COMPOSITION OF LIPOPHILIC COMPONENTS OF RHODODENDRON ADAMSAY ETHER EXTRACT AND AC-TIVITY AGAINST SARS-COV-2 MAIN PROTEASE
UDC 547.9:582.284.5
Abstract
The composition of the lipophilic components of the Adams rhododendron RhododendronadamsiiRehd. Acid and neutral components were identified using gas-liquid chromatography with mass spectrometric detection. Methyl tert-butyl ether (MTBE), which has all the advantages of diethyl ether, but is devoid of its disadvantages, was used as the raw material extractant. It does not form peroxides and does not create increased gas contamination due to its higher boiling point. As a result, comparison with databases identified triterpene, phenolcarboxylic and aliphatic acids with a chain length of 8 to 30 carbon atoms, including saturated, unsaturated and dibasic acids. More than 150 triterpene and aliphatic components of the unsaponifiable residue and acid fractions have been identified. Previously, unsaponifiable residues of lipophilic extracts were practically not studied. Only components of Rh.adamsiiand other species of the genus rhododendron essential oils have been studied in detail. For bioactivity testing, samples of the whole extract and its fractionation products were prepared. Some of the studied samples show inhibitory activity against the main protease of SARS-CoV-2.
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Dikorastushchiye poleznyye rasteniya flory Mongol'skoy Narodnoy Respubliki. [Wild useful plants of the flora of the Mongolian People's Republic]. Leningrad, 1985, 236 p. (in Russ.).
Budantsev A.L., Lesiovskaya Ye.Ye. Dikorastushchiye poleznyye rasteniya Rossii. [Wild useful plants of Russia]. St. Petersburg, 2001, 663 p. (in Russ.).
Morozova Yu.A., Subotyalov M.A. Rastitel'nyye resursy, 2018, vol. 54, no. 3, pp. 347–360. (in Russ.).
Gubich O.I., Puchkova K.V., Zalesskaya N.A., Kryuchkova N.V. Zhurnal Belorusskogo gosudarstvennogo universiteta. Biologiya, 2018, no. 1, pp. 60 – 68. (in Russ.).
Rastitel'nyye resursy Rossii: Dikorastushchiye tsvetkovyye rasteniya, ikh komponentnyy sostav i biologicheskaya ak-tivnost'. T. 2. Semeystvo Actinidiaceae – Malvaceae, Euphorbiaceae – Haloragaceae [Plant resources of Russia: Wild flowering plants, their composition and biological activity. Vol. 2. Family Actinidiaceae - Malvaceae, Euphorbiaceae - Haloragaceae], ed. A.L. Budantsev. St. Petersburg, Moscow, 2009, 513 p. (in Russ.).
Rogachev A.D., Fomenko V.V., Sal’nikova O.I., Pokrovskii L.M., Salakhutdinov N.F. Chemistry of Natural Com-pounds, 2006, vol. 42, no. 4, pp. 426–430. DOI: 10.1007/s10600-006-0172-9.
Belousov M.V., Basova Ye.V., Yusubov M.S., Berezovskaya T.P., Pokrovskiy L.M., Tkachev A.V. Khimiya rastitel'nogo syr'ya, 2000, no. 3, pp. 45–64. (in Russ.).
Belousov M.V., Dembitskiy A.D., Berezovskaya T.P., Tikhonov V.N. Rastitel'nyye resursy, 1995, vol. 31, no. 4, pp. 41–44. (in Russ.).
Mirovich V.M., Konenkina T.A., Fedoseyeva G.M. Sibirskiy meditsinskiy zhurnal, 2008, vol. 76, no. 1, pp. 79–82. (in Russ.).
Belova N.V. Chemistry of Natural Compounds, 1970, vol. 6, pp. 403–401. DOI: 10.1007/BF00567356.
Belova N.V. Rastitel'nyye resursy, 1971, vol. 7, no. 4, pp. 574–576. (in Russ.).
Rogachev A.D., Morozov S.V., Vyalkov A.I., Fomenko V.V., Salakhutdinov N.F. Khimiya v interesakh ustoychivogo razvitiya, 2007, vol. 15, no. 5, pp. 575–579. (in Russ.).
