QUANTITATIVE DETERMINATION OF XANTHONE SUM IN TERMS OF MANGIFERIN IN AERIAN ORGANS OF SPECIES OF GENUS HEDYSARUM L. BY UV SPECTROPHOTOMETRY

UDC 582.736:547.918:581.19:633.875

  • Dzhavgarat Ruslanovna Imachuyeva Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University; Dagestan State Medical University Email: djakag01@gmail.com
  • Fatima Kazbekovna Serebryanaya Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University; Botanical Institute. V.L. Komarov RAS Email: fatimasereb@yandex.ru
  • Ifrat Nazimovich Zilfikarov All-Russian Research Institute of Medicinal and Aromatic Plants Email: dagfarm@mail.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.2020034553
Keywords: Hedysarum caucasicum, Hedysarum grandiflorum, Hedysarum daghestanicum, summary of xanthones, mangiferine, TLC, UV spectrophotometry, validation

Abstract

Preparing of the antiviral and antibacterial medicinal plants is a promising task of native pharmacy. In this regard, it is interesting to study species of the genus penny, namely Hedysarum caucasicum M.Bieb., Hedysarum grandiflorum Pall., Hedysarum daghestanicum Rupr. ex. Boiss., the regions of distribution, chemical composition and known pharmacological properties will allow to justify directions of their rational use, as well as creation of new phytopreparations of antiviral action on the basis of medicinal raw materials.

During the complex pharmacognostic studies of three species of Hedysarum L. we have developed the method for isolation and quantitative determination of the sum of xanthones in terms of mangiferin by UV spectrophotometry. The technique takes into account the basic physical and chemical properties of xanthones, is characterized by reproducibility, high accuracy, simplicity of implementation, allows to carry out both screening evaluation of various raw objects containing mangiferin derivatives, as well as standardization of the prepared medicinal plant raw material of the penny. The developed methods are tested on the aerian organs of Hedysarum L. species, collected and dried taking into account the rules and requirements of drug raw material procurement. As a result, Hedysarum caucasicum M.Bieb herb (0.624%) was found to be the highest quantitative amount of xanthone sum in terms of mangiferin. The obtained results show the prospect of further research of the aerian part of the Hedysarum caucasicum M.Bieb. as an additional source of mangiferin.

The method of quantitative determination of xanthone sum in the list for mangiferin in the above-ground part of Hedysarum caucasicum M.Bieb; Based on the obtained data, it has been found that the proposed technique is highly sensitive, reproducible and usable.

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Author Biographies

Dzhavgarat Ruslanovna Imachuyeva, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University; Dagestan State Medical University

аспирант

Fatima Kazbekovna Serebryanaya, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University; Botanical Institute. V.L. Komarov RAS

кандидат фармацевтических наук, доцент кафедры фармакогнозии, ботаники и технологии фитопрепаратов, научный сотрудник

Ifrat Nazimovich Zilfikarov, All-Russian Research Institute of Medicinal and Aromatic Plants

доктор фармацевтических наук, профессор, главный научный сотрудник отдела фитохимии и стандартизации

References

Imachuyeva D.R., Serebryanaya F.K. Farmatsiya i farmakologiya, 2016, vol. 4(6), pp. 4–32. (in Russ.).

Fedorova Yu.S., Kul'pin P.V., Suslov N.I., Melent'yeva Yu.V., Kosenko K.K. Vestnik nauki i obrazovaniya, 2018, vol. 16-1(52), pp. 85–91. (in Russ.).

Glyzin V.I., Ban'kovskiy A.I., Pimenov M.G., Boryayev K.I. Khimiya prirodnykh soyedineniy, 1973, no. 3, pp. 434–435. (in Russ.).

Kuvayev V.B., Glyzin V.I., Glyzina G.S., Ban'kovskiy A.I. Rastitel'nyye resursy, 1972, vol. 8 (3), pp. 367–371. (in Russ.).

Krivut B.A., Fedyunina N.A., Kocherga S.I., Rusakova S.V. Khimiya prirodnykh soyedineniy, 1976, no. 1, pp. 44–46. (in Russ.).

Solov'yeva Ye.V., Khotsialova L.I., Krivut B.A., Glyzin V.I., Maysuradze N.I. Rastitel'nyye resursy, 1983, vol. 19(3), pp. 356–360. (in Russ.).

