STEVIA (STEVIA REBAUDIANA BERTONI): BIOCHEMICAL COMPOSITION, THERAPEUTIC PROPERTIES AND USE IN THE FOOD INDUSTRY (REVIEW)

UDC 633.66:615.322: 664.162.81

  • Aleksey Aleksandrovich Kochetov Agrophysical Research Institute Email: kochetoval@yandex.ru
  • Nadezhda Georgiyevna Sinyavina Agrophysical Research Institute Email: sinad@inbox.ru
Keywords: stevia (Stevia rebaudiana Bertoni), diterpene glycosides, biochemical composition, therapeutic properties, use in the food industry

Abstract

The review presents the current state of the science for stevia (Stevia rebaudiana Bertony), its biochemical composition, therapeutic properties and using in the food industry. Interest in this plant, a source of natural low-calorie sweeteners, is associated with increased consumption of dietary sweeteners, caused by an increase in the number of patients with diabetes, metabolic syndrome, and with many negative effects from the use of synthetic sweeteners. Diterpene glycosides from stevia have a high sweetness (50-350 times sweeter than sucrose), low calorie content, safe for human health. In addition to them, a number of biologically valuable compounds (mineral elements, vitamins, proteins, amino acids, oligosugars, fiber, polyphenols) were found in the leaves of stevia. High antioxidant properties of stevia leaf extracts has been shown, which allows them to be used in the food industry in the production of functional products. Numerous data have been obtained on the various therapeutic properties of stevia. It has been revealed that regular use of stevia glycosides reduces blood glucose and cholesterol levels, promotes cell regeneration, inhibits the growth of tumor cells and strengthens blood vessels. Components from stevia leaves have a choleretic, diuretic effect, normalize blood pressure, prevent diseases of the gastrointestinal tract, and have a beneficial effect on kidney function. Stevia extracts also have antibacterial, antiviral, anti-inflammatory and immunomodulatory effects. The safety and stability of stevia sweet glycosides in an acidic environment and at high temperatures allows them to be widely used in the production of products such as diet drinks, teas, sauces, marinades, seafood, ice cream, yogurts, pastries, culinary products and sweets.

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Author Biographies

Aleksey Aleksandrovich Kochetov, Agrophysical Research Institute

ведущий научный сотрудник, кандидат биологических наук

Nadezhda Georgiyevna Sinyavina , Agrophysical Research Institute

старший научный сотрудник, кандидат биологических наук

References

Global'nyy doklad po diabetu. [Global report on diabetes]. Zheneva: WHO, 2016, 88 p. (in Russ.).

Brandle J.E., Starratt A.N., Gijzen M. Canadian Journal of plant science, 1998, vol. 78(4), pp. 527–536.

Kennelly E.J. Stevia: The Genus Stevia, CRC Press, 2001, pp. 81–99.

Kinghorn A.D., Soejarto D.D., Kennelly E.J., Kim D.S., Ohtani K., Yamasaki K., Choi Y.H. Med. Arom. Plants-Ind. Profiles, 2002, vol. 19, pp. 52–64.

Goyal S.K., Samsher G.R.K., Goyal R.K. Int. J. Food Sci. Nutr., 2010, vol. 61(1), pp. 1–10. DOI: 10.3109/09637480903193049.

Yadav A.K., Singh S., Dhyani D., Ahuja P.S. Canadian Journal of Plant Science, 2011, vol. 91(1), pp. 1–27. DOI: 10.4141/CJPS10086.

Lemus-Mondaca R., Vega-Galvez A., Zura-Bravo L., Ah-Hen K. Food Chem., 2012, vol. 132, pp. 1121–1132. DOI: 10.1016/j.foodchem.2011.11.140.

Wölwer-Rieck U. Journal of agricultural and food chemistry, 2012, vol. 60(4), pp. 886–895. DOI: 10.1021/jf2044907.

Gupta E., Purwar S., Sundaram S., Rai G.K. Journal of Medicinal Plants Research, 2013, vol. 7(46), pp. 3343–3353. DOI: 10.5897/JMPR2013.5276.

Gasmalla M.A.A., Yang R., Hua X. Food Engineering Reviews, 2014, vol. 6(4), pp. 150–162. DOI: 10.1007/s12393-014-9080-0.

