PHENYLPROPANOIDS OF PARASENECIO HASTATUS (COMPOSITAE) AND THEIR WOUND-HEALING ACTIVI-TY
UDC 582.998+615.322:577.13
Abstract
Parasenecio hastatus (L.) H. Koyama (Cacalia hastata L., Compositae) is a well-known medicinal plant widespread in Siberia and Southeast Asia and used in the practice of traditional medicine in Asian countries as a wound-healing remedy. Scientific research confirmed the effectiveness of drugs containing P. hastatus, however, there is no any information about active substances identified (Ayushieva et al., 2007, 2009). In this work, it was revealed that the butanol fraction of P. hastatus leaves showed the most pronounced wound-healing effect. As a result of chromatographic separation of this fraction, 12 phenylpropanoids were identified as 5-O-caffeoylquinic acid, caffeic acid, and for the first time 4-O-caffeoylquinic, 1,5-di-O-caffeoylquinic, 3,4-di-O-caffeoylquinic, 3,5-di-O-caffeoylquinic, 4,5-di-O-caffeoylquinic, 3,4,5-tri-O-caffeoylquinic, chichoric, 3-O-feruloylquinic, 5-O-feruloylquinic acids and echinacoside. Using the microcolumn HPLC, it was established that the maximum content of phenylpropanoids in P. hastatus leaves is observed in the mass flowering period (60.83 mg/g). Compounds 5-O-caffeoylquinic acid (16.34–39.37 mg/g) and 3,5-di-O-caffeoylquinic acid (10.77–22.87 mg/g) were the dominant components of the phenolic complex as well as the main active substances with wound-healing effect. It was shown that the activity of 3,5-di-O-caffeoylquinic acid was higher than the activity of 5-O-caffeoylquinic acid. Thus, it was demonstrated that caffeoylquinic acids and the drugs containing them are promising wound-healing agents.
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