Nechepurenko I.V., Polovinka M.P., Komarova N.I., Salakhutdinov N.F., Nechepurenko S.B. Khimiya prirodnykh soyedineniy, 2008, no. 1, pp. 3–9. DOI: 10.1007/s10600-008-0009-9. (in Russ.).

Liu Y., Zhang Z., Zhang Q.Y., Pu X.P., Zhao Y.Y. China Pharm., 2010, vol. 24, pp. 543–549.

Dong Y., Tang D., Zhang N. et al. Chem. Cent. J., 2013, vol. 7(1), p. 124. DOI: 10.1186/1752-153X-7-124.

Liu Y., Zhao Y.Y., Chen H.B., Wang B., Zhang Q.Y. Nat Prod Commun., 2010, vol. 5 (4), pp. 541–544.

Liu Y., Chen H.B., Zhao Y.Y., Wang B., Zhang Q.Y., Zhang L., Tu P.F. J. Agric. Food Chem., 2006, vol. 54, pp. 6634–6639.

Hai L.Q., Zhang Q.Y., Liang H., Zhao Y.Y., Du N.S. Acta Pharm Sinica., 2003, vol. 38, pp. 592–595.

Huang Z., Cui Z., Ren Y., Zhang J., Cran M. Zhongcaoyao, 1992, vol. 23 (9), pp. 469–473.

Neretina O.V., Gromova A.S., Lutskiy V.I., Semenov A.A. Rastitel'nyye resursy, 2004, vol. 40 (4), pp. 111–138. (in Russ.).

Kukushkina T.A., Zinner N.S., Vysochina G.I., Sviridova T.P. Khimiya rastitel'nogo syr'ya, 2011, no. 3, pp. 113–116. (in Russ.).

Denisova O.A., Glyzin V.I., Patudi A.V., Gavrilenko B.D. Khimiko-farmatsevticheskiy zhurnal, 1980. vol. 14, no. 12, pp. 76–77. (in Russ.).

Neretina O.V., Fedorov S.V., Gromova A.S., Lutskiy V.I., Yel'kin Yu.N. Khimiya prirodnykh soyedineniy, 2002, no. 2, p. 161. (in Russ.).

Kitanov G., Blinova K.F. Khimiya prirodnykh soyedineniy, 1978, no. 4, p. 524. (in Russ.).

Fomina L.I., Satsyperova I.F., Bandyukova V.A. Rastitel'nyye resursy, 1990, vol. 25(3), pp. 431–437. (in Russ.).

Alpizarin. [Electronic resource] URL: http://www.biomedservice.ru/preparat/libr_alpizarin.pdf (in Russ.).

Kukushkina T.A., Vysochina G.I., Karnaukhova N.A., Selyutina I.Yu. Rastitel'nyye resursy, 2011, vol. 47 (1), pp. 99–105. (in Russ.).

Komissarenko A.N., Nadezhina T.P., Komissarenko N.F. Khimiya prirodnykh soyedineniy, 1994, no. 4, pp. 564–565. (in Russ.).

Isakov V.A., Isakov D.V., Arkhipova Ye.I., Arkhipov G.S. Vestnik NovGU, 2019, no. 3 (115), pp. 31–35. (in Russ.).

Gosudarstvennaya farmakopeya Rossiĭskoĭ Federatsii: XIV izd., v 4 t. [State Pharmacopoeia of the Russian Federation: XIV ed., In 4 volumes]. Moscow, 2018, URL: http://femb.ru/femb/pharmacopea.php (in Russ.).

Published
2020-10-22
How to Cite
1. Imachuyeva D. R., Serebryanaya F. K., Zilfikarov I. N. QUANTITATIVE DETERMINATION OF XANTHONE SUM IN TERMS OF MANGIFERIN IN AERIAN ORGANS OF SPECIES OF GENUS HEDYSARUM L. BY UV SPECTROPHOTOMETRY // chemistry of plant raw material, 2020. № 3. P. 179-186. URL: http://journal.asu.ru/cw/article/view/4553.
Issue
No 3 (2020)
Section
Low-molecular weight compounds

Copyright (c) 2020 chemistry of plant raw material

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