khizrieva , Research Institute of Physical and Organic Chemistry, Southern Federal University

младший научный сотрудник

Sergey Nikolaevich Borisenko, Research Institute of Physical and Organic Chemistry, Southern Federal University

кандидат химических наук, старший научный сотрудник

Yelena Vladimirovna Maksimenko, Research Institute of Physical and Organic Chemistry, Southern Federal University

научный сотрудник

Galina Vladimirovna Zharkova, Research Institute of Physical and Organic Chemistry, Southern Federal University

магистрант

Nikolay Ivanovich Borisenko , Research Institute of Physical and Organic Chemistry, Southern Federal University

доктор химических наук, главный научный сотрудник

References

Singh S.K., Srivastav S., Castellani R.J., Plascencia-Villa G., Perry G. Neurotherapeutics, 2019, vol. 16, no. 3, pp. 666–674. DOI: 10.1007/s13311-019-00767-8.

Kale M.K., Patil M.P., Bhusari K.P. Research Journal of Pharmacognosy and Phytochemistry, 2011, vol. 3, no. 6, pp. 286–288.

Natarajan S., Shunmugiah K.P., Kasi P.D. Pharmaceutical biology, 2013, vol. 51, no. 4, pp. 492–523. DOI: 10.3109/13880209.2012.738423.

Sasaki K., Wada K., Haga M. Studies in natural products chemistry, 2003, vol. 28, pp. 165–198. DOI: 10.1016/S1572-5995(03)80141-2.

Chan P.C., Xia Q., Fu P.P. Journal of environmental science and health part C, 2007, vol. 25, no. 3, pp. 211–244. DOI: 10.1080/10590500701569414.

Van Beek T.A., Montoro P. Journal of Chromatography A, 2009, vol. 1216, no. 11, pp. 2002–2032. DOI: 10.1016/j.chroma.2009.01.013.

Karayeva A.M., Nartikoyeva M.I., Kabolova M.Z. Vestnik novykh meditsinskikh tekhnologiy, 2020, vol. 27, no. 1, pp. 52–54. DOI: 10.24411/1609-2163-2020-16548. (in Russ.).

Fisher E. Ginkgo biloba: Biology, Uses and Health Benefits. New York: Nova Science Publishers, 2016, 105 p.

Wiesner J., Eibl E-M., Palomino O. Committee on Herbal Medicinal Products (HMPC). Ph. Eur. 7-th edition (7.5), ref. 04/2008:1827. 2012, 116 p.

Vasil'yev V.G., Prokop'yev A.S., Kalabin G.A. Khimiya rastitel'nogo syr'ya, 2016, no. 3, pp. 85–93. DOI: 10.14258/jcprm.2016031234. (in Russ.).

Singh B., Kaur P., Singh R.D., Ahuja P.S. Fitoterapia, 2008, vol. 79, no. 6, pp. 401–418. DOI: 10.1016/j.fitote.2008.05.007.

Kang J.W., Kim J.H., Song K., Kim S.H., Yoon J.H., Kim K.S. Phytotherapy Research, 2010, vol. 24, pp. 77–82. DOI: 10.1002/ptr.2913.

Leistner E., Drewke C. Journal of natural products, 2010, vol. 73, no. 1, pp. 86–92. DOI: 10.1021/np9005019.

Van Beek T.A., Scheeren H.A., Rantio T., Melger W.C., Lelyveld G.P. Journal of Chromatography A, 1991, vol. 543, pp. 375–387. DOI: 10.1016/S0021-9673(01)95789-9.

Ogay M.A., Kovtun Ye.V., Chakhirova A.A., Samoryadova A.B., Bogatyreva Z.N. Nauchnyye rezul'taty biomed-itsinskikh issledovaniy, 2018, vol. 4, no. 2, pp. 90–103. DOI: 10.18413/2313-8955-2018-4-2-0-10. (in Russ.).

Ding X., Ouyang M.A., Liu X., Wang R.Z. Journal of Chemistry, 2013, vol. 2013, article 645086. DOI: 10.1155/2013/645086.

Dhiman P., Malik N., Sobarzo-Sánchez E., Uriarte E., Khatkar A. Molecules, 2019, vol. 24, no. 3, p. 418. DOI: 10.3390/molecules24030418.

Perry E.K., Pickering A.T., Wang W.W., Houghton P., Perry N.S. The Journal of Alternative and Complementary Medicine, 1998, vol. 4, no. 4, pp. 419–428. DOI: 10.1089/acm.1998.4.419.

Yao Z.X., Han Z., Drieu K., Papadopoulos V. The Journal of nutritional biochemistry, 2004, vol. 15, no. 12, pp. 749–756. DOI: 10.1016/j.jnutbio.2004.06.008.