Kobus-Moryson M., Gramza-Michałowska A. Acta Scientiarum Polonorum Technologia Alimentaria, 2015, vol. 14(1), pp. 5–13. DOI: 10.17306/J.AFS.2015.1.1.

Marcinek K., Krejpcio Z. Journal für Verbraucherschutz und Lebensmittelsicherheit, 2016, vol. 11(1), pp. 3–8. DOI: 10.1007/s00003-015-0968-2.

Sivaram L., Mukundan U. In Vitro Cellular & Developmental Biology-Plant, 2003, vol. 39(5), pp. 520–523. DOI: 10.1079/IVP2003438.

Stoyanova S., Geuns J., Hideg E., Van Den Ende W. International Journal of Food Sciences and Nutrition, 2011, vol. 62(3), pp. 207–214. DOI: 10.3109/09637486.2010.523416.

Munz S., Präger A., Merkt N., Claupein W., Graeff-Hönninger S. Industrial Crops & Products, 2018, vol. 111, pp. 520–528. DOI: 10.1016/j.indcrop.2017.11.021.

Kolesnikova Ye.O., Galdina T.Ye. Natsional'naya Assotsiatsiya Uchenykh, 2015, no. 3–6 (8), pp. 106–108. (in Russ.).

Kononova Ye.A. Ekologo-biologicheskiye osobennosti novykh sortov stevii Stevia rebaudiana (Bertoni) Hemsley pri vvedenii v kul'turu v Tsentral'nom Predkavkaz'ye: avtoref. dis. …kand. s/kh nauk. [Ecological and biological features of new stevia varieties Stevia rebaudiana (Bertoni) Hemsley when introduced into cultivation in the Central Ciscaucasia: author. dis. ... Cand. agricultural sciences]. Krasnodar, 2015, 24 p. (in Russ.).

Kuznetsova I.V. Vestnik Belorusskoy gosudarstvennoy sel'skokhozyaystvennoy akademii, 2014, no. 1, pp. 106–110. (in Russ.).

Stevia Market. 2017. URL: https://www.marketsandmarkets.com/Market-Reports/stevia-market-167065378.html.

Mirovyye tseny na produkty iz stevii [World prices for stevia products]. URL: https://www.made-in-chi-na.com/productdirectory.do?word=stevia&file=&subaction=hunt&style=b&mode=and&code=0&comProvince=nolimit&order=0&isOpenCorrection=1. (in Russ.).

Chatsudthipong V., Muanprasat C. Pharmacology & therapeutics, 2009, vol. 121(1), pp. 41–54. DOI: 10.1016/j.pharmthera.2008.09.007.

Tadhani M., Subhash R. J. Medical Sci., 2006, vol. 6, pp. 321–326.

Marković I.S., Đarmati Z.A., Abramović B.F. Journal of the Serbian Chemical Society, 2008, vol. 73(3), pp. 283–297. DOI: 10.2298/JSC0803283M.

Samuel P., Ayoob K.T., Magnuson B.A., Wölwer-Rieck U., Jeppesen P.B., Rogers P.J., Mathews R. The Journal of nutrition, 2018, vol. 148(7), pp. 1186–1205. DOI: 10.1093/jn/nxy102.

Kinghorn A.D., Soejarto N.P.D., Nanayakkara C.M. J. Nat. Prod., 1984, vol. 47(3), pp. 439–444. DOI: 10.1021/np50033a007.

Geuns J.M.C. Phytochemistry, 2003, vol. 64(5), pp. 913–921. DOI: 10.1016/S0031-9422(03)00426-6.

Prakash Ch.V.S., Upreti M., Prakash I. Molecules, 2011, vol. 16(5), pp. 3552–3562. DOI: 10.3390/molecules16053552.

Ceunen S., Geuns J.M.C. Journal of natural products, 2013, vol. 76(6), pp. 1201–1228. DOI: 10.1021/np400203b.

Purkayastha S., Markosyan A., Prakash I., Bhusari S., Pugh Jr G., Lynch B., Roberts A. Regulatory Toxicology and Pharmacology, 2016, vol. 77, pp. 125–133. DOI: 10.1016/j.yrtph.2016.02.015.

Brandle J.E., Telmer P.G. Phytochemistry, 2007, vol. 68(14), pp. 1855–1863. DOI: 10.1016/j.phytochem.2007.02.010.

