DRYING OF THE NEW WATER-SOLUBLE POLYMER COMPLEX OF ALBENDAZOL WITH PECTIN
UDC 547.587.11
Abstract
The drying process of the aqueous solution of the complex of Albendazole with pectin (Alpec) in a vacuum oven and by spray drying was studied. It was found that the drying in a nozzle-type spray dryer is preferable in yield and subsequent solubility of the final product. As a result of the studying of the parameters affecting to the drying process, the optimal mode of the dryer was established, which provides the high yield of the dry product: the temperature of the coolant at the inlet is 130–140 °С, the output is 60–70 °С, the solution flow rate is 2.5 l/h·min. The yield of the dry product is 85%.
The comparative IR spectra of Alpec powder after spray drying, after drying in air, the starting Albendazole and pectin unambiguously indicate that the structure of the complex of Albendazole with pectin (Alpec) is identical after different types of drying.
The biological activity of Alpec dry substance after spray drying compared with Albendazole was studied. The increased biological activity of Alpec compared with Albendazole was established, which can, probably, be explained by the good water solubility of Alpec in contrast to Albendazole and, as a consequence, the increase of bioavailability of the drug. It was found that the average lethal dose of Alpec (LD50) is 680 (601.8–768.4) mg·kg-1 (LD50 Albendazole - 400.2–450.4 mg·kg-1), i.e. the drug "Alpec" in terms of acute toxicity during intragastric use is classified as moderately hazardous substances.
On the base of the results obtained, the technology of the obtaining of the anthelmintic drug alpec substance in the form of a water-soluble dry powder has been developed.
Downloads
Metrics
References
Ganguly M. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 2017, vol. 3, no. 4, pp. 16–25.
Sriamornsak P. Int. J. Pharm., 2002, vol. 44, pp. 207–228.
Modi K., Modi M., Mishra D., Panchal M., Sorathiya U., Shelat P. Int. Res. J. Pharm., 2013, vol. 4(3), pp. 70–76.
Sarma B.R., Naresh L., Dhuldhoya N.C., Merchant S.U., Merchant U.C. Times Food Process. J., 2006, pp. 44–51.
Mishra R.K., Banthia A.K., Majeed A.B.A. Asian J. Pharm. Clin. Res., 2012, vol. 5(4), pp. 1–7.
Aggarwal S., Pahuja S. Int. Res. J. Pharm., 2013, vol. 4(2), pp. 45–51.
Farris S., Schaich K.M., Liu L.S., Cooke P.H., Piergiovanni L., Yam K.L. Food Hydrocoll., 2011, vol. 25, pp. 61–70.
Kostin V.I., Mikheyeva L.A., Ofitserov Ye.N. Vestnik ul'yanovskoy gosudarstvennoy sel'skokhozyaystvennoy akademii, 2013, no. 1 (21), pp. 49–54. (in Russ.).
Khayrullina R.R., Timerbayeva G.R., Shurshina A.S. Vestnik Bashkirskogo universiteta, 2017, vol. 22, no. 1, pp. 69–71. (in Russ.).
Grigor'yeva M.V. Biotechnologia Acta, 2011, vol. 4, no. 2, pp. 9–23. (in Russ.).
Lapin A.A., Sosnina N.A., Morozov V.I. i dr. Khimiya i komp'yuternoye modelirovaniye. Butlerovskiye soobshcheniya, 2001–2002, vol. 2, no. 5–8, pp. 21–24. (in Russ.).
Beriketov A.S., Atova R.A., Oytov Kh.Z. Izv. Vuzov. Severo-Kavkazskiy region. Yestestv. nauki, 2004, no. 2, pp. 63–64. (in Russ.).
Lyuboshits I.L., Slobodkin L.S., Pikus I.F. Sushka dispersnykh termochuvstvitel'nykh materialov. [Drying of dispersed heat-sensitive materials]. Minsk, 1969, 97 p. (in Russ.).
Golubev L.G., Sazhin B.S., Valashek Ye.R. Sushka v khimiko-farmatsevticheskoy promyshlennosti. [Drying in the chemical and pharmaceutical industry]. Moscow, 1978, 272 p. (in Russ.).
Abdurakhmanov B.A., Turayeva S.M., Ibragimov T.F., Khalilov R.M. Khimiya rastitel'nogo syr'ya, 2019, no. 1, pp. 170–177. (in Russ.).
OST 91500.05.001-00. Standarty kachestva lekarstvennykh sredstv. Osnovnyye polozheniya. [OST 91500.05.001-00. Medicines quality standards. Basic provisions]. Moscow, 2000. (in Russ.).
Sushil'nyye apparaty i ustanovki. Katalog. Izd. 4-ye ispravlennoye i dopolneniye. [Dryers and installations. Catalog. Ed. 4th corrected and addition]. Moscow, 1983, 56 p. (in Russ.).
Zukhurova G.V., Sadikov T., Makhmudova B.Sh., Eshimbetov A.G., Abdurazakov A.Sh., Sagdullaev Sh.Sh. 11th In-ternational Symposium on the Chemistry of Natural Compounds 1-4 October. Antalya, 2015, p. 157.
Mirzaeva M.R., Rakhmanberdyeva R.K., Kristallovich Е.L., Rakhimov D.A., Shtonda N.I. Chemistry of Natural Com-pounds, 1998, vol. 34, pp. 653–655.
Klug H., Alexander L. X-ray diffraction Procedures (2nd ed.). Canada: John Wiley & Sons, Inc., 1954, 122 p.
Abdurazakov A., Khvan А., Zukhurova G., Islamova J., Mirzakhidov Kh. Austrian Journal of Technical and Natural Sciences, 2020, no. 3–4, pp. 23–31.
Zukhurova G.V., Sadikov T., Saidov S.S., Karimov R.K., Abdurazakov A.Sh. Farmatsevticheskiy zhurnal, 2018, no. 3, pp. 64–69. (in Russ.).
Petrovichev O.A., Aleksanyan I.Yu. Vestnik AGTU, 2006, no. 6 (35), pp. 154–158. (in Russ.).
Guba O.Ye., Abuova G.B., Derbasova Ye.M. Vestnik ChGU, Tekhnicheskiye nauki, 2016, no. 4, pp. 7–12. (in Russ.).
GOST 8.207-76. Pryamyye izmereniya s mnogokratnymi nablyudeniyami. Metody obrabotki rezul'tatov nablyu-deniy. Osnovnyye polozheniya. [GOST 8.207-76. Direct measurements with multiple observations. Methods for processing the results of observations. Basic provisions]. Moscow, 2006, 8 p. (in Russ.).
Lykova N.I. Mediko-biologicheskoye obosnovaniye ispol'zovaniya modeley Aspiculuris tetraptera i Syphacia obvelata dlya poiska i sozdaniya novykh preparatov: aftoref. dis. … kand. biol. nauk. [Biomedical substantiation of the use of Aspiculuris tetraptera and Syphacia obvelata models for the search and creation of new drugs: aftoref. dis. ... Cand. biol. sciences]. Moscow, 1994, 23 p. (in Russ.).
Khabriyev R.U. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh vesh-chestv. [Guidelines for experimental (preclinical) study of new pharmacological substances]. Moscow, 2005, 593 p. (in Russ.).
Irikov O.A., Kovalenko F.P. Med. parazitol. i parazitarnyye bolezni, 2007, no. 3, pp. 7–11. (in Russ.).
Copyright (c) 2021 chemistry of plant raw material
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.
