FEATURES OF THE COMPOSITION MACRO ELEMENTS AND TRACE ELEMENTS OF THE EXTRACT OF ALFREDIA CERNUA (L.) CASS., POSSESSING PSYCHOTROPIC EFFECT
UDC 581.192(571.1)
Abstract
The 95% ethanol extract of Alfredia drooping Alfredia cernua (L.) Cass. (Asteraceae) aerial part exhibits pronounced antidepressant, nootropic and anxiolytic activity. The aim of the work was the qualitative and quantitative analysis of macro-, trace and ultra trace elements of the pharmacologically active extract of the aerial part of the plant. The study of the elemental composition of the extract was performed after ashing using instrumental neutron activation analysis with irradiation with thermal neutrons. The study found 26 elements, of which eight are (conditionally) essential, two macro elements and four trace elements. The obtained results indicate the prevalence of Alfredia cernua of calcium, zinc, sodium, strontium, bromine, as well as iron, barium, cobalt, chromium and lanthanum in the pharmacologically active extract. The extract concentrates a specific group of elements (zinc, cobalt, thorium, hafnium, bromine, chromium, lutetium, lanthanum, strontium, samarium) in comparison with the feedstock, which can be explained by the formation of strong organometallic compounds and chelate complexes. Macro-, trace and ultra trace elements can have a significant impact on metabolic processes, nervous, immune, endocrine, cardiovascular systems, they are an integral part of enzymes, give other biologically active substances an easily digestible form and potentiate their effects.
Downloads
Metrics
References
Shilova I.V., Suslov N.I., Samylina I.A. Khimicheskiy sostav i nootropnaya aktivnost' rasteniy Sibiri. [Chemical composition and nootropic activity of Siberian plants]. Tomsk, 2010, 236 p. (in Russ.).
Amel'chenko V.P., Shilova I.V., Kuvacheva N.V. Rastitel'nyye resursy, 2009, vol. 45, no. 2, pp. 23–31. (in Russ.).
Patent 2292214 (RU). 27.01.2007. (in Russ.).
Patent 2347580 (RU). 27.02.2009. (in Russ.).
Mustafin R.N., Shilova I.V., Suslov N.I. Rastitel'nyye resursy, 2011, vol. 47, no. 3, pp. 130–136. (in Russ.).
Patent 2560517 (RU). 20.08.2015. (in Russ.).
Shilova I.V., Samylina I.A., Suslov N.I. Razrabotka nootropnykh sredstv na osnove rasteniy Sibiri. [Development of nootropic drugs based on Siberian plants]. Tomsk, 2013, 268 p. (in Russ.).
Shilova I.V. Vestnik RUDN. Seriya Meditsina, 2007, no. 6, pp. 236–240. (in Russ.).
Shilova I.V. Khimicheskiy sostav rasteniy Sibiri i razrabotka nootropnykh sredstv na ikh osnove: avtoref. dis. … dokt. farm. nauk. [The chemical composition of Siberian plants and the development of nootropic drugs based on them: ab-stract. dis. ... doctor farm. sciences]. Pyatigorsk, 2011, 48 p. (in Russ.).
Shilova I.V., Semenov A.A., Kuvacheva N.V., Suslov N.I., Mustafin R.N. Pharmaceutical Chemistry Journal, 2012, vol. 46, no. 6, pp. 363–368.
Shilova I.V., Kukina T.P., Suslov N.I., Salnikova O.I., Mustafin R.N. Pharmaceutical Chemistry Journal, 2014, vol. 48, no. 3, pp. 181–185.
Shilova I.V., Krasnov E.A., Baranovskaya N.V., Pyak A.I., Nekratov N.F. Pharmaceutical Chemistry Journal, 2002, vol. 36, no. 11, pp. 613–616.
Shilova I.V., Krasnov Ye.A., Baranovskaya N.V., Pyak A.I., Nekratov N.F. Rastitel'nyye resursy, 2002, vol. 38, no. 4, pp. 69–74. (in Russ.).
Shilova I.V., Baranovskaya N.V., Suslov N.I. Rastitel'nyye resursy, 2012, vol. 48, no. 3, pp. 414–420. (in Russ.).
Avtsyn A.P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Mikroelementozy cheloveka: etiologiya, klassifikatsiya, organopatologiya. [Human microelementoses: etiology, classification, organopathology]. Moscow, 1991, 478 p. (in Russ.).
Anke M. Mengen- und Spurenelemente, Jena, 1998, 1055 p.
Kuvacheva N.V., Shilova I.V. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii, 2011, no. 5, pp. 9–12. (in Russ.).
Shilova I.V. Geokhimiya zhivogo veshchestva: materialy Mezhdunarodnoy molodezhnoy shkoly-seminara, posvyashchennoy 150-letiyu so dnya rozhdeniya V.I. Vernadskogo (1863–2013). [Geochemistry of living matter: ma-terials of the International Youth School-Seminar dedicated to the 150th birthday of V.I. Vernadsky (1863–2013)]. Tomsk, 2013, pp. 111–115. (in Russ.).
Kudrin A.V., Gromova O.A. Mikroelementy v nevrologii. [Trace elements in neurology]. Moscow, 2006, 304 p. (in Russ.).
Raytses V.S. Neyrofiziologicheskiye osnovy deystviya mikroelementov. [Neurophysiological basis of the action of trace elements]. Leningrad, 1981, 152 p. (in Russ.).
Jomova K., Vondrakova D., Lawson M., Valko M. Molecular and Cellular Biochemistry, 2010, vol. 345, no. 1–2, pp. 91–104.
Suslov N.I., Shilova I.V., Afanas'yeva O.G. Traditsionnaya meditsina, 2011, no. 5, pp. 388–393. (in Russ.).
Afanasieva O.G., Suslov N.I., Shilova I.V. Bulletin of Experimental Biology and Medicine, 2012, vol. 154, no. 2, pp. 224–227.
Krebs N., Langkammer C., Goessler W., Ropelec S., Fazekas F., Yene K., Scheurer E. Journal of Trace Elements in Medicine and Biology, 2014, vol. 28, no. 1, pp. 1–7. DOI: 10.1016/j.jtemb.2013.09.006
Otmakhov V.I., Kataeva N.G., Kuskova I.S., Petrova E.V., Shilova I.V. Key Engineering Materials: Multifunctional Chemical Materials and Technologies, 2016, vol. 670, pp. 207–212. DOI:10.4028/www.scientific.net/KEM.670.207
Gulyayev S.M. Tserebroprotektornoye deystviye lantana atsetata pri eksperimental'noy ishemii golovnogo mozga : avtoref. dis. … kand. biol. nauk. [The cerebroprotective effect of lanthanum acetate in experimental cerebral ischemia: abstract. dis. ... cand. biol. sciences]. Ulan-Ude, 2004, 21 p. (in Russ.).
![](http://journal.asu.ru/public/journals/1/article_5422_cover_ru_RU.jpg)
Copyright (c) 2019 Khimiya Rastitel'nogo Syr'ya (Chemistry of plant raw material)
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.