SMALLANTHUS SONCHIFOLIA: USES AND PROSPECTS (A REVIEW)
UDC 615.322
Abstract
This literature review is devoted to the tuberous yacon (Smallanthus sonchifolius), a perennial plant of the family Asteraceae, which is widely used in traditional medicine. Yacon tubers are characterized by a sufficiently high content of inulin for industrial production. The data provided in the review show that Smallanthus sonchifolius has a proven prebiotic effect due to its high content of fructooligosaccharides as well as other chemical compounds and has great potential as a prebiotic. In addition to the prebiotic effect, yacon has a wide range of pharmacological effects, including antidiabetic, hypoglycemic, hypolipidemic, anti-inflammatory, antitumor, immunostimulatory, antioxidant, antidepressant, hepatoprotective, spermatogenic, antibacterial, antifungal, antiparasitic, analgesic. Infusions made from yacon leaves can be not only effective agents against hyperglycemia, but also a relatively rich source of polyphenolic antioxidants. Yacon has potential as a plant supplement to treat male infertility and normalize low testosterone levels, such as in LOH-syndrome. The diversity of pharmacological action of yacon is due to the content of different groups of biologically active substances described in the review. The underground organs, leaves, and flowers of yacon contain various chemical compounds, including phenolic acids, sesquiterpene lactones, fructooligosaccharides of inulin type β (2→1), tannins, flavonoids, saponins, and anthracene derivatives.
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Bostid N.R.C. Yacon Lost crops of the Incas: Little-known plants of the Andes with promise for worldwide cultivation. Washington National Academy Press, 1989, pp. 115–123.
Guluyeva D.T. Otsenka kormovoy tsennosti zelenoy massy i klubney yakona i effektivnost' ikh ispol'zovaniya v korm-lenii sviney: diss. … kand. s-kh. nauk. [Evaluation of the nutritional value of green mass and tubers of yacon and the ef-fectiveness of their use in feeding pigs: diss. … cand. agricultural sciences]. Vladikavkaz, 2016, 170 p. (in Russ.).
Valentova K., Frcek J., Ulrichov J. Chem. Listy, 2001, vol. 95, pp. 594–601.
Aybar M.J., Sánchez R.A.N., Grau A., Sánchez S.S. J. Ethnopharmacol., 2001, vol. 74, pp. 125–132. DOI: 10.1016/S0378-8741(00)00351-2.
Talledo D., Escobar C. Genética de las Células Somáticas de Raíces y Tuberosas Andinas. Raíces Andinas, Manual de Capacitación, Lima: CIP, 2000. Fascículo 7, pp. 1–20.
Itaya N.M., de Carvakho M.A.M., Figueiredo-Ribeiro R.D.L. Physiol. Plant, 2002, vol. 116, pp. 451–459.
Grau A., Rea J. Andean roots and tubers: Ahipa, arracacha, maca and yacon. Rome: IPGRI, 1997, pp. 199–242.
Niwa M., Arai T., Fujita K., Marubachi W., Inoue E., Tsukihashi T. J. Jap. Soc. Hortic. Sci., 2002, vol. 71, pp. 561–567.
Lachman J., Fernández E.C., Orsák M. Plant Soil. Environ., 2003, vol. 49, pp. 283–290.
Bodrug M.V. Vtoroy mezhdunarodnyy simpozium «Novyye i netraditsionnyye rasteniya i perspektivy ikh praktich-eskogo ispol'zovaniya»: materialy dokladov. [Second International Symposium "New and non-traditional plants and prospects for their practical use": materials of reports]. Pushchino, 1997, vol. 4, pp. 286–288. (in Russ.).
Tyukavin G.B. Introduktsiya yakona v Rossii. [Introduction of the yacon in Russia]. Moscow, 2001, 271 p. (in Russ.).
Tyukavin G.B. Selskochozyaystvennaya biologia, 2002, vol. 3, pp. 81–87.
Gins M.S., Gins V.K., Kononkov P.F., Dunich A.A., Dashchenko A.V., Mishchenko L.T. Ovoshchi Rossii, 2015, no. 3 (28), pp. 118–122. DOI: 10.18619/2072-9146-2015-3-4-118-122. (in Russ.).
