BIOLOGICALLY ACTIVE SUBSTANCES EXHIBITING ANTIOXIDANT ACTIVITY, SOME REPRESENTATIVES OF THE LAMIACEAE FAMILY CULTIVATED IN THE STAVROPOL REGION
UDC 615.322:581.192:582.929.4
Abstract
The object of the study was the samples of raw materials of the family Lamiaceae plants created in FSBSI "North Caucasus Federal agricultural research center", using a variety of breeding methods: Salvia Officinalis Leaves (cultivar "Dobrynya"), Origanum Vulgare Herb (cultivar "Karamelka"), Salvia Sclarea Herb (cultivar "Salyut"), Satureja Hortensis Herb (cultivar "Karapuz"), Lophanthus Anisatus Herb (cultivar "Premier"), Hyssopus Officinalis Herb (cultivar "Rozovy flamingo"). As a result of the studies conducted by the method of high-performance liquid chromatography, the component composition of phenolic compounds (flavonoids and phenolcarbonic acids) was established. The quantitative content of essential oil, flavonoids and tannins was determined in the studied objects. In salvia officinalis leaves identified 11 phenolic compounds, 2.72% essential oil, 1.22% flavonoids, 12.20% tannins; in origanum vulgare herb – 9 compounds, 1.80% essential oil, 2.10% flavonoids, 8.64% tannins; in salvia sclarea herb – 11 compounds, 0.45% essential oil, 2.25% flavonoids, 10.51% tannins; in satureja hortensis herb – 11 compounds, 0.68% essential oil, 0.85% flavonoids, 9.37% tannins; in lophanthus anisatus herb – 11 compounds, 2.15% essential oil, 2.06% flavonoids, 8.30% tannins; in hyssopus officinalis herb – 9 compounds, 0.78% essential oil, 0.91% flavonoids, 9.55% tannins. Determination of antioxidant activity, conducted in two ways (amperometric and titrimetric) showed that water-alcohol extraction of plant raw materials of new varieties of representatives of the family Lamiaceae, created and maximally adapted to the conditions of Stavropol region can be the basis for the production of herbal remedies with antioxidant activity.
Downloads
Metrics
References
Yankovskiy O.Yu., Kuznetsov S.I. Vestnik SPbGU. Biologiya, 2005, no. 4, pp. 40–52. (in Russ.).
Il'ina I.G., Rudakova I.P., Samylina I.A. Farmatsiya, 2013, no. 8, pp. 3–7.(in Russ.).
Islamova F.I., Musayev A.M., Radzhabov G.K., Vagabova F.A., Guseynova Z.A., Mamaliyeva M.M. Voprosy biolo-gicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2016, vol. 19 (12), pp. 19–22. (in Russ.).
Kotas M.E., Medzhitov R. Cell., 2015, vol. 160 (5), pp. 816–827. DOI: 10.1016/j.cell.2015.02.010.
Smit A. Farmatsiya, 2016, no. 8, pp. 53–56. (in Russ.).
Duletic-Lausevic S., Alimpic A., Pavlovic D., Marin P.D., Lakusic D. Agro FOOD Industry Hi Tech, 2016, vol. 27(1), pp. 52–55.
Mughal U.R., Mehmood R., Malik A., Alia B., Tareen R.B. Helvetica Chimica Acta, 2012, vol. 95 (1), pp. 100–105. DOI: 10.1002/hlca.201100214.
Lubsandorzhiyeva P.B., Azhunova T.A. Farmatsiya, 2015, no. 6, pp. 43–46. (in Russ.).
Pavlova S.I., Albegova D.Z., Vorob'yeva Yu.S., Laptev O.S., Kozlov I.G. Khimiko-farmatsevticheskiy zhurnal, 2015, vol. 49, no. 10, pp. 3–10. DOI: 10.30906/0023-1134-2015-49-10-3-10. (in Russ.).
Krylova N.V., Popov A.M., Leonova G.N. Antibiotiki i khimioterapiya, 2016, vol. 61, no. 5–6, pp. 25–31.(in Russ.).
Firuzi O., Miri R., Tavakkoli M., Saso L. Curr. Med. Chem., 2011, vol. 18 (25), pp. 3871–3888. DOI: 10.2174/092986711803414368.
Toropova A.A., Badmayev N.S., Razuvayeva Ya.G., Nikolayev S.M., Sambuyeva Z.G., Yerentuyeva A.Yu. Ekspe-rimental'naya i klinicheskaya farmakologiya, 2017, vol. 80, no. 7, pp. 11–14. DOI: 10.30906/0869-2092-2017-80-7-11-14 (in Russ.).
