COMPLEXES OF WATER-SOLUBLE LOCAL PLANT POLYPHENOL DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

UDC 547.562.1.+615:

  • Kuralbay Zhadigerovich Rezhepov A.S. Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences https://orcid.org/0000-0003-2349-9070 Email: r_k_zh@bk.ru
  • Shiyrin Bekniyaz kizi Alimbayeva A.S. Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences Email: r_k_zh@bk.ru
Keywords: gossypol, Schiff bases, azo derivatives of gossypol, iminoazo derivatives of gossypol, poly-N-vinylpyrrolidone, UV and IR spectroscopy methods, interferon-inducing activity

Abstract

The article is devoted to obtaining water-soluble complexes of iminoazo derivatives of gossypol, studying their physicochemical properties and biological activity. Aromatic, heterocyclic amines and sulfanilamide preparations were used as amine components in obtaining iminoazo derivatives of gossypol and their water-soluble complexes. The maximum values of wavelengths and the corresponding optical densities were determined in the UV spectra of compounds in acetone solvent. In order to determine the structure of the compounds, the infrared spectrum was taken and analyzed: the shift of the fundamental vibrational frequencies up to 31 cm-1 showed that the water-poly-N-vinylpyrrolidone in the compound is connected to a lesser extent as a result of hydrogen bonding. Obtaining complexes of azoderivatives of gossypol imines with poly-N-vinylpyrrolidone is related to the multi-functionality of the reactive groups of the ligand compound; formed hydrogen bonds due to the oxygen of the cycloamide group. For the first time, six new water-soluble complexes iminoazo derivatives of gossypol with poly-N-vinylpyrrolidone were obtained. The results of determination of interferon-inducing activity of compounds were analyzed. The activity was compared with the effectiveness of azo-, iminoazo derivatives of gossypol. According to the obtained results, it was shown that the effectiveness of water-soluble complexes iminoazo derivatives of gossypol.

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Author Biographies

Kuralbay Zhadigerovich Rezhepov, A.S. Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences

Candidate of Chemical Sciences, Senior Researcher, Laboratories of low molecular weight biologically active compounds

Shiyrin Bekniyaz kizi Alimbayeva , A.S. Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences

research intern

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Published
2024-02-15
How to Cite
1. Rezhepov K. Z., Alimbayeva S. B. kizi COMPLEXES OF WATER-SOLUBLE LOCAL PLANT POLYPHENOL DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY // chemistry of plant raw material, 2024. № 1. P. 162-169. URL: http://journal.asu.ru/cw/article/view/12023.
Section
Low-molecular weight compounds