Puri M., Sharma D., Tiwari A.K. Biotechnology Advances, 2011, vol. 29(6), pp. 781–791. DOI: 10.1016/j.biotechadv. 2011.06.006.

Sitnichuk I.Yu., Strizheva Ye.N., Yefremov A.A., Pervyshina G.G. Khimiya rastitel'nogo syr'ya, 2002, no. 3, pp. 73–75. (in Russ.).

Milani P.G., Formigoni M., Dacome A.S., Benossi L., Costa C.E.D., Costa S.C. Anais da Academia Brasileira de Ciências, 2017, vol. 89(3), pp. 1841–1850. DOI: 10.1590/0001-3765201720170174.

Mishra P., Singh R., Kumar U., Prakash V. Global. J. Biotech. Biochem., 2010, vol. 5, pp. 62–74.

Serio L. Phytothérapie, 2010, vol. 8, pp. 26–32. DOI: 10.1007/s10298-010-0526-4.

Savita S.M., Sheela K., Sunanda S., Shankar A.G., Ramakrishna P. Journal of Human Ecology, 2004, vol. 15(4), pp. 261–264. DOI: 10.1080/09709274.2004.11905703.

Abou-Arab A.E., Abou-Arab A.A., Abu-Salem M.F. African Journal of Food Science, 2010, vol. 4(5), pp. 269–281.

Kaushik R., Pradeep N., Vamshi V., Geetha M., Usha A. J. Food Sci. Technol., 2010, vol. 47(1), pp. 27–33.

Shuvo M.M.A., Mohammad A.M., Chowdhury T., Absar N., Hasanuzzaman M. International Journal of Applied Sci-ences and Biotechnology, 2015, vol. 3(4), pp. 721–726. DOI: 10.3126/ijasbt.v3i4.13972.

El-Nassag D.E., Ghamry H.I., Elhassaneen Y.A. Journal of Studies and Searches of Specific Education, 2019, vol. 5(1), pp. 157–180.

Gasmalla M.A.A., Yang R., Amadou I., Hua X. Tropical Journal of Pharmaceutical Research, 2014, vol. 13(1), pp. 61–65. DOI: 10.4314/tjpr.v13i1.9.

Lemus-Mondaca R., Ah-Hen K., Vega-Galvez A., Honores C., Moraga N.O. Plant Foods for Human Nutrition, 2016, vol. 71 (1), pp. 49–56. DOI: 10.1007/s11130-015-0524-3.

Snehal P., Madhukar K. Asian J. Pharm. Clin. Res., 2012, vol. 5(1), pp. 115–117.

Grozeva N., Pavlov D., Petkova N., Ivanov I., Denev P., Pavlov A., Gerdzhikova M., Dimanova-Rudolf M. Interna-tional Journal of Pharmacognosy and Phytochemical Research, 2015, vol. 7(6), pp. 1236–1243.

De Oliveira A.J.B., Gonçalves R.A.C., Chierrito T.P.C., dos Santos M.M., de Souza L.M., Gorin P.A.J., Iacomini M. Food Chemistry, 2011, vol. 129(2), pp. 305–311. DOI: 10.1016/j.foodchem.2011.04.057.

Rafiq M., Dahot M.U., Mangrio S.M., Naqvi H.A., Qarshi I.A. Pak. J. Bot., 2007, vol. 39(7), pp. 2467–2474.

Periche A., Koutsidis G., Escriche I. Plant foods for human nutrition, 2014, vol. 69(1), pp. 1–7. DOI: 10.1007/s11130-013-0398-1.

Li G., Wang R., Quampah A.J., Rong Z., Shi C., Wu J. Journal of agricultural and food chemistry, 2011, vol. 59(24), pp. 13065–13071. DOI: 10.1021/jf2035912.

Makiyev O.N. Soderzhaniye biologicheski aktivnykh veshchestv v batate kul'turnom (Ipomoea batatas (L.) Lam.), stevii (Stevia rebaudiana Bertoni), solodke shchetinistoy (Glycyrrhiza echinata L.) v usloviyakh RSO-Alaniya i ikh praktich-eskoye ispol'zovaniye: avtoref. diss. … kand. biol. nauk. [The content of biologically active substances in the cultivated sweet potato (Ipomoea batatas (L.) Lam.), Stevia (Stevia rebaudiana Bertoni), bristly licorice (Glycyrrhiza echinata L.) under the conditions of North Ossetia-Alania and their practical use: author. diss. ... Cand. biol. sciences]. Vladikavkaz, 2012, 24 p. (in Russ.).