Fokina G.A. Chemistry of Natural Compounds, 1979, vol. 15, no. 5, pp. 651–652.
Rogachev A.D., Komarova N.I., Morozov S.V., Fomenko V.V., Salakhutdinov N.F. Khimiya v interesakh ustoychivogo razvitiya, 2007, vol. 15, no. 5, pp. 571–574. (in Russ.).
Fokina G.A., Belova N.V. Chemistry of Natural Compounds, 1974, vol. 10, no. 6, pp. 827–828. DOI: 10.1007/BF00564024.
Mirovich V.M., Makarenko S.P., Paisova O.I. Byulleten' VSNTS SO RAMN, 2005, vol. 45, no. 7, pp. 164–166. (in Russ.).
Komarova N.I., Rogachev A.D., Chernyak E.I., Morozov S.V., Fomenko V.V., Salakhutdinov N.F. Chemistry of Natural Compounds, 2009, vol. 45, no. 1, pp. 27–31. DOI: 10.1007/s10600-009-9215-3.
Razgonova M., Zakharenko A., Ercisli S., Grudev V., Golokhvast K. Molecules, 2020, vol. 25, 3774. DOI: 10.3390/molecules25173774.
Rogachev A.D., Komarova N.I., Korchagina D.V., Dolgikh M.P., Sorokina I.V., Bayev D.S., Tolstikova T.G., Fomenko V.V., Salakhutdinov N.F. Khimiya v interesakh ustoychivogo razvitiya, 2009, vol. 17, no. 2, pp. 191–198. (in Russ.).
Olennikov D.N., Nikolaev V.M., Chirikova N.K. Antioxidants, 2021, vol. 10, no. 6, p. 863. DOI: 10.3390/antiox10060863.
Kukina T.P., Frolova T.S., Salnikova O.I. Chemistry of Natural Compounds, 2014, vol. 50, no. 2, pp. 233–236. DOI: 10.1007/s10600-014-0920-1.
Kukina T.P., Shcherbakov D.N., Gensh K.V., Tulysheva E.A., Salnikova O.I., Grazhdannikov A.E., Kolosova E.A. Russian Journal of Bioorganic Chemistry, 2017, vol. 43, no. 7, pp. 57–61. DOI: 10.1134/S1068162017070093.
Kukina T.P., Shcherbakov D.N., Gensh K.V., Panteleeva N.V., Tulysheva E.A., Salnikova O.I., Grazhdannikov A.E., Kolosov P.V., Galitsyn G.Yu. Russian Journal of Bioorganic Chemistry, 2020, vol. 46, no. 7, pp. 1372–1377. DOI: 10.1134/S1068162020070067.
Kukina T.P., Shcherbakov D.N., Zybkina A.V., Yelshin I.A., Korsakov V.O., Sal'nikova O.I., Kolosov P.V., Sandag Ts., Karakay D.A., Mordvinova Ye.D. Khimiya rastitel'nogo syr'ya, 2021, no. 4, pp. 307–317. (in Russ.).
Shcherbakov D., Baev D., Kalinin M., Dalinger A., Chirkova V., Belenkaya S., Vatsadze S. ACS medicinal chemistry letters, 2021, vol. 13, no. 1, pp. 140–147.
Jin Z., Du X., Xu Y., Deng Y., Liu M., Zhao Y., Zhang B., Li X., Zhang L., Peng C., Duan Y., Yu J., Wang L., Yang K., Liu F., Jiang R., Yang X., You T., Liu X., Yang X., Bai F., Liu H., Liu X., Guddat L.W., Xu W., Xiao G., Qin C., Shi Z., Jiang H., Rao Z., Yang H. Nature, 2020, vol. 582, no. 7811, pp. 289–293.
Ma C., Hu Y., Townsend J.A., Lagarias P.I., Marty M.T., Kolocouris A., Wang J. ACS Pharmacol. Transl. Sci., 2020, vol. 3, no. 6, pp. 1265–1277.
Kashiwada Y., Yamazaki K., Ikeshiro Y., Yamagishi T., Fujioka T., Mihashi K., Lee K.H. Tetrahedron, 2001, vol. 57, no. 8, pp. 1559–1563.
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