UNIFIED TECHNOLOGY FOR PRODUCTION OF A SUBSTANCE WITH ESTROGENIC ACTION FROM AERIAL PARTS OF FERULA TENUISECTA, F. KUHISTANICA, F. ANGRENII, F. TCHIMGANICA
UDC 547.672. 633.511:631.8
Abstract
The processes of selecting optimal conditions for the extraction of esters of terpenoid alcohols, purification of the extract from accompanying substances, and drying have been studied. For the extraction of esters of terpenoid alcohols from the aerial parts of F. tenuisecta, F. kuhistanica, F. angrenii, and F. tchimganica, a method of triple extraction of raw materials with 70% ethyl alcohol with forced circulation of the extractant at room temperature was chosen. To purify esters of terpenoid alcohols from lipophilic and hydrophilic substances, a purification method has been proposed that consists of condensing the extract, diluting it with water (1 : 1), five-fold treatment with extraction gasoline, followed by extraction of esters of terpenoid alcohols by five-fold extraction with ethyl acetate. To purify esters of terpenoid alcohols from accompanying substances that impart a green color, it is necessary to carry out the following processes: thickening the ethyl acetate extract to a constant weight, dissolving the thick mass with 70% ethyl alcohol and treating the alcohol solution with activated carbon in an amount of 3% of the dry weight of the extractive substances for 6 hours with constant stirring. A unified technology has been developed for the production of estrogenic substances tenestrol, kufestrol, chimfestrol, and fangestrol from the aerial parts of F. tenuisecta, F. kuhistanica, F. angrenii, F. tcimganica. The reproducibility of the developed technologies was proven with the production of substances in 5 series having the same characteristics, and stage-by-stage control was carried out. It has been established that using the developed technology, the yield of esters of terpenoid alcohols is more than 82.0% of the content in the raw material. The main losses of esters of terpenoid alcohols are observed when treating the water-vat residue with extraction gasoline.
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