Trukhachev V.I., Starodubtseva G.P., Bezgina YU.A., Lyubaya S.I., Veselova M.V. Vestnik APK Stavropol'ya, 2012, no. 1, pp. 22–25. (in Russ.).

Ponomareva T.A., Gorbunova A.A., Ul'yanycheva K.A., Kurdyukov Ye.Ye., Taborova A.I. Vestnik Penzenskogo gosudarstvennogo universiteta, 2019, no. 4 (28), pp. 65–68. (in Russ.).

Siddique A.B., Rahman S.M.M., Hossain M.A. Arabian Journal of Chemistry, 2016, vol. 9, pp. S1185–S1189. DOI: 10.1016/j.arabjc.2012.01.004.

Berzegova A.A. Novyye tekhnologii, 2007, no. 4, pp. 40–42. (in Russ.).

Subbotina M.A. Tekhnika i tekhnologiya pishchevykh proizvodstv, 2009, no. 4(15), pp. 54–57. (in Russ.).

Atteh J., Onagbesan O., Tona K., Buyse J., Decuypere E., Geuns J. Archivos de zootecnia, 2011, vol. 60(229), pp. 133–136.

Talipova M., Glushenkova A.I. Chemistry of natural compounds, 1998, vol. 34(2), pp. 134–136.

Sholichin M., Yamasaki K., Kasai R., Tanaka O. Chemical and Pharmaceutical Bulletin, 1980, vol. 28(3), pp. 1006–1008. DOI: 10.1248/cpb.28.1006.

Nabeta K., Kasai T., Sugisawa H. Agricultural and Biological Chemistry, 1976, vol. 40(10), pp. 2103–2104. DOI: 10.1080/00021369.1976.10862360.

Fujita S., Taka K., Fujita Y. Yakugaku Zasshi, 1977, vol. 97, pp. 692–694.

D’Agostino M., DeSimone F., Pizza C. Boll. Soc. Ital. Biol. Sper., 1984, vol. 60(12), pp. 2237–2240.

Kakhkhorova S.I.K., Karomatov I.D. Biologiya i integrativnaya meditsina, 2017, no. 11, pp. 107–125. (in Russ.).

Cho B.O., Ryu H.W., So Y., Cho J.K., Woo H.S., Jin C.H., Seo K.I., Park J.C., Jeong I.Y. Food Chem. Toxicol., 2013, vol. 62, pp. 638–644. DOI: 10.1016/j.fct.2013.09.011.

Igamberdiyeva P.K., Osinskaya N.S. Khimiya rastitel'nogo syr'ya, 2010, no. 4, pp. 121–124. (in Russ.).

Kochetov A.A. Izucheniye osobennostey rosta i razvitiya rasteniy stevii (Stevia rebaudiana Bertoni) v reguli-ruyemykh usloviyakh: avtoref. diss. … kand. biol. nauk. [Study of the peculiarities of growth and development of stevia plants (Stevia rebaudiana Bertoni) under regulated conditions: abstract diss. ... Cand. biol. sciences]. St.-Petersburg, 1996, 22 p. (in Russ.).

Komissarenko N.F. Rastitel'nyye resursy, 1994, no. 1, pp. 53–64. (in Russ.).

Podporinova G.K., Verzilina N.D., Rudakova L.V., Polyanskaya N.K., Yashin Ya.I. Pishchevaya promyshlennost', 2005, no. 9, p. 97. (in Russ.).

Demina N.V., Kochetov A.A., Shevchenko Ya.A., Smetanskaya I.N., Kanarskiy A.V., Kanarskaya Z.A. Vestnik Kazanskogo tekhnologicheskogo universiteta, 2013, vol. 16, no. 23, pp. 124–126. (in Russ.).

Demina N.V., Kochetov A.A., Shevchenko Ya.A., Smetanskaya I.N., Kanarskiy A.V., Kanarskaya Z.A. Vestnik Kazanskogo tekhnologicheskogo universiteta, 2013, vol. 16, no. 20, pp. 144–147. (in Russ.).

