DEVELOPMENT OF TECHNOLOGY FOR PRODUCTION OF SUBSTANCE SILECBINE ON THE BASIS OF EC-DYSTEROIDS OF THE AERIAL PARTS OF SILENE BRAHUICA
UDC 547.672. 633.511:631.8
Abstract
The process extraction of ecdysterone from the aerial parts of Silene brahuica was studied. On the basis results research, the following extraction conditions were established: extractant – 90% ethanol, particle size of raw material – no more than 5 mm and process temperature – 20–30 °C. A five-fold extraction of ecdysterone from the aerial parts of Silene brahuica is proposed. To purify of the extract, a sequential liquid-liquid extraction is proposed, according to which the concentrated extract is diluted with water and treated three times with extraction petrol to remove hydrophobic impurities, then extracted six times with butanol to remove hydrophilic impurities. For effective drying of the silekbin substance, a filler was used, as which microcrystalline cellulose was selected in a mass ratio of 1 : 2 to the dry residue of the dried water solution. The technology of obtaining the substance of the adaptogenic and immunostimulating drug "Silekbin" from the aerial parts of Silene brahuica, which is tested on semi-industrial installations of the Pilot production of the Institute of the Chemistry of Plant Substances, has been developed.
Downloads
Metrics
References
Syrov V.N. Khimiko-farmatsevticheskiy zhurnal, 2000, vol. 34, no. 4, pp. 31–34. (in Russ.).
Isenmann E., Ambrosio G., Joseph J.F., Mazzarino M., Torre X., Zimmer P., Kazlauskas R., Goebel C., Botrè F., Diel P., Par M.K. Archives of Toxicology, 2019, vol. 93, pp. 1807–1816. DOI: 10.1007/s00204-019-02490-x.
Kutepova T.A., Syrov V.N., Khushbaktova Z.A., Saatov Z. Khimiko-farmatsevticheskiy zhurnal, 2001, vol. 35, no. 11, pp. 24−25. (in Russ.).
Kamilova A.T., Dustmukhamedova D.Kh., Khushvaktova Z.A., Syrov V.N. Pediatr, 2013, vol. 4, no. 3, pp. 47−51. (in Russ.).
Catalan R.E., Aragones M.D., Fodoy J.E., Martinez A.M. Comparative Biochemistry and Physiology Part C: Com-parative Pharmacology, 1984, vol. 78, pp. 193−195. DOI: 10.1016/0742-8413(84)90068-9.
Syrov V.N., Khushbaktova Z.A. Eksperimental'naya i klinicheskaya farmakologiya, 2001, no. 4, pp. 56−58. (in Russ.).
Hanaya R., Sasa M., Ishihara K., Akimitsu T., Iida K., Amano T., Serikawa T., Arita K., Kurisu K. Japanese Journal of Pharmacology, 1997, vol. 74, pp. 331–335. DOI: 10.1016/S0021-5198(19)31366-6.
Syrov V.N., Nabiyev A.N., Sultanov M.B. Farmakologiya i toksikologiya, 1986, no. 3, pp. 100−103. (in Russ.).
Kurmukov A.G., Yermishina O.A. Farmakologiya i toksikologiya, 1991, no. 1, pp. 27−29. (in Russ.).
Shakhmurova G.A., Mamadalieva N.Z., Zhanibekov A.A., Khushbaktova Z.A., Syrov V.N. Pharmaceutical Chemis-try Journal, 2012, vol. 46, pp. 222–224. DOI: 10.1007/s11094-012-0766-4.
Islamova Zh.I., Kaminskiy I.P., Khushbaktova Z.A., krasnov Ye.A., Osipova S.O., Syrov V.N. Infektsiya, immunitet i farmakologiya, 2013, no. 4, pp. 34–38. (in Russ.).
Kuzmenko A.I., Niki E., Noguchi N. Journal of Oleo Science, 2001, vol. 50, pp. 497−506. DOI: 10.5650/jos.50.497.
Dzhukharova M.K., Saatov, Z., Gorovits M.B., Abubakirov N.K. Chemistry of Natural Compounds, 1991, vol. 27, pp. 207–209. DOI: 10.1007/BF00629760.