Lachman J., Hejtmánková A., Dudjak J., Fernández E.C., Pivec V. Content of polyphenolic antioxidants and phenol-carboxylic acids in selected organs of yacon [Smallanthus sonchifolius (Poepp. et Endl.) H. Robinson]. Pardubice: Univerzita Pardubice, 2003, pp. 89–97.
Tsugkiyeva V.B. Izvestiya Gorskogo gosudarstvennogo agrarnogo universiteta, 2011, vol. 48, pp. 117–118. (in Russ.).
Padilla-Gonzalez G.F., Amrehn E., Frey M., Gómez-Zeledón J., Kaa A., da Costa F.D., Spring O. Int. J. Mol. Sci., 2020, vol. 21, 4555. DOI: 10.3390/ijms21124555.
Valentova K., Ulrichova J. Biomedical papers of the Medical Faculty of the University Palacky, 2004, vol. 147(2), pp. 119–130. DOI: 10.5507/bp.2003.017.
Campos D., Betalleluz-Pallardel I., Chirinos R., Aguilar-Galvez A., Noratto G., Pedreschi R. Food Chemistry, 2012, vol. 135, pp. 1592–1599.
Takenaka M., Yan X., Ono H., Mitsuru Y., Nagata T., Nakanishi T. J. Agric. Food Chem., 2003, vol. 51, pp. 793–796.
Oliveira P.M. Avaliação dos efeitos toxicológicos in vitro e neuroprotetores in vivo do extrato hidroalcoólico das folhas e raízes do Yacon (Smallanthus sonchifolius). Uruguaiana, 2019, 126 p.
Kolesnikova Ye.O. Biologicheskiy potentsial i metody sozdaniya iskhodnogo materiala yakona (Polymnia sonchi-folia Poepp. & Endl.) pri introduktsii v TSCHR: diss. … kand. biol. nauk. [Biological potential and methods for creating the source material of yacon (Polymnia sonchi-folia Poepp. & Endl.) when introduced into the Central Chernozem region: diss. … cand. biol. Sciences]. Ramon', 2009, 143 p. (in Russ.).
Demeshko O., Krivoruchko E., Volochai V., Samoilova V., Kovalev V. Ceska Slov Farm., 2020, vol. 69(1), pp. 48–51.
Korenman Ya.I., Rudnichenko Ye.S., Mel'nikova Ye.I., Niftaliyev S.I. Izvestiya VUZov. Pishchevaya tekhnologiya, 2007, no. 5 (6), pp. 56–58. (in Russ.).
Rudnichenko Ye.S., Korenman Ya.I, Mel'nikova Ye.I., Niftaliyev S.I. Khimiya rastitel'nogo syr'ya, 2008, no. 4, pp. 79–82. (in Russ.).
Goto K., Fukai K., Hikida J., Nanjo F., Hara Y. Biosci Biotech Biochem., 1995, vol. 59, pp. 2346–2347.
Kamp L., Hartung J., Mast B., Graeff-Hönninger S. Agronomy, 2019, vol. 9, 301. DOI: 10.3390/agronomy9060301.
Genta S.B., Cabrera W.M., Mercado M.I., Grau A., Catalán C.A, Sánchez S.S. Chem. Biol. Interact., 2010, vol. 185(2), pp. 143–152. DOI: 10.1016/j.cbi.2010.03.004.
Paredes L., Smiderle F.R., Santana-Filho A.P., Kimura A., Iacomini M., Sassaki G. International journal of biological macromolecules, 2018, vol. 108, pp. 1074–1081. DOI: 10.1016/j.ijbiomac.2017.11.034.
Ohyama T., Ito O., Yasuyoshi S., Ikarashi T., Minamisawa K., Kubota M., Tsukihashi T., Asami T. Soil Sci. Plant Nutr., 1990, vol. 36, pp. 167–171.
Lachman J., Havrland B., Fernandez E., Dudjak J. Plant Soil and Environment, 2004, vol. 50 (9), pp. 383–390. DOI: 10.17221/4048-PSE.
