CHEMICAL COMPOSITION OF WATER-STEAM DISTILLATE AND ORGANIC EXTRACTS OF RAW MEDICINAL BIRCH FUNGUS CHAGA INONOTUS OBLIQUUS (PERS.) PILAT
Abstract
Components of water-steam distillate and organic extracts of raw natural medicinal birch mushroom Chaga, Inonotus obliquus (Pers.) Pilat, are studied. Higher fatty acids C16–C18 constitute more than 90% of compounds in water-steam distillate. Hexane, chloroform and ethyl acetate extract higher fatty acids С16, С18 and tetracyclic triterpenoids. The total quantitative content of compounds in the organic extracts is inversely proportional to the polarity of the solvent. Specific tetracyclic lanostane triterpenoids (inotodiol, trametenolic acid and 3β-hydroxylanosta-8,24-dien-21-al) constitute 50-60% of compounds in organic extracts. The inotodiol is prevailing component of organic extracts. It was reported to exhibit in vitro powerful antitumor activity. Further study of biological activity is needed. Therefore, the extraction of Chaga with organic solvent is useful for experimental and clinical pharmacological studies of specific tetracyclic lanostane triterpenoids (inotodiol, trametenolic acid and 3β-hydroxylanosta-8,24-dien-21-al).
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