INVESTIGATION OF CELANDINE EXTRACTS (CHELIDONIUM MAJUS L.) BY 1H NMR AND QNMR METHODS

UDC 543.429.23:582.682.4:547.94

  • Mikhail Olegovich Korotkikh N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS
  • Elena Petrovna Romanenko N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS Email: roman@nioch.nsc.ru
  • Vera Dmitriyevna Tikhova N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS Email: tikhova@nioch.nsc.ru
  • Aleksej Vasil'evich Tkachev N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS http://orcid.org/0000-0002-6310-0936 Email: atkachev@nioch.nsc.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20230111663
Keywords: celandine, Chelidonium majus alkaloids, State Pharmacopoeia of the Russian Federation, NMR profiling

Abstract

The analysis of Celandine extracts (Chelidonium majus L.) by 1H NMR method makes it possible to identify the main alkaloids – derivatives of phenanthridine, protoberberin and protopin, and the use of the qNMR method provides information with satisfactory accuracy about the content of these alkaloids. The content of alkaloids determined in the composition of Celandine extracts by the qNMR method (0.35%) is 2 times lower than when using the spectrophotometric determination procedure described in the GF of the Russian Federation XIV (0.72%). The extraction results according to the methods given in the State Pharmacopoeia of the Russian Federation of the XIV edition and in the State Pharmacopoeia of the USSR of the IX edition give similar results: the same alkaloids are found in the extracts – chelidonin, stylopine and protopine, and the total content of alkaloids is 1.6-1.8 times less than when extracting the same raw material samples by the method insistence. When extracted by infusion, the main alkaloids in the extracts are dihydrosanguinarin, chelidonin, stylopine, berberine and coptisin.

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Author Biographies

Mikhail Olegovich Korotkikh, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS

аспирант

Elena Petrovna Romanenko, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS

ведущий инженер

Vera Dmitriyevna Tikhova, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS

кандидат химических наук, заведующая лабораторией

Aleksej Vasil'evich Tkachev, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of SB RAS

доктор химических наук, заведующий лабораторией

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Published
2023-03-13
How to Cite
1. Korotkikh M. O., Romanenko E. P., Tikhova V. D., Tkachev A. V. INVESTIGATION OF CELANDINE EXTRACTS (CHELIDONIUM MAJUS L.) BY 1H NMR AND QNMR METHODS // chemistry of plant raw material, 2023. № 1. P. 101-114. URL: http://journal.asu.ru/cw/article/view/11663.
Issue
No 1 (2023)
Section
Low-molecular weight compounds

Copyright (c) 2023 chemistry of plant raw material

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