Pedreschi R., Campos D., Noratto G., Chirinos G., Cisneros-Zevallos L. J. Agric. Food Chem., 2003, vol. 51, pp. 5278–5284.
Asami T., Minasawa K., Tsuchiya T., Kano K., Hori I., Ohyama T., Kubota M., Tzukihashi T. Jpn. J. Soil Sci. Plant Nutr., 1991, vol. 62, pp. 621–627.
Fukai K., Ohno S., Goto K., Nanjo F., Hara Y. Soil Sci. Plant Nutr., 1997, vol. 43, pp. 171–177.
Tzukihashi T. Kiseki no kenkô jasai jâkon. Kosaido Books, 1999.
Yan X., Suzuki M., Ahnishi-Kameyama M., Sada Y., Nakanishi T., Nagata T. J. Agric. Food Chem., 1999, vol. 47, pp. 4711–4713.
Takenaka M., Ono H. Tetrahedron Lett., 2003, vol. 44, pp. 999–1002.
Simonovska B., Vovk I., Andrenšek S., Valentová K., Ulrichová J. J. Chromatogr A, 2003, vol. 1016, pp. 89–98.
Park J.S., Han K. Biomol. Ther., 2013, vol. 21(2), pp. 153–160. DOI: 10.4062/biomolther.2012.093.
Lee M.K, Kim H.W., Lee S., Asamenew G., Kim Y.J., Suji Lee, Jung H., Yoo S., Kim J.B. Journal of the Korean So-ciety of Food Science and Nutrition, 2018, vol. 47, pp. 1284–1293. DOI: 10.3746/jkfn.2018.47.12.1284.
Vasfilova Ye.S., Bagautdinova R.I., Okoneshnikova T.F. Vestnik Tomskogo gosudarstvennogo universiteta. Biologiya, 2015, no. 2 (30), pp. 96–112. DOI: 10.17223/19988591/30/7. (in Russ.).
Gins M.S., Gins V.K., Kononkov P.F., Dunich A.A., Dashchenko A.V., Mishchenko L.T. Sel'skokhozyaystvennaya biologiya, 2015, vol. 50, no. 5, pp. 628–636. DOI: 10.15389/agrobiology.2015.5.628rus. (in Russ.).
Takasugi M., Masuda T. Phytochemistry, 1996, vol. 43, pp. 1019–1021.
Yoshida M., Ono H., Mori Y., Chuda Y., Mori M. J. Agric. Food Chem., 2002, vol. 50, pp 4377–4381.
Ragasa C.Y., Alimboyoguen A.B., Urbana S., Raga D.D. Natural Product Communications, 2008, vol. 3, no. 10, pp. 1663–1666.
Lolan A.B.W.P. Universitas Katolik Soegijapranata Semarang, 2017, pp. 1–7.
Valentová K., Cvak L., Muck A., Ulrichová J., Šimánek V. Eur. J. Nutr., 2003, vol. 42, pp. 61–66. DOI: 10.1007/s00394-003-0402-x.
Jirovský D., Horáková D., Kotouček M., Valentová K., Ulrichová J. J. Sep. Sci., 2003, vol. 26, pp. 739–742.
Beutler J.A., Cardellina J.H., Lin C.M., Hamel E., Cragg G.M., Boyd M.R. BioMed Chem. Lett., 1993, vol. 3, pp. 581–584.
Barrero A.F., Oltra J.E., Cerdá-Olmedo E., Ávalos J., Justicia J. J. Nat. Prod., 2001, vol. 64, pp. 222–225.
Inoue A., Tamogami S., Kato H., Nakazato Y., Akiyama M., Kodama O., Akatsuka T., Hashidoko Y. Phytochemistry, 1995, vol. 39, pp. 845–848.
Bohlmann F., Knoll K.H., Robinson H., Kong R.M. Phytochemistry, 1980, vol. 19, pp. 107–110.
Bohlmann F., Knoll K.H., Robinson H., Kong R.M. Phytochemistry, 1980, vol. 19, pp. 973–974.
Castro V., Jakupovic J., Dominiguez X.A. Phytochemistry, 1989, vol. 28, pp. 2727–2729.