Kakar M.U., Kakar I.U., Mehboob M.Z., Zada S., Soomro H., Umair M., Iqbal I., Umer M., Shaheen S., Syed S.F., Deng Y., Dai R. Carbohydrate Polymers, 2021, vol. 252, 117113. DOI: 10.1016/j.carbpol.2020.117113.

de Mello J.C.P., Valone L. Phytotechnology: A Sustainable Platform for the Development of Herbal Products, 2022, p. 85. DOI: 10.1201/9781003225416-6.

Galkin A.A., Lunin V.V. Uspekhi khimii, 2005, vol. 74, no. 1, pp. 24–40. (in Russ.).

Khizriyeva S.S., Borisenko S.N., Maksimenko Ye.V., Zharkova G.V., Borisenko N.I., Minkin V.I. Sverkhkriticheskiye flyuidy: teoriya i praktika, 2021, vol. 16, no. 4, pp. 70–82. DOI: 10.34984/SCFTP.2021.16.4.007. (in Russ.).

Sinov M.Yu., Shapovalova O.V. Sverkhkriticheskiye flyuidy: teoriya i praktika, 2020, vol. 15, no. 3, pp. 87–102. DOI: 10.34984/SCFTP.2020.15.3.010. (in Russ.).

Khizriyeva S.S., Borisenko N.I. Sverkhkriticheskiye flyuidnyye tekhnologii v reshenii ekologicheskikh problem. [Super-critical fluid technologies in solving environmental problems]. Arkhangel'sk, 2020, vol. 1, pp. 22–26. (in Russ.).

Khizriyeva S.S., Borisenko S.N., Maksimenko Ye.V., Zharkova G.V., Borisenko N.I. Khimiya rastitel'nogo syr'ya, 2022, no. 2, pp. 137–146. DOI: 10.14258/jcprm.20220210519. (in Russ.).

Tutel'yan V.A., Eller K.I., Aleshko-Ozhevskiy Yu.P. Rukovodstvo po metodam kontrolya kachestva i bezopasnosti biologicheski aktivnykh dobavok k pishche. [Guidance on methods of quality control and safety of biologically active food additives]. Moscow, 2004, pp. 124–126. (in Russ.).

Makarova N.V., Zyuzina A.V. Izvestiya vysshikh uchebnykh zavedeniy. Pishchevaya tekhnologiya, 2011, vol. 5-6, pp. 24–25. (in Russ.).

Marchenko M.A., Zilfikarov I.N., Ibragimov T.A., Maleyev A.G. Farmatsiya i farmakologiya, 2017, vol. 5, no. 3, pp. 222–241. DOI: 10.19163/2307-9266-2017-5-3-222-241. (in Russ.).

Khasanov V.V., Ryzhova G.L., Mal'tseva Ye.V. Khimiya rastitel'nogo syr'ya, 2004, no. 3, pp. 63–75. (in Russ.).

Volkov V.A., Pakhomov P.M. Vestnik Tverskogo gosudarstvennogo universiteta. Seriya: Biologiya i ekologiya, 2007, no. 5, pp. 64–67. (in Russ.).

Roche M., Dufour C., Mora N., Dangles O. Organic and biomolecular chemistry, 2005, vol. 3, no. 3, pp. 423–430. DOI: 10.1039/B416101G.

Getachew A.T., Chun B.S. Innovative food science and emerging technologies, 2016, vol. 38, pp. 24–31. DOI: 10.1016/j.ifset.2016.09.006.

Carciochi R.A., Dimitrov K. Journal of food science and technology, 2016, vol. 53, no. 11, pp. 3978–3985. DOI: 10.1007/s13197-016-2393-7.

Guillot F.L., Malnoë A., Stadler R.H. Journal of Agricultural and Food Chemistry, 1996, vol. 44, no. 9, pp. 2503–2510. DOI: 10.1021/jf9508155.

Khuwijitjaru P., Plernjit J., Suaylam B., Samuhaseneetoo S., Pongsawatmanit R., Adachi S. The Canadian Journal of Chemical Engineering, 2014, vol. 92, no. 5, pp. 810–815. DOI: 10.1002/cjce.21898.

Published
2023-06-26
How to Cite
1. Khizrieva S. S., Borisenko S. N., Maksimenko Y. V., Zharkova G. V., Borisenko N. I. SUBCRITICAL WATER AS A TOOL FOR OBTAINING EXTRACTS OF SECONDARY PLANT METABOLITES WITH HIGH ANTIOXIDANT ACTIVITY FROM GINKGO BILOBA L. LEAVES // chemistry of plant raw material, 2023. № 2. P. 241-251. URL: http://journal.asu.ru/cw/article/view/11437.
Issue
No 2 (2023)
Section
Low-molecular weight compounds

Copyright (c) 2023 chemistry of plant raw material

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

The authors, which are published in this journal, agree to the following conditions:

1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .

2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.

3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.