Kochetov A.A., Kanarskiy A.V., Khuzin F.K. Novyye i netraditsionnyye rasteniya i perspektivy ikh ispol'zovaniya, 2016, no. 12, pp. 130–133. (in Russ.).

Tadhani M.B., Patel V.H., Subhash R. J. of Food Composition and Analysis, 2007, vol. 20(3-4), pp. 323–329. DOI: 10.1016/j.jfca.2006.08.004.

Ghanta S., Banerjee A., Poddar A., Chattopadhyay S. Journal of Agricultural Food Chemistry, 2007, vol. 55(26), pp. 10962–10967. DOI: 10.1021/jf071892q.

Shukla S., Mehta A., Bajpai V. Food Chem Toxicol., 2009, vol. 47, pp. 2338–2343. DOI: 10.1016/j.fct.2009.06.024.

Singh S., Garg V., Yadav D., Beg, M.N., Sharma N. International Journal of Pharmacy and Pharmaceutical Sciences, 2012, vol. 4(3), pp. 468–473.

Shukla S., Mehta A., Mehta, P., Bajpai V.K. Experimental and Toxicologic Pathology, 2012, vol. 64(7-8), pp. 807–811. DOI: 10.1016/j.fct.2009.06.024.

Zayova E., Stancheva I., Geneva M., Petrova M., Dimitrova L. Turkish Journal of Biology, 2013, vol. 37(1), pp. 106–113. DOI: 10.3906/biy-1204-64.

Shivanna N., Naika M., Khanum F., Kaul V.K. Journal of Diabetes and its Complications, 2013, vol. 27(2), pp. 103–113. DOI: 10.1016/j.jdiacomp.2012.10.001.

Ruiz J.C.R., Ordoñez Y.B.M., Basto Á.M., Campos M.R.S. Nutricion hospitalaria, 2015, vol. 31(3), pp. 1163–1170. DOI: 10.3305/nh.2015.31.3.8043.

Gawel-Beben K., Bujak T., Niziol-Lukaszewska Z. Antosiewicz B., Jakubczyk A., Karaś M., Rybczyńska K. Mole-cules, 2015, vol. 20 (4), pp. 5468–5486. DOI: 10.3390/molecules20045468.

Bender C., Graziano S., Zimmermann B.F. International Journal of Food Sciences and Nutrition, 2015, vol. 66(5), pp. 553–558. DOI: 10.3109/09637486.2015.1038223.

Periche A., Castelló M.L., Heredia A., Escriche I. Flavour and Fragrance Journal, 2016, vol. 31(2), pp. 173–177. DOI: 10.1002/ffj.3298.

Al-Mamun M., Shuvo M.M.A., Absar N. EC Nutrition, 2018, vol. 13(3), pp. 71–78.

Dyduch-Siemińska M., Najda A., Gawroński J., Balant S., Świca K., Żaba A. Molecules, 2020, vol. 25(4), p. 767. DOI: 10.3390/molecules25040767.

Kim I.-S., Yang M., Lee O.-H., Kang S.-N. LWT - Food Sci. Technol., 2011, vol. 44(5), pp. 1328−1332. DOI: 10.1016/j.lwt.2010.12.003.

Tavarini S., Angelini L.G. Journal of the Science of Food and Agriculture, 2013, vol. 93(9), pp. 2121–2129. DOI: 10.1002/jsfa.6016.

Šic Žlabur J., Voca S., Dobricevic N., Brncic M., Dujmic F., Rimac Brnčić S. International Agrophysics, 2015, vol. 29(2), pp. 231–237. DOI: 10.1515/intag-2015-0017.

Criado M.N., Barba F.J., Frígola A., Rodrigo D. Food and bioprocess technology, 2014, vol. 7(5), pp. 1518–1525. DOI: 10.1007/s11947-013-1208-3.

Mikhailov A., Nevmerzhitskaya J., Timofeeva O. Research Journal of Pharmaceutical, Biological and Chemical sci-ences, 2016, vol. 7(5), pp. 1721–1727.

Jahan I.A., Mostafa M., Hossain H., Nimmi I., Sattar A., Alim A., Moeiz S.M.I. Bangladesh Pharm. J., 2010, vol. 13(2), pp. 67–75.