Ran X., Aung K.K.W., Bai J., Dou P., Zeng Z., Dou D. Journal of Asian Natural Products Research, 2018, vol. 20, pp. 538–544. DOI: 10.1080/10286020.2017.1411346.
Kitai Y., Hayashi K., Otsuka M., Nishiwaki H., Senoo T., Ishii T., Sakane G., Sugiura M., Tamura H. Journal of agri-cultural and food chemistry, 2015, vol. 63, pp. 10856–10861. DOI: 10.1021/acs.jafc.5b05229.
Zheng X., Fan H., Ting-Guo K., De-Qianga D., Kuo G, Yu-Yuan S., Young-Ho K., Feng D. Natural Product Com-munications, 2010, vol. 5, pp. 95–98. DOI: 10.1177/1934578X1000500123.
Sinurat M.R., Rahmayanti Y., Rizarullah R. Jurnal IPA dan Pembelajaran, 2021, vol. 2, pp. 138–150. DOI: 10.24815/JIPI.V5I2.20068.
Svistova I.D., Kuvshinova N.M. Eksperimental'naya mikologiya, 2015, pp. 69–71. (in Russ.).
Andrieux C. Prebiotics and health, 2002.
Mal'tseva T.V. v-fruktozidaza drozhzhey Kluyveromyces marxianus Y-303: preparativnoye polucheniye, svoystva i primeneniye v biotekhnologii: avtoref. diss. … kand. biol. nauk. [β-fructosidase from yeast Kluyveromyces marxianus Y-303: preparative preparation, properties and application in biotechnology: abstract of diss. … cand. biol. Sciences]. Voronezh, 2003. (in Russ.).
Tomayeva Z.R. Biologo-khozyaystvennyye osobennosti yakona v usloviyakh RSO-Alaniya i perspektivy yego ispol'-zovaniya: diss. … kand. biol. nauk. [Biological and economic features of the yacon in the conditions of North Ossetia-Alania and the prospects for its use: diss. … cand. biol. Sciences]. Vladikavkaz, 2006, 141 p. (in Russ.).
Martino H., Kolba N., Tako E. Food Res. Int., 2020, vol. 137, 109705. DOI: 10.1016/J.FOODRES.2020.109705.
Pedreschi R., Campos D., Noratto G., Chirinos R., Cisneros-Zevallos L. J. Agric. Food Chem., 2003, vol. 51, pp. 5279–5283.
Higashimura Y., Hirabayashi M., Nishikawa H., Inoue R., Nagai E., Matsumoto K., Enomoto T., Mizushima K., Tak-agi T., Naito Y. J. Clin. Biochem. Nutr., 2021, vol. 69, pp. 272–279. DOI: 10.3164/jcbn.20-203.
Verediano T., Viana M., Tostes M.G.V., Costa N. Current Nutrition & Food Science, 2021, vol. 17, pp. 167–175. DOI: 10.2174/1573401316999200605160433.
Marques C., Toazza C.E.B., Sari R., Mitterer-Daltoé M., Amaral W., Masson M.L. Food Bioscience, 2021, vol. 41, 100970. DOI: 10.1016/J.FBIO.2021.100970.
Coronado D.A., Salazar M.E. Ciencia E Investigación, 2017, vol. 19 (2), pp. 70–73. DOI: 10.15381/CI.V19I2.13631.
Leone R., de Andrade E.F., Ellendersen L., da Cunha A.T., Martins A.M.C.V., Granato D., Masson M.L. LWT, 2017, vol. 75, pp. 220–226. DOI: 10.1016/J.LWT.2016.08.027.
Marcon L.D.N. Journal of Food Science & Nutrition, 2020, vol. 6, 069. DOI: 10.24966/FSN-1076/100069.
Marcon L.D., Moraes L.F.S., Cruz B.C.S., Teixeira M.D., Bruno T.C.V., Ribeiro I.E., Messias A.C., Ferreira C.L.L., de Oliveira L.D., Pelϊzio M. Journal of Functional Foods, 2019, vol. 55, pp. 333–342. DOI: 10.1016/J.JFF.2019.02.039.