Sadikov Z.T., Saatov Z. Chemistry of Natural Compounds, 1999, vol. 35, pp. 440–441. DOI: 10.1007/BF02282513.
Sadikov Z.T., Saatov Z, Girault J.P., Lafont R. Journal of Natural Products, 2000, vol. 63, pp. 987–988. DOI: 10.1021/np990609h.
Saatov Z., Gorovits M.B., Abdullaev N.D., Usmanov B., Abubakirov N.K. Chemistry of Natural Compounds, 1982, vol. 18, pp. 193–196. DOI: 10.1007/BF00577192.
Saatov Z., Gorovits M.B., Abdullaev N.D., Usmanov B., Abubakirov N.K. Chemistry of Natural Compounds, 1982, vol. 18, pp. 578–582. DOI: 10.1007/BF00575041.
Saatov Z., Abdullaev N.D., Gorovits M.B., Abubakirov N.K. Chemistry of Natural Compounds, 1984, vol. 20, pp. 700–703. DOI: 10.1007/BF00580027.
Dzhukarova M.K., Saatov Z., Abdullaev N.D. Chemistry of Natural Compounds, 1995, vol. 31, pp. 207–210. DOI: 10.1007/BF01170207.
Dzhukharova M.K., Saatov Z., Abdullaev N.D., Abubakirov N.K. Chemistry of Natural Compounds, 1994, vol. 30, pp. 680–683. DOI: 10.1007/BF00630602.
Sadykov Z.T., Saatov Z. Chemistry of Natural Compounds, 1998, vol. 34, pp. 602–604. DOI: 10.1007/BF02319284.
Dzhukharova M.K., Tashkhodzhaev B., Saatov Z., Abdullaev N.D. Chemistry of Natural Compounds, 1993, vol. 29, pp. 484–489. DOI: 10.1007/BF00630575.
Al'magambetov A.M., Temirgaziyev B.S., Zavarzin I.V., Kachala V.V., Kudabayeva P.K., Tuleuov B.I., Adekenov S.M. Khimiya rastitel'nogo syr'ya, 2016, no. 3, pp. 79–84. DOI: 10.14258/jcprm.2016031004. (in Russ.).
Tolibaev I., Mukhamedova K.S., Glushenkova A.I. Chemistry of Natural Compounds, 1993, vol. 29, pp. 444–446. DOI: 10.1007/BF00630566.
Shakhmurova G.A., Batyrbekov A.A., Egamova F.R., Khushbaktova Z.A., Syrov V.N. Immunologiya, 2013, no. 1, pp. 24–26. (in Russ.).
Dzhakhangirova M.A. Farmakologicheskoye issledovaniye summarnykh ekdisteroidsoderzhashchikh preparatov iz Si-lene brahuica, Silene viridiflora i Ajuga turkestanica v kachestve aktoprotektornykh sredstv: avtoref. dis. … kand. med. nauk. [Pharmacological study of total ecdysteroid-containing preparations from Si-lene brahuica, Silene viridiflora and Ajuga turkestanica as actoprotective agents: author. dis. ... Cand. medical sciences]. Tashkent, 2007, 25 p. (in Russ.).
Abdukadirov I.T., Yakubova M.R., Nuriddinov Kh.R., Mamatkhanov A.U., Turakhozhaev M.T. Chemistry of Natural Compounds, 2005, vol. 41, pp. 484–489. DOI: 10.1007/s10600-005-0184-x.
Copyright (c) 2021 chemistry of plant raw material
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors, which are published in this journal, agree to the following conditions:
1. Authors retain the copyright to the work and transfer to the journal the right of the first publication along with the work, at the same time licensing it under the terms of the Creative Commons Attribution License, which allows others to distribute this work with the obligatory indication of the authorship of this work and a link to the original publication in this journal .
2. The authors retain the right to enter into separate, additional contractual agreements for the non-exclusive distribution of the version of the work published by this journal (for example, to place it in the university depository or to publish it in a book), with reference to the original publication in this journal.
3. Authors are allowed to post their work on the Internet (for example, in a university repository or on their personal website) before and during the review process of this journal, as this may lead to a productive discussion, as well as more links to this published work.