Karaköse H., Jaiswal R., Kuhnert N. Journal of agricultural and food chemistry, 2011, vol. 59(18), pp. 10143–10150. DOI: 10.1021/jf202185m.

Cacciola F., Delmonte P., Jaworska K., Dugo P., Mondello L., Rader J. Journal of Chromatography A, 2011, vol. 1218(15), pp. 2012–2018. DOI: 10.1016/j.chroma.2010.08.081.

Chattopadhya D. Veena Sharma International Food Division. India, 2007.

Carakostas M.C., Curry L.L., Boileau A.C., Brusick D.J. Food and Chemical Toxicology, 2008, vol. 46(7), pp. 1–10. DOI: 10.1016/j.fct.2008.05.003.

Gibson S., Ashwell M., Arthur J., Bagley L., Lennox A., Rogers P.J., Stanner S. Perspectives in public health, 2017, vol. 137(4), pp. 237–247. DOI: 10.1177/1757913917703419.

Geuns J.M. Studies in natural products chemistry, 2002, vol. 27, pp. 299–319.

Brahmachari G., Mandal L.C., Roy R., Mondal S., Brahmachari A.K. Archiv der Pharmazie, 2011, vol. 344(1), pp. 5–19. DOI: 10.1002/ardp.201000181.

Gardana C., Scaglianti M., Simonetti P. Journal of chromatography A, 2010, vol. 1217(9), pp. 1463–1470. DOI: 10.1016/j.chroma.2009.12.036.

Jeppesen P.B., Gregersen S., Poulsen C.R., Hermansen K. Metabolism, 2000, vol. 49(2), pp. 208–214. DOI: 10.1016/S0026-0495(00)91325-8.

Jeppesen P.B., Gregersen S., Alstrup K.K., Hermansen K. Phytomedicine, 2002, vol. 9(1), pp. 9–14. DOI: 10.1078/0944-7113-00081.

Chen J., Jeppesen P.B., Abudula R., Dyrskog S.E., Colombo M., Hermansen K. Life sciences, 2006, vol. 78(15), pp. 1748–1753. DOI: 10.1016/j.lfs.2005.08.012.

Suanarunsawat T., Chaiyabutr N. Canadian journal of physiology and pharmacology, 1997, vol. 75(8), pp. 976–982. DOI: 10.1139/y00-051.

Toskulkao C., Sutheerawatananon M., Wanichanon C., Saitongdee P., Suttajit M. Journal of nutritional science and vit-aminology, 1995, vol. 41(1), pp. 105–113. DOI: 10.3177/jnsv.41.105.

Curi R., Alvarez M., Bazotte R.B., Botion L.M., Godoy J.L., Bracht A. Braz. J. Med. Biol. Res., 1986, vol. 19(6), p. 771.

Atteh J., Onagbesan O., Tona K., Decuypere E., Geuns J., Buyse J. J. Anim. Physiol. Anim. Nutr., 2008, vol. 92, pp. 640–649. DOI: 10.1111/j.1439-0396.2007.00760.x.

Abudula R., Jeppesen P.B., Rolfsen S.E.D., Xiao J., Hermansen K. Metabolism, 2004, vol. 53(10), pp. 1378–1381.

Prata C., Zambonin L., Rizzo B., Maraldi T., Angeloni C., Vieceli Dalla Sega F., Fiorentini D., Hrelia S. Oxid. Med. Cell. Longev., 2017, 3724545. DOI: 10.1155/2017/3724545.

Rizzo B., Zambonin L., Angeloni C., Leoncini E., Dalla Sega F.V., Prata C., Fiorentini D., Hrelia S. Oxid. Med. Cell. Longev., 2013, 348169. DOI: 10.1155/2013/348169.

Salehi B., López M.D., Martínez-López S., Victoriano M., Sharifi-Rad J., Martorell M., Martins N. Phytotherapy Re-search, 2019, vol. 33(11), pp. 2904–2917. DOI: 10.1002/ptr.6478.

Shannon M., Rehfeld A., Frizzell C., Livingstone C., McGonagle C., Skakkebaek N.E., Wielogórska E., Connolly L. Mol. Cell. Endocrinol., 2016, vol. 427, pp. 65–72. DOI: 10.1016/j.mce. 2016.03.005.

Ritu M., Nandini J. Journal of the Science of Food and Agriculture, 2016, vol. 96(12), pp. 4231–4234. DOI: 10.1002/jsfa.7627.

