DEVELOPMENT OF A TECHNOLOGICAL SCHEME FOR THE PREPARATION COMPLEX OF ZINC WITH DIHY-DROQUERCETIN
Abstract
The urgency of developing the technology for obtaining a complex of zinc with Dihydroquercetin is due to the revealed high antiradical, antioxidant, antiviral activity of the complex compound and wound healing effect of the original pharmaceutical composition developed on its basis.
The aim of the study is to optimize the complexation of Dihydroquercetin with Zn2+ ions in aqueous solution to develop a technological scheme for producing the complex. Previously the reaction parameters for the development of a laboratory scheme for obtaining a complex were determined. An tenfold increase of the volume of the reaction solution (from 50 to 500 ml) led to a decrease in the yield of the product, and the task was to correct some reaction parameters to increase the yield of the complex.
It was established that the increase of the reaction time from 15 to 240 min and the concentration of DHQ in the reaction solution from 0,05 to 0,1 M, while maintaining the previously optimized reaction parameters - the molar ratio of the initial reagents Zn2+ : DKB = 2 : 1, pH 5,6, are increasing the yield of the complex from 12 to 84%. The correspondence between the structures of the complex and of the compound obtained earlier in small volumes have been confirmed by the data IR, 13C and 1H NMR spectroscopy and elemental analysis.
The conducted research will promote the fuller use of extractive substances of larch wood for the creation of new medicines with antioxidant properties for the treatment of various diseases.
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