Navolokin N.A., Ivlichev A.V., Mudrak D.A., Afanas'yeva G.A., Polukonova N.B., Tychina S.A., Bucharskaya A.B., Maslyakova G.N. Eksperimental'naya i klinicheskaya farmakologiya, 2017, vol. 80, no. 10, pp. 40–43. DOI: 10.30906/0869-2092-2017-80-10-40-43 (in Russ.).
Borovskaya T.G., Kamalova S.I., Krivova N.A., Zayeva O.B., Poluektova M.Ye., Vychuzhanina A.V., Grigor'ye-va V.A., Plotnikov M.B., Gol'dberg V.Ye. Byulleten' eksperimental'noy biologii i meditsiny, 2018, vol. 166, no. 7, pp. 10–13. (in Russ.).
Bushuyeva G.R., Lupanova I.A. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2017, vol. 20, no. 11, pp. 8–12. (in Russ.).
Chillar R., Dhigra D. Fundamental and Clinical pharmacology, 2013, vol. 27 (4), pp. 409–418. DOI: 10.1111/j.1472-8206.2012.01040.x.
Kontogianni V.G., Tomic G., Nikolic I., Nerantzaki A.A., Sayyad N., Stosic-Grujicic S., Stojanovic I. Food Chemistry, 2013, vol. 136 (1), pp. 120–129. DOI: 10.1016/j.foodchem.2012.07.091.
Verma S., Singh A., Mishra A.A. Environmental Toxicology and Pharmacology, 2013, vol. 35 (3), pp. 473–485. DOI: 10.1016/j.etap.2013.02.011.
Rudakova YU.G., Popova O.I. Meditsinskiy vestnik Severnogo Kavkaza, 2016, vol. 11 (3), pp. 425–428. DOI: 10.14300/mnnc.2016.11094. (in Russ.).
Tokhsyrova Z.M., Popov I.V., Popova O.I. Khimiya rastitel'nogo syr'ya, 2018, no. 3, pp. 199–207. DOI: 10.14258/jcprm.2018033733. (in Russ.).
Tokhsyrova Z.M., Popova O.I. Farmatsiya, 2009, no. 1, pp. 24–25. (in Russ.).
Chumakova V.V., Mezenova T.D., Popova O.I. Meditsinskiy vestnik Severnogo Kavkaza, 2010, no. 4, pp. 75–76. (in Russ.).
Gavrilin M.V., Popova O.I., Gubanova Ye.A. Khimiya rastitel'nogo syr'ya, 2010, no. 4, pp. 99–104. (in Russ.).
Popova O.I., Chumakova V.V., Nikitina A.S., Tanskaya Yu.V., Gubanova Ye.A. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2010, no. 9, pp. 11–18. (in Russ.).
Gubanova Ye.A., Popova O.I. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2010, no. 3, pp. 42–44. (in Russ.).
Chumakova V.V., Popova O.I. Farmatsiya, 2011,no. 3,pp. 20–22. (in Russ.).
Trineyeva O.V., Slivkin A.I. Farmatsiya, 2014,no. 1, pp. 16–19. (in Russ.).
Gosudarstvennaya farmakopeya RF. XIII izd.[The State Pharmacopoeia of the Russian Federation. XIII ed.]. Moscow, 2015, URL: http://pharmacopoeia.ru/gosudarstvennaya-farmakopeya-xiii-online-gf-13-online. (inRuss.).
Leonova V.N., Popova O.I., Krasovskaya A.V. Khimiya rastitel'nogo syr'ya, 2016, no. 4, pp. 117–122. DOI: 10.14258/jcprm.2016041341 (inRuss.).
Rudakova Yu.G., Senchenko S.P., Popova O.I. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2014, vol. 12 (3), pp. 34–37. (inRuss.).
Chumakova V.V., Popova O.I., Kodonidi M.I. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2012, no. 12, pp. 30–33.(inRuss.).
Shilova I.V., Korotkova Ye.I. Khimiko-farmatsevticheskiy zhurnal, 2017, vol. 51 (7), pp. 46–49.(in Russ.).
Yendonova G.B., Antsupova T.P., Bazhenova B.A., Zabaluyeva Yu.Yu., Gerasimov A.V. Khimiya rastitel'nogo syr'ya, 2018, no. 4, pp. 141–147. DOI: 10.14258/jcprm.2018043749.(in Russ.).
Bubenchikov R.A., Pozdnyakova T.A. Voprosy obespecheniya kachestva lekarstvennykh sredstv, 2014, no. 5, pp. 31–33. (in Russ.).
Copyright (c) 2019 Khimiya Rastitel'nogo Syr'ya (Chemistry of plant raw material)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.