Ozbayer C., Kurt H., Kalender S., Ozden H., Gunes H.V., Basaran A., Degirmenci I. J. Med. Food., 2011, vol. 14(10), pp. 1215–1222. DOI: 10.1089/jmf.2010.0280.

Philippaert K., Pironet A., Mesuere M., Sones W., Vermeiren L., Kerselaers S., Laureys J. Nature communications, 2017, vol. 8(1), pp. 1–16. DOI: 10.1038/ncomms14733.

Chan P., Tomlinson B., Chen Y.J., Liu J.C., Hsieh M.H., Cheng J.T. British journal of clinical pharmacology, 2000, vol. 50(3), pp. 215–220.

Lee C.N., Wong K.L., Liu J.C., Chen Y.J., Cheng J.T., Chan P. Planta Medica, 2001, vol. 67(09), pp. 796–799. DOI: 10.1055/s-2001-18841.

Bugaj B., Leszczyńska T., Pysz M., Kopeć A., Pacholarz J., Pysz-Izdebska K. Żywność Nauka Technologia Jakość, 2013, vol. 3(88), pp. 27–38.

Barriocanal L., Palacios M., Benitez G., Benitez S., Jimenez J.T., Jimenez N. Regul. Toxicol. Pharmacol., 2008, vol. 51, pp. 37–41. DOI: 10.1016/j.yrtph.2008.02.006.

Hsieh M.H., Chan P., Sue Y.M., Liu J.C., Liang T.H., Huang T.Y., Chen Y.J. Clinical therapeutics, 2003, vol. 25(11), pp. 2797–2808.

Liu J.C., Kao P.K., Chan P., Hsu Y.H., Hou C.C., Lien G.S., Cheng J.T. Pharmacology, 2003, vol. 67(1), pp. 14–20. DOI: 10.1159/000066782.

Ulbricht C., Isaac R., Milkin T., A Poole E., Rusie E., M Grimes Serrano J., Woods J. Cardiovascular & Hematologi-cal Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular & Hematological Agents), 2010, vol. 8(2), pp. 113–127. DOI: 10.2174/187152510791170960.

Onakpoya I.J., Heneghan C.J. European journal of preventive cardiology, 2015, vol. 22(12), pp. 1575–1587. DOI: 10.1177/2047487314560663.

Melis M.S. Journal of natural products, 1992, vol. 55(5), pp. 688–690. DOI: 10.1016/0378-8741(92)90046-T.

Jutabha P., Toskulkao C., Chatsudthipong V. Canadian journal of physiology and pharmacology, 2000, vol. 78(9), pp. 737–744. DOI: 10.1139/y00-051.

Yuajit C., Muanprasat C., Gallagher A.R., Fedeles S.V., Kittayaruksakul S., Homvisasevongsa S., Chatsudthipong V. Biochemical pharmacology, 2014, vol. 88(3), pp. 412–421. DOI: 10.1016/j.bcp.2014.01.038.

Jahangir Chughtai M.F., Pasha I., Zahoor T., Khaliq A., Ahsan S., Wu Z., Liaqat A. CyTA-Journal of Food, 2020, vol. 18(1), pp. 164–177. DOI: 10.1080/19476337.2020.1721562.

Sehar I., Kaul A., Bani S., Pal H.C., Saxena A.K. Chemico-biological interactions, 2008, vol. 173(2), pp. 115–121. DOI: 10.1016/j.cbi.2008.01.008.

Ruiz-Ruiz J.C., Moguel-Ordoñez Y.B., Segura-Campos M.R. Critical reviews in food science and nutrition, 2017, vol. 57(12), pp. 2680–2690. DOI: 10.1080/10408398.2015.1072083.

Gamboa F., Chaves M. Acta Odontológica Latinoamericana, 2012, vol. 25(2), pp. 171–175.

Gupta E., Kaushik S., Purwar S., Sharma R., Balapure A.K., Sundaram S. Pharmacogn. Mag., 2017, vol. 13(51), pp. 345–350. DOI: 10.4103/pm.pm_29_17.

Chang S.S., Cook J.M. Journal of agricultural and food chemistry, 1983, vol. 31(2), pp. 409–412.