Prado E.C., Purisaca-Salinas P., Moreno-Rojo C., Guillén-Sánchez J. The Journal of medical research, 2020, vol. 20, pp. 1–8. DOI: 10.34257/gjmrlvol20is1pg23.
Rahmaisyah D., Wasityastuti M.M.E.W., Widasari S.P.A.D.I. Kadar interleukin 23 (IL-23) dan profil infiltrasi leu-kosit pada kolon mencit model kolitis hasil induksi TNBS (2.4.6-Trinitrobenzene Sulfonic Acid) yang diberi bubuk umbi yakon (Smallanthus sonchifolius). Universitas Gadjah Mada, 2019.
Tungland B. Human Microbiota in Health and Disease, 2018, pp. 349–379. DOI: 10.1016/B978-0-12-814649-1.00008-9.
Parygina L.A. Priusadebnoye khozyaystvo, 2001, pp. 19–21. (in Russ.).
Podobedov V.I. Moya teplitsa, 2001, no. 6. (in Russ.).
Miura T. Journal of Traditional Medicines, 2007, vol. 24(2), pp. 47–50.
Baroni S., Suzuki-Kemmelmeier F., Caparroz-Assef S.M., Cuman R.K.N., Bersani-Amado C.A. Revista Brasileira de Ciencias Farmaceuticas, 2008, vol. 44(3), pp. 521–530. DOI: 10.1590/S1516-93322008000300024.
Volpato G.T., Vieira F.L., Almeida F.C.G., Camara F., Lemonica I.P. Study of the hypoglycemic effects of Polymnia sonchifolia leaf extracts in rats. Abstracts of the second WOCMAP. Pt. 2. Wageningen, 1999, 319 p.
Dou D.Q., Kang T.G., Qiu Y.K., Tian F. Planta Med., 2008, vol. 74, p. 71. DOI: 10.1055/s-2008-1075267.
Vargas-Tineo O.W., Segura-Muñoz D.M., Becerra-Gutiérrez L.K., Amado-Tineo J.P., Silva-Díaz H. Rev. Peru Med. Exp. Salud. Publica., 2020, vol. 37(3), pp. 478–484. DOI: 10.17843/rpmesp.2020.373.5275.
Ballatong C.F.B., Palayon C.J.B., Peralta Q.V., Ramel F.M.B., Ventura A.M., Carreon J.B. Scientia Naturales, 2016, vol. 3, pp. 91–101.
Lekarstvennoye syr'ye rastitel'nogo i zhivotnogo proiskhozhdeniya. Farmakognoziya: uchebnoye posobiye [Medicinal raw materials of plant and animal origin. Pharmacognosy: textbook], ed. G.P. Yakovlev. St. Petersburg, 2006, 845 p. (in Russ.).
Levinova V.F., Reshetnikova M.D., Khlebnikov A.V. Izbrannyye lektsii po farmakognozii: ucheb. posobiye. [Selected lectures on pharmacognosy: textbook. allowance]. Perm', 2006, 305 p. (in Russ.).
Mitrofanova I.Yu., Yanitskaya A.V. Khimiko-farmatsevticheskiy zhurnal, 2013, vol. 47, no. 3, pp. 45–47. (in Russ.).
Demidova I.YU. Farmateka, 2002, no. 5, рр. 3–8. (in Russ.).
Marchyshyn S.M., Hudzʹ N.A., Krytskaya H.A., Andryyshyn A.P., Tverdokhlyb N.O. Svit medytsyny ta biolohiyi, 2018, no. 2(64), pp. 165–169. (in Russ.).
Mishchenko M.N.L.T. Studia Biologica, 2014, vol. 8(2), pp. 57–64. DOI: 10.30970/sbi.0802.350.
Aziz Z., Yuliana N.D., Simanjuntak P., Rafi M., Mulatsari E., Abdillah S. Plant Foods for Human Nutrition, 2021, vol. 76, pp. 487–493. DOI: 10.1007/s11130-021-00926-3.
