TECHNOLOGY OF OBTAINING THE SUM OF IRIDOIDS FROM THE WASTE PROCESSING THE AERIAL PART OF AJUGA TURKESTANICA
UDC 547.672. 633.511:631.8
Abstract
The processes studied of sedimentation and purification of the number of iridoids from the processing waste of the aerial part of Ajuga turkestanica Regel. Brig. (Turkestan tenacious). Based on the results of the research, it was found that for the effective precipitation of iridoids, the ethanol extract from the aerial part of the Turkestan tenacious is concentrated, diluted with water, treated successively with extraction gasoline and ethyl acetate, from the purified solution iridoids and ecdysteroids, are extracted with n-butanol, then the n-butanol extract is concentrated to 1/10 of the initial volume, after which the iridoids are precipitated, by pouring acetone in a volume ratio of n-butanol-acetone 1 : 5, the precipitate is separated and dried. To clean accompanying substances, the dried amount of iridoids is dissolved in ethyl alcohol and re-precipitated by pouring ethyl acetate in a volume ratio of ethyl alcohol-ethyl acetate 1 : 5. Experiments were carried out on the selection of the type of drying apparatus and the establishment of optimal drying conditions. It was revealed that drying the sum of iridoids from the aerial part of the Turkestan tenacious in the "ZPG 150" spray dryer is more optimal than drying in a drying cupboard (vacuum and without vacuum) and an infrared drying cupboard. At the same time, for drying in the "ZPG 150" spray dryer, the dried aqueous solution of iridoids must be prepared as follows: after the second precipitation, the sum of iridoids is dissolved with water until about 7% of the dry residue in the solution is formed and, with the aim of removing residual organic solvents, the aqueous solution of iridoids is concentrated to the content of not more than 15% and not less than 10% of the dry residue. It has been established that to obtain a finished product that is stable in yield and quality, drying an aqueous solution of iridoids in a spray dryer "ZPG 150" must be carried out implemented at a temperature coolant at the inlet 170 °С, at an outlet of 80 °C and a solution feed rate of 80 l/h, spray head rotation speed 8000 rpm and coolant speed 2200 kg/h. Technology has been developed for the production of the substance of iridoids from the waste products of the production of ekdisten from the aerial part of Turkestan tenacious, which allows the rational use of plant raw materials. Approbation of the developed technology showed that the yield of the target product is 1.5% by weight of the raw material.
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Tundis R., Loizzo R.M., Menichini F., Statti A. Mini-Reviews in Medicinal Chemistry, 2008, vol. 8, pp. 399–420. DOI: 10.2174/138955708783955926.
Muhamad Fadzil N.S., Sekar M., Gan S.H., Bonam S.R., Wu Y.S., Vaijanathappa J., Ravi S., Lum P.T., Dhadde S.B. Drug Design, Development and Therapy. 2021, vol. 15, pp. 2721–2746. DOI: 10.2147/DDDT.S299753.
Shabi M.M., Uthrapathy S., Raj C.D., Krishnamoorthy G., Ravindhran D., Joseph J., Rajamanickam V.G. Advances in Bioscience and Biotechnology, 2014, vol. 5, pp. 1018–1024. DOI: 10.4236/abb.2014.513116.
Vaidya H.B., Rajani M., Sudarsanam V., Padh H., Goyal R.K. European journal of pharmacology, 2009, vol. 617 (1-3), pp. 108–112. DOI: 10.1016/j.ejphar.2009.06.053.
Usmanov D.A., Yusupova U.Yu., Syrov V.N., Ramazonov N.Sh., Rasulev B. Natural Product Research, 2021, vol. 35, pp. 2449–2453. DOI: 10.1080/14786419.2019.1677650.
Usmanov D., Ramazanov N.Sh., Yusupova U., Kucherbayev K.Dzh. News of the Academy of sciences of the Republic of Kazakhstan, serieschemistry and technology, 2019, vol. 6, pp. 49–54. DOI: 10.32014/2019.2518-1491.73.
