THE ANTIOXIDANT AND ELECTROCHEMICAL PROPERTIES OF THE NOVEL WATER SOLUBLE BIOFLAVONOID DERIVATIVE – DIHYDROQUERCETIN MONOSUCCINATE
Abstract
The native antioxidant dihydroquercetin has a wide spectrum of pharmacological properties, however its low solubility make cense for getting the water soluble derivatives maintaining a high antioxidant activity. A possible strategy to get this result could be a hydrophilic moiety (such as succinic acid residue) insertion into the flavonoid molecule. Being more soluble in water the novel synthetic derivative of the bioflavonoid – dihydriquercetin monosuccinate maintains a high antioxidant activity confirmed by means of TEAC method and the voltammetry data. Dihydriquercetin monosuccinate redox transformations on a graphite electrode proving the high antioxidant activity of the studied compound, at the same time demonstrate a complex character. Better understanding of this character is a possible way to the dihydriquercetin monosuccinate redox parameters control under different conditions and/or in the different environments.
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Internet-версия Государственного реестра лекарственных средств. URL: http://www.drugreg.ru/Bases/WebReestrQuery.asp (дата обращения 03.05.2012).
Плотников М.Б., Тюкавкина Н.А., Плотникова Т.М. Лекарственные препараты на основе диквертина. Томск, 2005. 228 с.
Патент 2088256 (РФ). Средство для комплексной терапии заболеваний «Диквертин» и способ его получения / Н.А. Тюкавкина, В.А. Хуторянский, М.Ю. Сайботалов, Б.Н. Баженов, В.К. Колхир, И.А. Руленко, Ю.А. Ко-лесник. 1997.
Patent 2167414A (UK). Silibinin derivatives / R. Braatz, K. Gorler, G. Halbach, H. Soicke, K. Schmidt. 1986.
Janeiro P., Conduneanu O., Brett A.M.O. Chrysin and (±) – Taxifolin electrochemical oxidation mechanisms // Electroanalysis. 2005. Vol. 17, N12. Pp. 1059–1064.
Saito A., Sugisawa A., Umegaki K. Comparison of photometric, electrochemical and post-column fluorescence detec-tion for the determination of flavonoids by HPLC // Shokuhin Eiseigaku Zasshi. 2001. Vol. 42, N3. Pp. 174–178.
Jørgensen L., Madsen H., Thomsen M., Dragsted L., Skibsted L. Regeneration of phenolic antioxidants from phenoxyl radicals: an ESR and electrochemical study of antioxidant hierarchy // Free Radical Researsh. 1999. Vol. 30, N3. Pp. 207–220.
Матвеев Д.А., Арбузова Е.А., Крайкивский П.Б., Апрелкова Н.Ф., Хуторянский В.А., Крюкова К.М. Электро-химическое восстановление дигидрокверцетина на ртутном электроде // Электрохимия. 2011. Т. 47, №9. С. 1096–1102.
Финкельштейн Б.Л., Даниловцева О.С., Баженов Б.Н., Сайботалов М.Ю. Синтез водорастворимых производ-ных дигидрокверцетина и янтарной кислоты и их антиоксидантная активность // Биотехнология растительно-го сырья, качество и безопасность продуктов питания: материалы докладов Всероссийской научно-практической конференции, посвященной 80-летию ИрГТУ. Иркутск, 2010. C. 79–83.
Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay // Free Radicals Biol. Med. 1999. Vol. 26. Pp. 1231–1237.
Brett C.M.A., Brett A.M.O. Electrochemistry: Principles, Methods and Applications. Oxford, 1993. Pp. 174–198.
Compton R.G., Banks C.E. Understanding Voltammetry. London, 2011. Pp. 107–152.
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