Sulastri L., Hidayat R., Citroreksoko P., Abdillah S., Simanjuntak P. Proceeding of Mulawarman Pharmaceuticals Conferences, 2021, pp. 145–152. DOI: 10.25026/mpc.v14i1.563.
Aziz Z., Qisthi F.H.A., Yuliana N.D., Simanjuntak P. Jurnal ilmu kefarmasian Indonesia, 2019, vol. 17, pp. 21–26. DOI: 10.35814/JIFI.V17I1.652.
Dwitiyanti D., Hikmawati N., Putri A.P., Chulsum N. Jurnal tumbuhan obat Indonesia, 2020, vol. 13, pp. 1–8. DOI: 10.22435/JTOI.V13I2.3015.
Mitrofanova I.Y., Yanitskaya A.V. Pharmaceutical Chemistry Journal, 2013, vol. 47(3), pp. 169–171. DOI: 10.1007/ s11094-013-0918-1.
Fayziyeva Z.T. Sibirskiy meditsinskiy zhurnal, 2009, vol. 85, no. 2, pp. 99–100. (in Russ.).
Valentova K., Moncion A., de Waziers I., Ulrichova J. Cell Biol. Toxicol., 2004, vol. 20, pp. 109–120 DOI: 10.1023/B:CBTO.0000027931.88957.80.
Nurmawati T., Arsa S.A.W., Wulandari N., Saparudin A. Jurnal Ners dan Kebidanan, 2021, vol. 8, pp. 219–220.
Nurmawati T., Sari Y.K., Ningtyas F.A. Biosantropis, 2021, vol. 7, pp. 56–62. DOI: 10.33474/E-JBST.V7I1.393.
Putra D., Manalu J.L. Damianus: Journal of Medicine, 2020, vol. 19. DOI:10.25170/djm.v19i2.1141
Aziz Z., Tamara N., Wahyuni R., Abdillah S. African Journal of Pharmacy and Pharmacology, 2019, vol. 13(9), pp. 113–117. DOI: 10.5897/AJPP2019.5023.
Nurmawati T., Rahmawati A., Mutiara F. Biosaintropis, 2022, vol. 7, pp. 105–112. DOI: 10.33474/e-jbst.v7i2.48.
Saputri S., Desi A. Aktivitas antibakteri, antidiabetes dan penyembuhan ulkus diabetik ekstrak etanol daun insulin (Smallanthus sonchifolius). Universitas Setia Budi, 2018.
Oliveira P.M., Maurer P., Pilar B.C. Diabetol Metab Syndr, 2015, vol. 7, 64. DOI: 10.1186/1758-5996-7-S1-A64.
Bork P.M., Schmitz M.L., Kuhnt M., Esher C., Heindrich M. Febs Lett., 1997, vol. 402, pp. 85–90.
Baek S., Choi N., Lee K., Jhun H., Kim J. Journal of Exercise Nutrition & Biochemistry, 2018, vol. 22(2), pp. 031–035. DOI: 10.20463/jenb.2018.0014.
Myint P., Dao T.T.P., Kim Y.S. Molecules, 2019, vol. 24, 3054. DOI: 10.3390/molecules24173054.
Imanuel L.K., Sunarni T., Herdwiani W. Journal of Pharmaceutical Science and Clinical Research, 2021, vol. 6, pp. 74–81. DOI: 10.20961/JPSCR.V6I1.39540.
Mendoza R., Warren S., Vidar G. Journal of Medicinal Plants Research, 2017, vol. 11(10), pp. 207–217. DOI: 10.5897/JMPR2016.6205.
Kitai Y., Zhang X., Hayashida Y., Kakehi Y., Tamura H. J. Food Drug Anal., 2017, vol. 25(3), pp. 619–627. DOI: 10.1016/j.jfda.2016.10.005.
Burick J., Quick H., Wilson T. Provizor, 1998, no. 4. URL: http://www.provisor.com.ua/archive/1998/N4/ekhinac.php?part_code=8. (in Russ.).
Mertens G. Finacial Times Business, 2000, pp. 317–322.
Lachman J., Fernandez E.C., Viehmannova I., Sulc M., Eepkova P. New Zealand Journal of Crop and Horticultural Science, 2007, vol. 35(1), pp. 117–123. DOI: 10.1080/01140670709510175.