Kroyer G. Journal für Verbraucherschutz und Lebensmittelsicherheit, 2010, vol. 5(2), pp. 225–229. DOI 10.1007/s00003-010-0557-3.

Crammer I., Ikan R. Chem. Brit., 1986, vol. 22, pp. 915–917.

Patent 147725 (US). 2009.

Patent 147727 (US). 2013.

Mogra R., Dashora V. Journal of Human Ecology, 2009, vol. 25(2), pp. 117–120.

Vershinina O.L., Asmayeva Z.I., Roslyakov Yu.F. Khlebopekarnoye proizvodstvo, 2008, no. 3, p. 50. (in Russ.).

Yesaulko N.A., Krivenko A.A., Voyskovoy A.I., Starodubtseva G.P., Zhabina V.I., Donets I.A. Vestnik APK Stavropol'ya, 2011, no. 4, pp. 7–10. (in Russ.).

Zahn S., Forker A., Krügel L., Rohm H. LWT-Food Science and Technology, 2013, vol. 50(2), pp. 695–701. DOI: 10.1016/j.lwt.2012.07.026.

Wang Y.-H., Avula B., Tang W., Wang M., Elsohly M.A., Khan I.A. Food Additives & Contaminants: Part A, 2015, vol. 32(5), pp. 674–685. DOI: 10.1080/19440049.2015.1021863.

Abdel-Salam A.M., Ammar A.S., Galal W.K. J. Food Agric. Environ., 2009, vol. 7(2), pp. 218–221.

Agarwal V., Kochhar A., Sachdeva R. Studies on Ethno-Medicine, 2009, vol. 3(2), pp. 93–98.

Agarwal V., Kochhar A., Sachdeva R. Studies on Ethno-Medicine, 2010, vol. 4(1), pp. 9–13.

Garcia-Serna E., Martinez-Saez N., Mesias M., Morales F.J., Del Castillo M.D. Polish Journal of Food and Nutrition Sciences, 2014, vol. 64(4), pp. 243–251. DOI: 10.2478/pjfns-2013-0024.

Kulthe A.A., Pawar V.D., Kotecha P.M., Chavan U.D., Bansode V.V. Journal of food science and technology, 2014, vol. 51(1), pp. 153–157. DOI: 10.1007/s13197-011-0465-2.

Manisha G., Soumya C., Indrani D. Food Hydrocolloids, 2012, vol. 29(2), pp. 363–373. DOI: 10.1016/j.foodhyd.2012.04.011.

Parpinello G.P., Versari A., Castellari M., Galassi S. Journal of Sensory Studies, 2001, vol. 16(5), pp. 471–484.

Saniah K., Samsiah, M.S. J. Trop. Agric. and Fd. Sc., 2012, vol. 40(1), pp. 23–34.

Jain P., Kachhwaha S., Kothari S.L. International Journal of Life Sciences Biotechnology and Pharma Research, 2014, vol. 3(3), pp. 15–37.

Carbonell-Capella J.M., Barba F.J., Esteve M.J., Frígola A. Innovative Food Science & Emerging Technologies, 2013, vol. 18, pp. 48–56. DOI: 10.1016/j.ifset.2013.01.011.

Dolgova A.O., Ryabtseva S.A. Sovremennaya nauka i innovatsii, 2017, no. 1(17), pp. 98–105. (in Russ.).

Lisak K., Lenc M., Jeličić I., Božanić R. Hrvatski časopis za prehrambenu tehnologiju, biotehnologiju i nutricionizam, 2012, vol. 7, pp. 39–43.

Vasil'yeva D.A., Rodina N.D., Mamayev A.V., Sergeyeva Ye.Yu. Ispol'zovaniye sovremennykh tekhnologiy v sel'skom khozyaystve i pishchevoy promyshlennosti. [Use of modern technologies in agriculture and food industry]. Per-sianovskiy, 2016, pp. 130–134. (in Russ.).

Published
2021-06-10
How to Cite
1. Kochetov A. A., Sinyavina N. G. STEVIA (STEVIA REBAUDIANA BERTONI): BIOCHEMICAL COMPOSITION, THERAPEUTIC PROPERTIES AND USE IN THE FOOD INDUSTRY (REVIEW) // chemistry of plant raw material, 2021. № 2. P. 5-27. URL: http://journal.asu.ru/cw/article/view/7931.
Section
Reviews