TECHNOLOGY OF OBTAINING DRY EXTRACTS FROM HERBAL MIXTURES
UDC 615.262.1
Abstract
In modern medical practice, a special place is occupied by herbal mixtures, the range of which is constantly increasing, and the list of indications for use is expanding. However, there are a number of inconveniences for patients when using them: the presence of an additional technological stage for obtaining an aqueous extract; lack of accuracy when dosing this form and a short shelf life at home. All this makes the search for new, more rational dosage forms based on fees relevant. Such dosage forms include dry extracts, which are obtained on an industrial scale. This type of total preparations can be used as an intermediate in the preparation of finished dosage forms (tablets, capsules, etc.), which are easy to use, well dosed and have a long shelf life. Purpose: development of technology for obtaining dry extracts from herbal mixtures - urological, nephrolytic and hypoglycemic. Materials and methods. Based on the use of medicinal plants in folk and scientific medicine, various compositions of herbal mixtures have been developed. On the basis of pharmacological screening, the most effective formulations were selected, which were chosen as objects of study: "Urological collection"; "Nephrolytic collection"; "Hypoglycemic collection". When obtaining dry extracts, the methods of maceration and repercolation were used. The quality of the obtained extracts was assessed according to the following indicators: appearance, authenticity, moisture content, heavy metals, microbiological purity, quantitative content of biologically active substances (polyphenolic compounds and polysaccharides). The technological parameters of the studied phytocompositions have been established. The optimal extraction conditions were determined: raw material fineness – 2–3 mm, extractants: 50% ethyl alcohol (“Urological”) and purified water (“Hypoglycemic” and “Nephrolytic”), the optimal ratio of raw materials and extractant is 1 : 30, temperature – 70–80 °С ("Urological" and "Nephrolytic") and 90–100 °С ("Hypoglycemic"). The optimal method for obtaining dry extracts from herbal mixtures, maceration, was experimentally selected. A technology for obtaining dry extracts from herbal mixtures has been developed, in particular, the influence of extraction conditions depending on temperature, the degree of grinding of raw materials, the type of extractant, the ratio of raw materials and extractant has been studied.
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Samylina I.A., Sorokina A.A., Pyatigorskaya N.V. Farmateka, 2010, no. 10, pp. 80–82. (in Russ.).
Dzhamshedov Dzh.N., Rakhimov I.F., Khaydarov K., Izzatulloyev A.S., Musozoda S.M., Shpichak O.S. Nauka i in-novatsiya, 2018, no. 2, pp. 105–108. (in Russ.).
Khishova O.M. Vestnik farmatsii, 2004, no. 2 (24), pp. 21–25. (in Russ.).
Gosudarstvennaya farmakopeya Respubliki Uzbekistan. [State Pharmacopoeia of the Republic of Uzbekistan]. Tashkent, 2021, vol. 1-2. (in Russ.).
VFS 42 Uz-0266-20. Tsvetki tysyachelistnika tavolgolistnogo. [VFS 42 Uz-0266-20. Flowers of yarrow]. (in Russ.).
VFS 42 Uz-0334-2007. Trava zizifory tsvetonozhechnoy. [VFS 42 Uz-0334-2007. Jujube herb]. (in Russ.).
GOST 976251. List shelkovitsy beloy. [GOST 976251. White mulberry leaf]. (in Russ.).
Gosudarstvennaya farmakopeya Rossiyskoy Federatsii XIV izdaniya. [State Pharmacopoeia of the Russian Federation XIV edition]. Moscow, 2018, vol. 3, 1294 p. (in Russ.).
Shulepova I.I. Farmakognoziya: uchebnoye posobiye. [Pharmacognosy: textbook.]. Ussuriysk, 2016, pp. 38–40. (in Russ.).
Savchenko L.N., Marinina T.F., Karpenko V.A., Saushkina A.S. Razrabotka tekhnologii i analiza ekstrakta zhidkogo iz list'yev i tsvetkov kashtana konskogo obyknovennogo v kachestve protivovospalitel'nogo i venotoniruyushchego sredstva. [Development of technology and analysis of a liquid extract from the leaves and flowers of horse chestnut as an anti-inflammatory and venotonic agent]. 2015, pp. 612–617. (in Russ.).
Fedoseyeva L.M., Chistova Yu.I. Byulleten' meditsinskoy nauki, 2018, no. 2, pp. 37–41. (in Russ.).
Gosudarstvennaya farmakopeya Rossiyskoy Federatsii XIV izdaniya. [State Pharmacopoeia of the Russian Federation XIV edition]. Moscow, 2018, vol. 2, 1980 p. (in Russ.).
Chuyeshov, V.I., Gladukh, Ye.V. Tekhnologiya lekarstv promyshlennogo proizvodstva. [Industrial drug technology]. 2014, pp. 403–445. (in Russ.).
Alekseyev K.V., Kedik S.A., Blynskaya Ye.V., Alekseyev V.K., Maslennikova N.V. Farmatsevticheskaya tekhnologi-ya. [Pharmaceutical technology]. Moscow, 2015, 672 p. (in Russ.).
Zhumakanova B.S., Orazaliyeva M., Kesikova A.A., Ibadullayeva G.S., Sakipova Z.B. Vestnik KazNMU, 2018, no. 4, pp. 163–166. (in Russ.).
Suina I.O., Terninko I.I. Razrabotka i registratsiya lekarstvennykh sredstv, 2017, no. 4 (21), pp. 202–205. (in Russ.).
Zhumashova G.T., Sayakova G.M., Gemedzhiyeva N.G., Bekezhanova T.S. Vestnik KazNMU, 2016, no. 1, pp. 531–534. (in Russ.).
Farmanova N.T., Aliyev Kh.U., Urmanova F.F. Tezisy dokladov XIII nauchnogo Rossiyskogo natsional'nogo kongressa «Chelovek i lekarstvo». [Abstracts of the XIII Scientific Russian National Congress “Man and Medicine”]. Moscow, 2006, p. 599. (in Russ.).
Farmanova N.T., Aliyev Kh.U., Urmanova F.F. Farmatsevticheskiy zhurnal, 2009, no. 2, pp. 68–70. (in Russ.).
Farmanova N.T., Farmanova Sh.I., Kadirov Z.I. Austrian Journal of Technical and Natural Sciences, 2017, vol. 3-4, pp. 37–41.
Malikova G.Yu., Juraeva A.A., Farmanova N.T., Maksudova A.N. Azizov Sh.I. O'zbekiston farmatsevtik xabarno-masi, 2014, no. 3, pp. 48–52. (in Uzb.).
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