Chekmarev P.A., Kononkov P.F., Gins V.K., Goryunova Yu.D. Rol' fiziologii i biokhimii v introduktsii i selektsii ovoshchnykh, plodovo-yagodnykh i lekarstvennykh rasteniy, 2011, pp. 350–352. (in Russ.).
Lebeda A., Dolezalova I., Fernandez E., Viehmannova I. Medicinal Plants, 2012, vol. 6, pp. 641–702.
Naimah S.Y., Cicilia S. Pro Food (Jurnal Ilmu dan Teknologi Pangan), 2020, vol. 6, pp. 742–748. DOI: 10.29303/PROFOOD.V6I2.143
Rudnichenko Ye.S., Korenman Ya.I. Vestnik VGUIT, 2012, no. 2, pp. 138–140. (in Russ.).
Sugahara S., Ueda Y., Fukuhara K., Kamamuta Y., Matsuda Y., Murata T., Kuroda Y., Kabata K., Ono M., Igoshi K., Yasuda S. Journal of food science, 2015, vol. 80(11), pp. 2420–2429. DOI: 10.1111/1750-3841.13092.
Sousa S., Pinto J., Rodrigues C., Gião M., Pereira C., Tavaria F., Malcata F., Gomes A., Pacheco M.T.B., Pintado M. Food Chem., 2015, vol. 188, pp. 504–509. DOI: 10.3136/FSTR.21.255.
Wosko S., Serefko A., Szopa A., Kardas S., Widelski J., Mroczek T., Rostkowska E., Jolanta Szymanska J., Poleszak E. Life, 2021, vol. 11, 1117, pp. 1–13. DOI: 10.3390/life11111117.
Aleman M., Sánchez S., Honoré S. Asian Pacific Journal of Tropical Biomedicine, 2019, vol. 9(9), pp. 365–372. DOI: 10.4103/2221-1691.267637.
Yana E.F., Budijastuti W. LenteraBio: Berkala Ilmiah Biologi, 2022, vol. 11, pp. 202–207. DOI: 10.26740/lenterabio.v11n1.
Agustin C.D. Universitas Airlangga, 2018, pp. 18–166.
Lin F., Hasegawa M., Kodama O. Biosci Biotechnol Biochem., 2003, vol. 67, pp. 2154–2159.
Vieira P.R.N., Reis D.R.M.L. Revista Fitos, 2021, vol. 15(1), pp. 108–114. DOI: 10.32712/2446-4775.2021.864.
Lopes A.A., Pina E.S., Nader T.T., Da Costa F.B., Pereira A.M.S., Pupo M.T. Phytochemistry Letters, 2016, vol. 18, pp. 162–167. DOI: 10.1016/j.phytol.2016.10.011.
Ulloa J., Spina R., Casasco A., Petray P., Martino V., Sosa M., Frank F., Muschietti L. Parasites & Vectors, 2017, vol. 10, 567. DOI: 10.1186/s13071-017-2509-6.
da Silva J.R., Reis K.M.N., de Freitas M.L.F., Ferreira C.L.L.F. Semina-ciencias Agrarias, 2021, vol. 42. DOI: 10.5433/1679-0367.2021V42N1P37.
Durães G.C.S., Pires B., Lins T. Food Research, 2021, vol. 5 (4), pp. 66–71. DOI: 10.26656/fr.2017.5(4).703.
Lancetti R., Palavecino P.M., Bustos M.C., León A.E. LWT, 2020, vol. 125. DOI: 10.1016/j.lwt.2020.109217.
Honoré S., Grande M.V., Rojas J.G., Sánchez S. Journal of Obesity, 2018, pp. 1–15. DOI: 10.1155/2018/5341384.
Martinez-Oliveira P., Zuravski L., de Oliveira M.F., Ströher D., Coelho R.P., Pilar B., de Oliveira L.F.D., Piccoli J., Machado M., Denardin C., Manfredini V. J. Med. Food, 2021, vol. 24(6), pp. 660–665. DOI: 10.1089/jmf.2020.0131.
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