Usmanov D., Azamatov A., Baykuziyev T., Yusupova U., Rasulev B. Natural product research, 2023, vol. 37, pp. 1709–1713. DOI: 10.1080/14786419.2022.2104274.
Modaressi M., Delazar A., Nazemiyeh H., Fathi-Azad F., Smith E., Rahman M.M., Gibbons S., Nahar L., Sarker S.D. Phytotherapy research, 2009, vol. 23(1), pp. 99–103. DOI: 10.1002/ptr.2568.
Zhang H., Rothwangl K., Mesecar A.D., Sabahi A., Rong L., Fong H.H. Journal of Natural Products, 2009, vol. 72(12), pp. 2158–2162. DOI: 10.1021/np900549e.
Chen J.L., Blanc P., Stoddart C.A., Bogan M., Rozhon E.J., Parkeinson N., Ye Z., Cooper R., Balick M., Nana-korn W., Kernan M.R. Journal of Natural Products, 1998, vol. 61, pp. 1295–1297. DOI: 10.1021/np980086y.
Ghule B.V., Yeole P.G. Journal of Ethnopharmacology, 2012, vol. 141, pp. 424–431. DOI: 10.1016/j.jep.2012.03.005.
Wojtyniak K., Szymański M., Matławska I. Phytotherapy research, 2013, vol. 27, pp. 1115–1120. DOI: 10.1002/ptr.4850.
Zvezdina Е.V., Dayronas J.V., Bochkareva I.I., Zilfikarov I.N., Babaeva E.Yu., Ferubko E.V., Guseynova Z.A., Serebryanaya F.K., Kaibova S.R., Ibragimov T.A. Pharmacy & Pharmacology, 2020, vol. 8, pp. 4–28. DOI: 10.19163/2307-9266-2020-8-1-4-28.
Cavchenko V.N. Farmakologicheskoye issledovaniye stakhiridina – preparata, poluchennogo iz chistetsa vzdutogo: avtoref. dis. … kand. med. nauk. [Pharmacological study of stachiridine, a drug obtained from the swollen plant: ab-stract. dis. ...cand. medical sciences]. Moscow, 1977, 18 p. (in Russ.).
Kotenko L.D., Yakubova M.R., Mamatkhanov A.U., Saatov Z., Turakhozhaev M.T. Chemistry of Natural Com-pounds, 2093, vol. 29, pр. 606–607. DOI: 10.1007/BF00630207.
Takasaki M., Yamauchi I.I., Haruna M., Konoshima T. Journal of Natural Products, 1998, vol. 61(9), pp. 1105–1109. DOI: 10.1021/np980148k.
Takasaki M., Tokuda H., Nishino H., Konoshima T. Journal of Natural Products, 1999, vol. 62(7), pp. 972–975. DOI: 10.1021/np990033w.
Konoshima T., Takasaki M., Tokuda H., Nishino H. Cancer Letters, 2000, vol. 157, pp. 87–92. DOI: 10.1016/s0304-3835(00)00479-1.
McLeod D.W., Revell P., Robinson B.V. British journal of pharmacology, 1979, vol. 66(1), pp. 140–141.
Whitehouse L.W., Znamirowska M., Paul C.J. Canadian Medical Association journal, 1983, vol. 129(3), pp. 249–251.
Saatov Z. Ekdisteroidy rasteniy semeystva Caryfilaceae, Labiatae, Compositae: dis. … dokt. khim. nauk. [Ecdysteroids of plants of the family Caryfilaceae, Labiatae, Compositae: dis. ... doc. chem. Sci.]. Tashkent, 1993, 254 p. (in Russ.).
Patent 954 (UZ). 2008. (in Russ.).
Mamatkhanov A.U., Khazhibayev T.A., Khalilov R.M. Khimiya rastitel'nogo syr'ya, 2022, no. 1, pp. 309–318. DOI: 10.14258/jcprm.2022019271. (in Russ.).
Akhnazarova S.L., Kafarov V.V. Optimizatsiya eksperimenta v khimii i khimicheskoy tekhnologii. [Optimization of ex-periments in chemistry and chemical technology]. Moscow, 1978, 319 p. (in Russ.).
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